Protein Delivery: Physical Systems: 10 (Pharmaceutical Biotechnology, 10) - Hardcover

Hardcover

ISBN 10: 0306453592 ISBN 13: 9780306453595

Publisher: Kluwer Academic/Plenum Publishers, 1997

Synopsis

Protein and peptide therapeutics currently represent eight of the top 100 prescription pharmaceuticals in the U.S., and biotechnology products are projected to account for 15% of the total US. prescription drug market by 2003. Of the protein and peptide products now on the market, many are administered as daily injections,though several are deliveredby noninvasive routes. For example, desmopressin is delivered as a nasal spray, and deoxyribonuclease I is administered by inhalation. Although cyclosporin A is orally active, as yet there are no general means to confer oral bioava- ability to peptides and proteins. A major advance in delivery ofpeptides was achieved with the introduction of a monthly injectable, biodegradable microsphere formulation of LHRH. Despite the enormous success of biotechnology products to date, much effort continues to be focused on the development of more convenient and noninvasive routes of administration for those products that require f- quent and prolonged dosing. Here we present an overview of the te- nologies, both developed and emerging, which are applicable to protein delivery. In addition, chapters 11 through 13 detail case studies on physical methods for delivery ofinsulin and growth hormone.

About this title

Synopsis

Thirteen chapters by industrial and academic authorities in this rapidly evolving field present detailed case histories and reviews of current sophisticated protein-drug delivery technologies. This book's highlights include a comprehensive overview of insulin delivery and a discussion of the use of biodegradable microspheres.

Edition details

• Publisher: Kluwer Academic/Plenum Publishers
• Publication date: 1997
• Language: English
• ISBN 10: 0306453592
• ISBN 13: 9780306453595
• Binding: Hardcover
• Number of pages: 454
• Editor: Sanders Lynda M., Hendren R. Wayne