Synopsis
Excerpt from The Polybasic Acids of Mesitylene
Several instances of abnormal behavior in di-ortho-substituted compounds had been recorded before this work of Meyer's, but he first pointed out the cause, and laid down the general principle that di-ortho - substitution profoundly affects the reactivity of any group. For example, A. W. Hofmann had found that he could not saponify a nitrile of isodurene.
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