Synopsis
Chance, Development, and Aging analyses a subject that has been largely ignored until now: the sources of individual variations in development and ageing that cannot be attributed to genes or the external environment. And by doing so, this book develops new insight into ageing and the individual. Gathering and scrutinizing evidence from diverse sources, the authors examine those differences in individuals that arise during development and those that might influence outcomes of ageing. Through their research, they pose a new set of questions about the contribution of chance events during development, and although chance variations during development are well known within the sub-fields of developmental biology, there has been little recognition of their affects on variations in adult form and function. Here, the authors confront this issue with a fascinating hypothesis: chance variations in form and function, arising through development, affect individual base-line functions and individual responses to the external environment and so modify outcomes of ageing. This book will undoubtedly benefit gerontologists, geneticists, reproductive biologists, and physiologists, and it will fascinate all those interested in the outcomes of ageing.
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About the Author
Dr. Caleb E. Finch is ARCO and William Kieschnick Professor of Gerontology at the Andrus Gerontology Center, University of Southern California. Dr. Tom Kirkwood is a Professor at the University of Manchester and the Director of the Joint Center on Aging at the Universities of Manchester and Newcastle.
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Chance, Development, and Aging
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Chance, Development, and Aging
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Chance, Development, and Aging
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Chance, Development, and Aging
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Chance, Development, and Aging
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Hardcover. Condition: Fine. Leichte Rillen / Abschürfungen / Risse / Knicke; Farbtonänderung. In Chance, Development, and Aging , two leading biological gerontologists review and evaluate all of the available data to elucidate the respective roles played by genes and chance developmental events in determining the course of aging in individuals. The combination of genetic and externalenvironmental influences provides only an incomplete answer. Inbred laboratory animals, for example, exhibit a wide range of life spans despite having nearly identical genes and environments. Similarly, uncovering the genetic risks for Alzheimer's disease has not enabled doctors to predict withconfidence its onset and severity. This book argues that understanding chance events, specifically random variations during prenatal development, is essential for answering these questions. The book draws on the extensive research in developmental biology on random variations in form and function,while putting this research in a new context. The discussion sheds light on a range of questions, from understanding menopause to explaining why identical twins are not truly identical. The book will be invaluable for gerontologists, geneticists, developmental and reproductive biologists,physiologists, and a broad range of physicians and investigators in experimental medicine. Seller Inventory # 3c8bb0e3-a4e1-48bf-9fc6-5d20f9c3854c
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