Stability and Characterization of Protein and Peptide Drugs: Case Histories: 5 (Pharmaceutical Biotechnology, 5) - Hardcover

Hardcover

ISBN 10: 0306443651 ISBN 13: 9780306443657

Publisher: Springer, 1993

Synopsis

This volume attemptsto provide the formulation scientist with casehistories involving the use of therapeutic proteins and peptides that have been mar­ keted or are under clinical testing. In previous volumes of this series,funda­ mental theories and principles ofprotein characterization and stability were presented in depth by researchers in their fieldsofexpertise. The way from theory to practice isnot alwaysobvious and straightforward. There isa need for practical examples of how the principles and theories are put into use, specificallyin the development of a pharmaceutical product. It is our hope that this volume will fulfillsuch a need. Itisnot asimple task to choose a panel ofproteinsand peptides from the over 200 agents in human clinical trials. We have tried to collect a wide representation of molecules of different sizes-from 10 amino acids (Leu­ prolide) to 1020 amino acids (Muromonab CD3). The examples include agents derived from various sources including monoclonal antibodies (Mur­ omonab CD3), recombinant DNA (human and bovine growth hormones), natural source (fibrolase), and chemical synthesis (Leuprolide). Clearly this list is not intended to be encyclopedic. It isthe first time a collection of this sort has been made accessibleto the formulation scientists involved in devel­ oping protein and peptide products. Although each chapter in this volume focuses primarily on the charac­ terization and stability of a specific molecule, each has unique aspects.

About this title

Review

`A wealth of factual and illustrative material.'
Journal of Pharmacy and Pharmacology

Synopsis

For formulation scientists, presents case histories involving the use of therapeutic proteins and peptides that have been marketed or are under clinical testing. Each of the 11 chapters focuses primarily on a specific agent; examples include molecules of varying sizes, from 10 amino acids (Leuprolide) to 1,020 amino acids (Muromonab CD3), and those

Edition details

• Publisher: Springer
• Publication date: 1993
• Language: English
• ISBN 10: 0306443651
• ISBN 13: 9780306443657
• Binding: Hardcover
• Number of pages: 375
• Editor: Pearlman Rodney, Wang Y. John