Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C (Volume 183) (Progress in Molecular Biology and Translational Science, Volume 183) - Hardcover

Hardcover

ISBN 10: 0323852998 ISBN 13: 9780323852999

Publisher: Academic Press, 2021

Synopsis

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C, Volume 183 represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this volume include discussions on the evolution of disorder, consideration of the peculiarities of phase separation of the prion protein, a general discussion of the relationships between intrinsic disorder and protein functions, coverage of the structural and functional characterization of several important intrinsically disordered proteins, such as transcription factors, outer membrane porins, trans-membrane and membrane associated proteins with ID regions, discussion of molecular simulations of IDPs, and much more.

• Provides recent studies on the intrinsically disordered proteins and their functions, along with the involvement of intrinsically disordered proteins in the pathogenesis of various diseases
• Contains numerous illustrative materials (color figures, diagrams and tables) to help readers delve into the information provided
• Includes contributions from recognized experts in the field

About this title

About the Author

Prof. Vladimir N. Uversky, PhD, DSc, FRSB, FRSC, F.A.I.M.B.E., Professor at the Department of Molecular Medicine, Morsani College of Medicine, University of South Florida (USF), is a pioneer in the field of protein intrinsic disorder. He has made a number of groundbreaking contributions in the field of protein folding, misfolding, and intrinsic disorder. He obtained his PhD from Moscow Institute of Physics and Technology and D.Sc. from the Institute of Experimental and Theoretical Biophysics, Russian Academy of Sciences. Since 2010, Professor Uversky has worked at University of South Florida, where he works on various aspects of protein intrinsic disorder phenomenon and analysis of protein folding and misfolding processes. He has authored over 1250 scientific publications and edited several books and book series on protein structure, function, folding, misfolding, and intrinsic disorder. He also servs as an editor in a number of scientific journals.

From the Back Cover

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this volume include discussion of the evolution of disorder; consideration of the peculiarities of phase separation of the prion protein; general discussion of the relationships between intrinsic disorder and protein functions; structural and functional characterization of several important intrinsically disordered proteins, such as transcription factors, outer membrane porins, trans-membrane and membrane associated proteins with ID regions; discussion of molecular simulations of IDPs, with the particular focus at ensemble generation and IDP interactions leading to disorder-to-order transitions; consideration of target-binding behavior of IDPs; discussion of the roles of flexible linkers; and consideration of the intrinsically disordered nature of the nucleosomes.

Edition details

• Publisher: Academic Press
• Publication date: 2021
• Language: English
• ISBN 10: 0323852998
• ISBN 13: 9780323852999
• Binding: Hardcover
• Number of pages: 434
• Editor: Uversky Vladimir N