Combinatorics of Genome Rearrangements (Computational Molecular Biology) - Hardcover

Guillaume Fertin; Anthony Labarre; Irena Rusu; Eric Tannier; Stéphane Vialette

Hardcover

ISBN 10: 0262062828 ISBN 13: 9780262062824

Publisher: MIT Press, 2009

Synopsis

A comprehensive survey of a rapidly expanding field of combinatorial optimization, mathematically oriented but offering biological explanations when required.

From one cell to another, from one individual to another, and from one species to another, the content of DNA molecules is often similar. The organization of these molecules, however, differs dramatically, and the mutations that affect this organization are known as genome rearrangements. Combinatorial methods are used to reconstruct putative rearrangement scenarios in order to explain the evolutionary history of a set of species, often formalizing the evolutionary events that can explain the multiple combinations of observed genomes as combinatorial optimization problems. This book offers the first comprehensive survey of this rapidly expanding application of combinatorial optimization. It can be used as a reference for experienced researchers or as an introductory text for a broader audience. Genome rearrangement problems have proved so interesting from a combinatorial point of view that the field now belongs as much to mathematics as to biology. This book takes a mathematically oriented approach, but provides biological background when necessary. It presents a series of models, beginning with the simplest (which is progressively extended by dropping restrictions), each constructing a genome rearrangement problem. The book also discusses an important generalization of the basic problem known as the median problem, surveys attempts to reconstruct the relationships between genomes with phylogenetic trees, and offers a collection of summaries and appendixes with useful additional information.

About this title

About the Authors

Guillaume Fertin is Professor of Computer Science at the University of Nantes.

Anthony Labarre received a PhD in Mathematics and Computer Science from the Université libre de Bruxelles.

Irena Rusu is Professor of Computer Science at the University of Nantes.

Eric Tannier is a Researcher at the INRIA, in the Laboratory of Biometrics and Evolutionary Biology of the University of Lyon.

Stéphane Vialette is a Researcher in the Gaspard-Monge Institute of Electronics and Computer Science at the University of Paris-Est Marne-la-Vallée.

Edition details

• Publisher: MIT Press
• Publication date: 2009
• Language: English
• ISBN 10: 0262062828
• ISBN 13: 9780262062824
• Binding: Hardcover
• Edition number: 1
• Number of pages: 312