Dendritic Spines - Softcover

Yuste, Rafael

Softcover

ISBN 10: 026254900X ISBN 13: 9780262549004

Publisher: MIT Press, 2023

Synopsis

A leading neurobiologist explores the fundamental function of dendritic spines in neural circuits by analyzing different aspects of their biology, including structure, development, motility, and plasticity.

Most neurons in the brain are covered by dendritic spines, small protrusions that arise from dendrites, covering them like leaves on a tree. But a hundred and twenty years after spines were first described by Ramón y Cajal, their function is still unclear. Dozens of different functions have been proposed, from Cajal's idea that they enhance neuronal interconnectivity to hypotheses that spines serve as plasticity machines, neuroprotective devices, or even digital logic elements. In Dendritic Spines, leading neurobiologist Rafael Yuste attempts to solve the "spine problem," searching for the fundamental function of spines. He does this by examining many aspects of spine biology that have fascinated him over the years, including their structure, development, motility, plasticity, biophysical properties, and calcium compartmentalization. Yuste argues that we may never understand how the brain works without understanding the specific function of spines. In this book, he offers a synthesis of the information that has been gathered on spines (much of which comes from his own studies of the mammalian cortex), linking their function with the computational logic of the neuronal circuits that use them. He argues that once viewed from the circuit perspective, all the pieces of the spine puzzle fit together nicely into a single, overarching function. Yuste connects these two topics, integrating current knowledge of spines with that of key features of the circuits in which they operate. He concludes with a speculative chapter on the computational function of spines, searching for the ultimate logic of their existence in the brain and offering a proposal that is sure to stimulate discussions and drive future research.

About this title

About the Author

Rafael Yuste is Professor in the Departments of Biological Sciences and Neuroscience at Columbia University, where he is HHMI Investigator and Codirector of the Kavli Institute for Brain Circuits.

Edition details

• Publisher: MIT Press
• Publication date: 2023
• Language: English
• ISBN 10: 026254900X
• ISBN 13: 9780262549004
• Binding: Paperback
• Number of pages: 292