Genetically Engineered Vaccines: Proceedings of a Workshop Sponsored by the National Institute of Dental Research Held in Bethesda, Maryland, November ... in Experimental Medicine and Biology) - Hardcover

Hardcover

ISBN 10: 030644349X ISBN 13: 9780306443497

Publisher: Kluwer Academic / Plenum Publishers, 1993

Synopsis

Introductory Address.- The New Biology and Vaccine Research.- Keynote Presentation.- Mucosal Immunity To Vaccines: Current Concepts for Vaccine Development and Immune Response Analysis.- Session I: Oral Diseases and Host Immune Responses.- Prospects for Human Mucosal Vaccines.- Bacterial Diseases of the Oral Tissues.- Oral Virus Infections: The Potential for Gene Transfer in Treatment and Prevention.- Session II: Update on Vaccines and Vaccine Development.- Bacterial Mucosal Vaccines.- A General Overview of Viral Vaccine Development.- Session III: Vaccines and the Mucosal Immune System.- An Update on the "Jennerian" and Modified "Jennerian" Approach to Vaccination of Infants and Young Children Against Rota Virus Diarrhea.- Induction of Mucosal and Serum Immune Responses to a Specific Antigen of Peridontal Bacteria.- IgA1 Proteases and Host-Parasite Relationships in the Oral Cavity.- Transport of Iga Immune Complexes Across Epithelial Membranes: New Concepts n Mucosal Immunity.- Effect of Mucosal Microenvironment on Immune Response to Viruses.- Session IV: Optimizing Mucosal and Systemic Immune Responses.- Induction of T Helper Cells and Cytokines For Mucosal IgA Responses.- Cytokine Production and T Cell Receptor Expression by Salivary Gland T Cell and Intraepithelial T Lymphocytes for the Regulation of the IgA Response.- Immunological Adjuvants.- Session V: Delivery Systems and Immune Analysis.- M Cell-Mediated Antigen Transport and Monoclonal IgA Antibodies For MucosalImmune Protection.- A Mechanism of Passive Immunization with Monoclonal Antibodies to a 185,000Mr Streptococcal Antigen.- Delivery of Antigens by Recombinant Avirulent Salmonella Strains.- Use of Recombinant BCG as a Vaccine Delivery Vehicle.- Vaccinia Virus Recombinants as Potential Herpes Simplex Virus Vaccines.- Liposomes and Conjugate Vaccines for Antigen Delivery and Induction of Mucosal Immune Responses.- Peroral Immunization with a Cholera Toxin-Linked Bacterial Protein Antigen and Synthetic Peptide.- Peptomers as Vaccine Candidates.- Session VI: Target Antigen Selection and Vaccine Development.- Structural and Functional Studies of Herpes Simplex Virus Glycoprotein D.- Molecular, Immunological and Functional Characterization of the Major Surfae Adhesin of Streptococcus Mutans.- Reacitve Antigens of the Periodontopathic Bacterium Actinobacillus Actinmycetemcomitans.- Immunization with Fimbrial Protein and Peptide Protects Against Porphyromonas Gingivalis- Induced Periodontal Tissue Destruction.- Vaccine Development: Progression from Target Antigen to Product.- Session VII: Immunological Correlates of Protection.- Significance of Immune Responses to Oral Antigens in Dental Diseases.- Laboratory Correlates of Protection and Protective Immunity to Bordetella Pertussis.- Future Directions.- Challenges and Opportunities in Vaccine Research.- Summary and Recommendations for Future Research.- Speakers and Moderators.- Author Index.

About this title

Synopsis

Proceedings of a National Institute of Dental Research workshop held in November, 1991, in Bethesda, Maryland. While exploring the development of vaccines in the prevention of oral diseases, the papers address three key areas: optimizing the mucosal immune response; possible antigen delivery systems; and target antigens and immunological correlates

Edition details

• Publisher: Kluwer Academic / Plenum Publishers
• Publication date: 1993
• Language: English
• ISBN 10: 030644349X
• ISBN 13: 9780306443497
• Binding: Hardcover
• Number of pages: 318
• Editor: Ciardi J.E., Etc.