Virus as Populations: Composition, Complexity, Quasispecies, Dynamics, and Biological Implications - Softcover

Domingo, Esteban

Softcover

ISBN 10: 0128163313 ISBN 13: 9780128163313

Publisher: Academic Press, 2019

Synopsis

Virus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to treatment all depend on virus population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, and new antiviral strategies are included.

The book's main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere.

• Features current views on key steps in the origin of life and origins of viruses
• Includes examples relating ancestral features of viruses with their current adaptive capacity
• Explains complex phenomena in an organized and coherent fashion that is easy to comprehend and enjoyable to read
• Considers quasispecies as a framework to understand virus adaptability and disease processes

About this title

About the Author

Esteban Domingo studied chemistry and biochemistry at the University of Barcelona, Spain and spent postdoctoral stays at the University of California, Irvine and the University of Zürich. His main interests are the quasispecies structure of RNA viruses and the development of new antiviral strategies. He is presently Professor of Research of the Spanish Research Council (CSIC) at Centro de Biología Molecular "Servero Ochoa" in Madrid.

Edition details

• Publisher: Academic Press
• Publication date: 2019
• Language: English
• ISBN 10: 0128163313
• ISBN 13: 9780128163313
• Binding: Paperback
• Edition number: 2
• Number of pages: 426