The Legacy of Cell Fusion (Oxford Science Publications) - Hardcover

Hardcover

ISBN 10: 0198547722 ISBN 13: 9780198547723

Publisher: OUP Oxford, 1994

Synopsis

The powerful method of viral-induced fusion of animal cells was invented by Henry Harris and his colleagues in 1965, in order to study the genetics of somatic animal cells. This volume evaluates the impact of cell hybridization on the study of cell differentiation, gene mapping, gene regulation, and the development of monoclonal antibodies. Studies are presented on nuclear structure and function, intracellular transport, membrane protein mobility, and nuclear-cytoplasmic interactions in heterokaryons and other cells. Early experiements by Harris and co-workers suggested that gene loss plays an important role in tumour formation and that the malignant phenotype could be suppressed by hybridization with non-malignant cells. This principle has since been shown to apply to a wide range of natural and experimental tumours, in species ranging from Drosophila to man. Tumour-suppressor genes are discussed, together with the role of radiation-hybrid mapping in the analysis of genetic tumours.

The volume concludes with an article in which Henry Harris sums up some of the unsolved questions that remain to be studied in the link between cell growth and differentiation. This volume aims to celebrate the legacy of cell fusion in its proper perspective.

About this title

Review

Plan to enjoy this book. (Paul L. McNeil, College of Georgia, Trends in Cell Biology, Vol. 5, June 1995)

Synopsis

The important new technique of artificial fusion of animal cells was invented by Henry Harris and his colleagues in 1965. This volume presents some of the important subjects opened up for experimental analysis by cell hybridization. These include nuclear and cell interactions in heterokaryons, monoclonal antibody production, gene mapping and the discovery of genes able to suppress tumour formation. The book should be of interest to experimental physicians, geneticists, oncologists, cell biologists, molecular and developmental biologists and immunologists, as well as active research scientists and postgraduates.

Edition details

• Publisher: OUP Oxford
• Publication date: 1994
• Language: English
• ISBN 10: 0198547722
• ISBN 13: 9780198547723
• Binding: Hardcover
• Number of pages: 320
• Editor: Gordon Siamon