Recent Applications of Selected Name Reactions in the Total Synthesis of Alkaloids - Softcover

Heravi, Majid M.; Zadsirjan, Vahideh

Softcover

ISBN 10: 0128240210 ISBN 13: 9780128240212

Publisher: Elsevier, 2021

Synopsis

Recent Applications of Selected Name Reactions in the Total Synthesis of Alkaloids includes comprehensive coverage of name reactions in the synthesis of alkaloids. This book highlights the synthesis of various alkaloids using special name reactions including the Diels-Alder, Friedel-Crafts, Heck, Mannich, Pauson-Khand, Pictet-Spengler, Sonogashira and Suzuki reactions.

In this book, some selected name reactions in the total synthesis of alkaloids are covered, as they can be used as the key step/steps in the synthesis of different alkaloids exhibiting various biological activities. All chapters include an introduction, history and mechanism of the name reaction, and present the origin of the natural product and its known biological activities. The pathway to total synthesis is visually illustrated, and the focus is on the step in which a name reaction is applied. Chemists working in the area of synthetic organic chemistry will find this reference useful, as well as those working to develop novel methodologies for the synthesis of natural products in both academia and industry. This book is also beneficial to biologists, pharmacists and botanists.

• Includes an introduction of alkaloids, their origins and biological properties
• Features the applications of special name reactions as the key step in the total synthesis of featured alkaloids
• Covers the pathway for the synthesis of alkaloids from commercially available or easily accessible starting materials by using at least one name reaction to achieve the desired target products

About this title

About the Authors

Majid M Heravi was born in 1952 in Mashhad, Iran. He received his B. Sc. degree from the National University of Iran in 1975 and his M. Sc. and Ph. D. degrees from Salford University, England in 1977 and 1980, respectively. He completed his doctoral thesis under the supervision of the late Jim Clarck in Salford University, England. He started his career as a research fellow in Daroupakhsh (a pharmaceutical company) in 1981 Tehran, Iran and joined as an assistant professor to Ferdowsi University of Mashhad, Iran in 1983, and was promoted to associate professor in 1993 and full professor in 1997. In 1999 he moved to Alzahra University of Tehran, Iran as professor of chemistry where he still works. He has previously been a visiting professor at UC Riverside, California, USA and Hamburg University, Hamburg, Germany. His research interests focus on heterocyclic chemistry, catalysis, organic methodology and green synthetic organic chemistry. He has published more than 850 ISI cited papers, including reviews and 12 chapters in Advances in Heterocyclic Chemistry, as well as two books with Elsevier.

Vahideh Zadsirjan received her B. Sc. in Pure Chemistry from Kharazmi University in 2002, and her M. Sc in 2007 and Ph. D degrees in organic chemistry in 2016 under the supervision of Professor Majid M. Heravi from Alzahra University Tehran, Iran. Her research is focused on heterocyclic chemistry, catalysis, organic methodology and green synthetic organic chemistry.

From the Back Cover

Recent Applications of Selected Name Reactions in the Total Synthesis of Alkaloids includes comprehensive coverage of name reactions in the synthesis of alkaloids. This book highlights the synthesis of various alkaloids using special name reactions including the Diels-Alder reaction, Friedel-Crafts reaction, Mitsunobu reaction, Stille reaction, Pictet-Spengler reaction, Suzuki reaction, Suzuki-Miyaura coupling reaction, Sharpless reaction, Ugi reaction, Sonogashira reaction and Wittig reaction. Name reactions in the total synthesis of alkaloids are covered, as they can be used as the key steps in the synthesis of different alkaloids exhibiting various biological activities. All chapters include an introduction, history and mechanism of the name reaction, and present the origin of the natural product and its known biological activities. The pathway to total synthesis is visually illustrated, and the focus is on the step in which a name reaction is applied. Chemists working in the area of synthetic organic chemistry will find this reference useful, as well as those working to develop novel methodologies for the synthesis of natural products in academia and industry.

Edition details

• Publisher: Elsevier
• Publication date: 2021
• Language: English
• ISBN 10: 0128240210
• ISBN 13: 9780128240212
• Binding: Paperback
• Edition number: 1
• Number of pages: 402