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Synopsis
Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.
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About the Author
Jan Vijg is Professor at the Buck Institute for Age Research in Novato, California, USA
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Aging of the Genome: The Dual Role of DNA in Life and Death
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Oxford University Press, 2007
ISBN 10: 0198569238
ISBN 13: 9780198569237
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Aging of the Genome : The Dual Role of DNA in Life and Death
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Aging of the Genome : The Dual Role of DNA in Life and Death
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ISBN 10: 0198569238
ISBN 13: 9780198569237
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Aging of the Genome: The Dual Role of DNA in Life and Death
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Paperback. Condition: new. Paperback. Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recentadvances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleteriouseffects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change. Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. This book reviews the concept of genomic instability. It provides underlying biology of aging, driven by continuing demographic change. This item is printed on demand. Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability. Seller Inventory # 9780198569237
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