Intrinsically Disordered Proteins: Dynamics, Binding, and Function - Softcover

Softcover

ISBN 10: 0128163488 ISBN 13: 9780128163481

Publisher: Academic Press, 2019

Synopsis

Intrinsically Disordered Proteins: Dynamics, Binding, and Function thoroughly examines and ties together the fundamental biochemical functions of intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs), including signaling, binding, and regulation, with the methodology for study and the associated pathways for drug design and therapeutic intervention. The role of new mechanistic, computational, and experimental approaches in IDP study are explored in depth, with methods for the characterization of IDP dynamics; models, simulations, and mechanisms of IDP and IDR binding; and biological and medical implications of IDP dynamics prominently featured. Written and edited by leading scientists in the field, this book explores groundbreaking areas such as ensemble descriptions of IDPs and IDRs, single-molecule studies of IDPs and IDRs, IDPs and IDRs in membraneless organelles, and molecular mechanisms of fibrillation of IDPs.

Intrinsically Disordered Proteins provides students and researchers in biochemistry, molecular biology, and applied microbiology with a comprehensive and updated discussion of the complex dynamics of IDPs and IDRs.

About this title

About the Author

Dr. Nicola Salvi is a research scientist at the Institut de Biologie Structurale in Grenoble, France. After receiving his doctorate from the Ecole Polytechnique Fédérale de Lausanne, Switzerland, under the supervision of Geoffrey Bodenhausen, he held a postdoctoral appointment at Harvard Medical School. Dr. Salvi is an expert in characterizing protein dynamics using nuclear magnetic resonance spectroscopy. He developed hybrid approaches in which spectroscopic evidence on intrinsically disordered proteins (IDPs) is combined with molecular dynamics simulation to obtain insights into the functional dynamics of IDPs. Dr. Salvi’s studies led to identifying mechanistic paradigms of IDP motions, with important implications for our understanding of their function.

From the Back Cover

A growing body of evidence highlights the importance of intrinsically disordered proteins (IDPs) and regions (IDRs) in fundamental cellular functions and biochemical processes. Increasing evidence associates alterations in the expression levels or activity of IDPs with human pathologies; and, in recent years, researchers have placed stronger emphasis on developing computational and experimental approaches to describe binding of IDPs to their functional targets, and establish drug designs for new therapeutics acting on IDPs and IDRs.

Intrinsically Disordered Proteins: Dynamics, Binding, and Function thoroughly examines and ties together the fundamental biochemical functions of IDPs and IDRs, including signaling, binding, and regulation, with methodology for study and associated pathways for drug design and therapeutic intervention. The role of new mechanistic, computational, and experimental approaches in IDP study are explored in-depth, with methods for the characterization of IDP dynamics; models, simulations, and mechanisms of IDP and IDR binding; and biological and medical implications of IDP dynamics prominently featured.

In addition, leading researchers in the field of IDPs and IDRs contribute chapters on IDP approaches little explored to-date, such as ensemble descriptions of IDPs and IDRs, single-molecule studies of IDPs and IDRs, IDPs and IDRs in membraneless organelles, and molecular mechanisms of fibrillation of IDPs.

Edition details

• Publisher: Academic Press
• Publication date: 2019
• Language: English
• ISBN 10: 0128163488
• ISBN 13: 9780128163481
• Binding: Paperback
• Number of pages: 356
• Editor: Salvi Nicola