The objective of this book is to review the impact of genetic variation on risk of human disease at the different major levels of organization: cells, individuals, families, and populations. The volume begins with a discussion of sources and rates of mutation which ultimately give rise to the vast amount of extant genetic variation. This is followed by presentations of current understanding of how genetic variation is maintained within and among populations. The volume ends with discussions of the implications of such variation for understanding the evolution of our species. This collection gives an unusually broad treatment of the subject, with chapters from some of the leading workers in the field. James Neel's chapter on human consanguinity effects and M. Otake's on the genetic effects of radiation associated with the dropping of the Hiroshima and Nagasaki atomic bombs should be singled out for special emphasis. As an up-to-date overview of ongoing research, this work will be of interest to a wide range of workers in the fields of human population genetics, evolution, and epidemiology.
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Most geneticists will find both useful and interesting material in this volume because of its great breadth and the quality of the authors. (William G. Hill, University of Edinburgh, Genetical Research, Volume 64 - 1994)
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Seller: N. Fagin Books, Chicago, IL, U.S.A.
Hardcover. Condition: Near Fine. 1993. Natural Histry, populatiion studies. Oxford University Press. Very good - near fine blue cloth, no dust jacket 305p. 11/24. Seller Inventory # 725137247
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Hardcover. Condition: UsedGood. Hardcover; light fading and shelf wear to exterior; boards slightly bowed; in good condition with clean text, firm binding. Seller Inventory # 95499
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1st edition. 8vo. xii + 305pp. Diagrams. Ownership inscription to title page. Original gilt lettered navy boards with red title patch to spine. ISBN 0195066251 US$7. Seller Inventory # 195588
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Hardcover. Condition: Near Fine. No Jacket. graphs & Tables (illustrator). 1st. 1st printing; black c w/gilt & red titles; 305 clean, unmarked pages/index.18 scholarly essays, including:K.M. Weiss "Medieval mappaemundi & the Conceptual Map of Genetics: Changing Views of Cancer Biology & Other Thoughts"; A. Chakravarti "Impact of Genetic, Somatic & Epigenetic Variation on Phenotype"; R.E. Ferrell "Impact of Genetic Variation in Individuals: Clonal Phenotypes Other than Cancer"; J.V. Neel "Human Consaguinity Effects Revisited: Why is the Measurable Impact of Inbeeding So Small?"; M. Otake "Genetic Risks from Exposure to the Atomic Bombs: Hiroshima & Nagasaki"; E. Boerwinkle & D.M. Hallman "Genotype-by- Environment Interaction: It's a Fact of Life"; J.W. MacCluer "Applications of Pedigree Analysis to Animal Models for Complex Diseases"; C.F.Sing & S. L. Reilly "Genetics of Common Diseases that Aggregate, but do not Segregate, in Families"; A.G. Knudson,Jr. "Pathodemes: Heredity, Environment, & Populations of Disease Susceptibility"; C.L. Hanis "Genetic Inferences from Epidemiologic Investigations"; B.R. Levin "The Maintenance of Genetic Variation in Bacterial Populations"; J.N. Spuhler "Population Genetics & Evolution n the Genus Homo in the Last Two Million Years", etc. Seller Inventory # 120532
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Einband - fest (Hardcover). Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. This monograph reviews the impact of genetic variation on the risk of human disease at the major levels of biological organization: cells, individuals, families and populations. Seller Inventory # 594390243
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