The Autisms: Molecules to Model Systems - Hardcover

 
9780199744312: The Autisms: Molecules to Model Systems
Hardcover
ISBN 10: 0199744319 ISBN 13: 9780199744312
Publisher: OUP USA, 2012

Synopsis

This book focuses on tractable genetic finding in autism and dissects the underlying neurobiology which helps understand the pathophysiology of the disorder, ultimately leading to identifying novel treatments

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About the Author

Craig M. Powell, M.D., Ph.D. is a Neurologist and Neuroscientist interested in the molecular, cellular, and circuit-level mechanisms underlying cognitive function and cognitive dysfunction in disorders such as autism and intellectual disability. Dr. Powell has been integrally involved in understanding brain abnormalities in genetic animal models of autism based on mutations in autism-associated genes such as SHANK3, neuroligins, neurexins, and PTEN. His work integrates multiple approaches to understanding how genetic mutations lead to altered neuronal function and altered circuit function to cause the behavioral symptoms of autism. His work has identified potential therapeutic targets for autism using such models.



Lisa M. Monteggia, PhD is the Ginny and John Eulich Professor in Autism Spectrum Disorders, and Associate Professor of Psychiatry, at University of Texas Southwestern Medical Center in Dallas. Dr. Monteggia's research interests focus on the molecular and cellular basis of neural plasticity as it pertains to psychiatric disorders. She utilizes molecular, cellular, behavioral, biochemical and electrophysiological approaches to elucidate how specific genes may contribute to psychiatric disorders in animal models, specifically focusing on better understanding Rett Syndrome/Autism and depression. Once these mechanisms are understood, treatments can be developed to target specific molecular pathways for therapeutic advances.

"About this title" may belong to another edition of this title.

Publisher
OUP USA
Publication date
2012
Language
English
ISBN 10 
0199744319
ISBN 13 
9780199744312
Binding
Hardcover
Edition number
1
Number of pages
420
Editor
Powell Craig M., Monteggia Lisa M.