Curing Genetic Diseases through Genome Reprogramming (Volume 182) (Progress in Molecular Biology and Translational Science, Volume 182) - Hardcover

Hardcover

ISBN 10: 0323853013 ISBN 13: 9780323853019

Publisher: Academic Press, 2021

Synopsis

Curing Genetic Diseases through Genome Reprogramming, Volume 182 captures an historic moment in the field of gene therapy―the dawn of a new age in which the dream of curing genetic diseases has become realizable. The volume presents the most clinically advanced gene therapy and genome editing approaches for the treatment of genetic diseases in specific organs, including difficult therapeutic targets, futuristic ideas of genetic interventions, and large scale human genome repair. An initial chapter addresses the complex ethical aspects involved in the very idea of modifying the human genome.

• Provides a comprehensive view of gene therapy and genome editing technologies, including epigenetic editing
• Describes the state-of-the-art and future directions for the treatment of genetic diseases, also considering economical aspects
• Presents chapters that each give a thorough review of a specific disease, target organ or visionary approach, including ethical considerations

About this title

About the Author

Gianluca Petris is currently a Marie Skłodowska-Curie European Fellow and Investigator Scientist developing synthetic genomics tools at the Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, United Kingdom. Prior to that, as a postdoctoral fellow at the Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Italy, he developed and applied CRISPR technologies and delivery vehicles for the correction of genetic diseases. Dr. Petris published several papers in the field of CRISPR-therapeutics and CRISPR applications, filed four patent families and co-founded a company for the development of gene therapies for genetic diseases. He was awarded a MSc Degree in Medical Biotechnology working on antibody engineering and rotavirus at the University of Trieste, Italy, and a PhD in Life Sciences (Open University, United Kingdom) in recognition of his research on protein folding and protein quality control carried out at the International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.

From the Back Cover

Curing Genetic Diseases through Genome Reprogramming captures an historic moment in the field of gene therapy: the dawn of a new age in which the dream of curing genetic diseases has become realisable. The volume develops from the most clinically advanced gene therapy and genome editing approaches, for the treatment of genetic diseases in specific organs, towards the most difficult therapeutic targets and futuristic ideas of genetic interventions and large scale human genome repair. A specific initial chapter is dedicated to address the complex ethical aspects involved in the very idea of modifying the human genome.

Edition details

• Publisher: Academic Press
• Publication date: 2021
• Language: English
• ISBN 10: 0323853013
• ISBN 13: 9780323853019
• Binding: Hardcover
• Number of pages: 558