The Design and Analysis of Sequential Clinical Trials (Ellis Horwood Series in Mathematics & Its Applications) - Hardcover

Whitehead, John

Hardcover

ISBN 10: 0132025655 ISBN 13: 9780132025652

Publisher: Ellis Horwood Ltd , Publisher, 1991

Synopsis

This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results. Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries. These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses. Alternative procedures are also covered in detail, and these include –spending function methods, repeated confidence intervals and Bayesian approaches to sequential clinical trials.

About this title

Review

"...This book is clear, it provides many details and is well written..." (Statistical Methods in Medical Research, No.11, 2002)

Synopsis

This volume aims to provide a description of an important class of sequential designs for comparative clinical trials, giving consideration to the practical advantages and disadvantages of each method. The book adopts a broad approach, permitting the analysis of a variety of types of patient response. Examples given in detail include binary and ordinal responses and survival times. Emphasis is placed on the triangular test, which is a close and practical modification of the more familiar sequential probability ratio test. This 2nd edition features many real examples of clinical trial data as well as simulation results. There is a new chapter outlining the computer package PEST (Planning and Evaluating Sequential Trials).

Edition details

• Publisher: Ellis Horwood Ltd , Publisher
• Publication date: 1991
• ISBN 10: 0132025655
• ISBN 13: 9780132025652
• Binding: Hardcover
• Language: English
• Edition number: 2
• Number of pages: 300