Neuro-Urology Research: A Comprehensive Overview - Softcover

Softcover

ISBN 10: 012822455X ISBN 13: 9780128224557

Publisher: Academic Press, 2023

Synopsis

**Selected for Doody’s Core Titles® 2024 in Urology**

Neuro-Urology Research: A Comprehensive Overview describes the current status of the neuro-urology field including the latest discoveries, explains in detail some of the neuroscience tools that can be used when studying the neural control of the lower urinary tract, and discusses potential future directions for research. The first section, Neuroscience in Urology Research, reviews neuro-regulators and the important anatomical brain sites. It also provides an overview of voluntary versus reflex micturition control and describes how bladder physiology readout is a useful tool in research. The second section, Fundamental and Translational Neuro-Urology Research, discusses the translational potential of basic research for patients and the impact of neuro-urology research on clinical practice. Chapters in this section provide more insight into pathologies endemic to specific patient populations and areas for treatment development opportunities. The third section, Neurobiological Tools Applied to Neuro-Urology Research, supplements the ‘A Quick Guide to the "Neuroscience Toolbox"’ and introduces research techniques such as RNA sequencing and calcium imaging of neural activity. The fourth and final section, aptly titled Research Directions and Research Opportunities, covers research directions that remain underexplored or have high therapeutic potential. Research in neuro-urology presents a route to understanding how bladder function is controlled and how urinary continence is maintained. This book provides a platform for researchers to initiate collaborations on the many underexplored research topics and to consolidate knowledge, ultimately lending itself to a coordinated and multi-center research approach that will benefit the field.

• Presents a comprehensive overview of research studies in the field of neuro-urology
• Discusses approaches to conducting neuro-urology research, including models of lower urinary tract dysfunction and methods of tracking bladder physiology
• Proposes areas of research opportunity that, if explored, could yield effective treatment options for those affected by lower urinary tract disorders
• Includes an introductory guide to useful research tools and the "Neuroscience Toolbox", as well as chapters specifically about RNA sequencing techniques and imaging bladder-associated neural circuits

About this title

About the Author

Dr. Verstegen has a broad background in research and with specific training in key areas of molecular and cellular biology, behavioral and systems neuroscience, and with expertise in stereotaxic surgery techniques, design and execution of experimental paradigms coupled with optogenetics, and mouse genetics. She graduated in Experimental and Clinical Neuroscience at Utrecht University (NL) and obtained a Ph.D. degree at the Italian Institute of Technology (IIT). Her current research projects aim to identify the neural networks that control urine storage and voiding. Because disturbances in the brain control of the bladder and sphincter can cause or contribute to LUTS, understanding these control circuits may lead to potential therapies. Besides unraveling and mapping the neural circuitry, she is interested in understanding which neuro-regulators are involved and in associating function with distinct neuron subpopulations in aspects of bladder control.

From the Back Cover

Neuro-Urology Research: A Comprehensive Overview describes the current status of the neuro-urology field, discusses potential future directions and explains the latest neuroscience tools that can be used in neuro-urology research. The first section provides an overview of the circuit-based interrogation of subcortical and spinal networks involved in bladder filling and voiding. The second section discusses the translational potential of research for patients including specific chapters on the sensation of bladder stretch, bladder pain, the effects of hormones and the potential results of neurodegeneration on bladder function. The third section compares traditional and current studies determining the need for addressing or readdressing principles or adjusting dogma. Section four introduces techniques including optogenetic manipulation and calcium imaging of neural activity, and on how these methods can be applied to neuro-urology research. The fifth and final section proposes studies in directions that have remained underexplored or otherwise controversial. Perfect for all currently researching neuro-urology, this detailed understanding of the cellular and synaptic circuits that control bladder filling and voiding and of the circuitry regulating bladder function, has the potential to inform the development of newer therapeutics for treating LUTS.

Edition details

• Publisher: Academic Press
• Publication date: 2023
• Language: English
• ISBN 10: 012822455X
• ISBN 13: 9780128224557
• Binding: Paperback
• Edition number: 1
• Number of pages: 258
• Editor: Verstegen