Glycobiology: A Practical Approach (Practical Approach Series): 125 - Softcover

Softcover

ISBN 10: 0199633711 ISBN 13: 9780199633715

Publisher: Oxford University Press, USA, 1994

Synopsis

The interest in the carbohydrates of glycoproteins has greatly intensified in the past few years. The recent development of recombinant glycoproteins for therapeutic purposes necessitates the understanding of the structure-function relationship in glycoproteins. Knowledge of the biological roles of glycoproteins has significantly expanded. For instance, it is now known that carbohydrate-protein interaction is one of the most critical events in leukocyte-endothelial cell interaction. Such developments in biology and medicine require an updated methodology that aims at the basic understanding of the structure and biosynthesis of glycoproteins. In this book, the chapters are assembled to provide basic background and methods in order to allow one to analyze the structures of glycoproteins. The subjects covered include isolation, fractionation, and structural characterization of typical glycoproteins, such as those containing N-glycans and O-glycans. The book also covers the phosphatidylinositol anchor, a new type of glycosylation to attach proteins to membranes.

About this title

Review

"Comprehensive....The subject matter is divided into eight broad sections, each of which contains multiple subdivisions under one heading. This organization permits the development of a more succinct and coherent treatment of each of the individual topics under consideration." --C. Gilbert Ashwell, National Institutes of Health, Analytical Biochemistry

Synopsis

The interest in carbohydrates of glycoproteins has greatly intensified in the past few years. The recent development of recombinant glycoproteins for therapeutic purposes necessitates the understanding of the structure-function relationship in glycoproteins has significantly expanded. For instance, it is now known that carbohydrate-protein interaction is one of the most critical events in leukocytendothelial cell interaction. Such developments in biology and medicine require an updated methodology that aims at the basic understanding of the structure and biosynthesis of glycoproteins. In this book, the chapters are assembled to provide basic background and methods in order to allow one to analyse the structures of glycoproteins. The subjects covered include isolation, fractionation and structural characterization of typical glycoproteins, such as those containing N-glycans. The book also covers the phosphatidylinositol anchor, a new type of glycosylation to attach proteins to membranes. This book is intended for graduate students and post-doctoral researchers, in both an academic and industrial setting, who are interested in the analysis of carbohydrates and glycoproteins.

Edition details

• Publisher: Oxford University Press, USA
• Publication date: 1994
• Language: English
• ISBN 10: 0199633711
• ISBN 13: 9780199633715
• Binding: Paperback
• Edition number: 1
• Number of pages: 426
• Editor: Fukuda Minoru, Kobata Akira