Introduction to Modeling in Physiology and Medicine - Softcover

Cobelli, Claudio; Carson, Ewart

Softcover

ISBN 10: 0128157569 ISBN 13: 9780128157565

Publisher: Academic Press, 2019

Synopsis

Introduction to Modeling in Physiology and Medicine, Second Edition, develops a clear understanding of the fundamental principles of good modeling methodology. Sections show how to create valid mathematical models that are fit for a range of purposes. These models are supported by detailed explanation, extensive case studies, examples and applications. This updated edition includes clearer guidance on the mathematical prerequisites needed to achieve the maximum benefit from the material, a greater detail regarding basic approaches to modeling, and discussions on non-linear and stochastic modeling. The range of case study material has been substantially extended, with examples drawn from recent research experience.

Key examples include a cellular model of insulin secretion and its extension to the whole-body level, a model of insulin action during a meal/oral glucose tolerance test, a large-scale simulation model of type 1 diabetes and its use in in silico clinical trials and drug trials.

• Covers the underlying principles of good quantitative modeling methodology, with applied biomedical engineering and bioscience examples to ensure relevance to students, current research and clinical practice
• Includes modeling data, modeling systems, linear and non-linear systems, model identification, parametric and non-parametric models, and model validation
• Presents clear, step-by-step working plus examples and extensive case studies that relate concepts to real world applications
• Provides end-of-chapter exercises and assignments to reinforce learning

About this title

About the Authors

Claudio Cobelli received a Doctoral degree (Laurea) in Electrical Engineering in 1970 from the University of Padova, Padova, Italy. From 1970 to 1980, he was a Research Fellow of the Institute of System Science and Biomedical Engineering, National Research Council, Padova, Italy. From 1973 to 1975 and 1975 to 1981, he was Associate Professor of Biological Systems at the University of Florence and Associate Professor of Biomedical Engineering at the University of Padova, respectively. In 1981, he becomes Full Professor of Biomedical Engineering at University of Padova. From 2000 to 2009, he has been Chairman of the Graduate Program in Biomedical Engineering. From 2000 to 2011, he has been Chairman of the Ph.D. Program in Bioengineering at the University of Padova. His main research activity is in the field of modeling and identification of physiological systems, especially metabolic systems. His research is currently supported by NIH, JDRF and European Comunity. He has published 450 papers in internationally refereed journals, co-author of 8 books and holds 11 patents. He is currently Associate Editor of IEEE Transaction on Biomedical Engineering and Journal of Diabetes Science & Technology. He is on the Editorial Board of Diabetes and Diabetes Technology &Therapeutics. Dr.Cobelli has been Chairman (1999-2004) of the Italian Biomedical Engineering Group, Chairman (1990-1993 & 1993-1996) of IFAC TC on Modeling and Control of Biomedical Systems and member of the IEEE EMBS AdCom Member (2008-2009). He has been a member of the Gruppo di Esperti della Valutazione (GEV), Area 09, of the Agenzia Nazionale per la Valutazione del Sistema Universitario e della Ricerca (ANVUR) for the period 2011-2013. He is President of the Organo di Indirizzo of the Azienda Ospedaliera Universita' di Trieste In 2010 he received the Diabetes Technology Artificial Pancreas Research Award. He is Fellow of IEEE, BMES and EAMBES.

Ewart Carson is Emeritus Professor of Systems Science in the School of Mathematics, Computer Science and Engineering at City, University of London. Educated at the University of St Andrews in Scotland and City University London, he holds a PhD in Systems Science and a DSc in Measurement and Information in Medicine. He holds Honorary Membership of the Royal College of Physicians (London) , a Life Fellowship of the IEEE, Fellowships of the International Academy of Medical and Biological Engineering and the American Institute of Medical and Biological Engineers, and is a Foundation Fellow of the European Alliance for Medical and Biological Engineering and Science Publications include 13 authored and edited books and more than 300 journal papers and chapters. Areas of research interest and expertise include: modelling in physiology and medicine; modelling methodology for health resource management; clinical decision support systems; evaluation methodologies with particular application in telemedicine; and integrated policy modelling for ICT enhanced public healthcare. As a systems scientist, all this research is undertaken within a clear systemic framework.

From the Back Cover

Key Features

• Covers the underlying principles of good quantitative modeling methodology, with applied biomedical engineering and bioscience examples to ensure relevance to students, current research and clinical practice
• Key topics include: modeling data, modeling systems, linear and non-linear systems; model identification; parametric and non-parametric models; and model validation
• Clear, step-by-step working plus examples and extensive case studies relate concepts to real world applications; end of chapter exercises and assignments reinforce learning

This unified physiological modeling textbook is for students taking modeling and physiological courses in biomedical engineering and the biological and life sciences. It provides a complete introduction to the foundations, theory and practice of modeling and simulation in medicine, bioscience and engineering, and for clinical applications.

Introduction to Modeling in Physiology and Medicine, Second Edition develops a clear understanding of the fundamental principles of good modeling methodology. Readers are shown how to create valid mathematical models that are fit for a range of purposes, supported throughout by detailed explanation, extensive case studies, examples and applications.

New to this Edition:

• Clearer guidance is provided on the mathematical prerequisites needed to achieve the maximum benefit from the material to be found, particularly in the later chapters
• Greater detail regarding basic approaches to modeling is provided, particularly in the Non-linear and Stochastic Modeling sections in Chapter 5
• The range of case study material has been substantially extended, with examples drawn from recent research experience
• Key examples include: a cellular model of insulin secretion and its extension to the whole-body level; a model of insulin action during a meal/oral glucose tolerance test; a large-scale simulation model of type 1 diabetes and its use in in silico clinical trials and drug trials

About the Authors:

Claudio Cobelli, PhD, University of Padova, Italy, IEEE Life Fellow; Emeritus Professor of Biomedical Engineering; Associate Editor of IEEE Transactions on Biomedical Engineering and of Journal of Diabetes Science and Technology

Ewart Carson, DSc, City, University of London, IEEE Life Fellow; Emeritus Professor of Systems Science in the School of Mathematics, Computer Science and Engineering; Associate Editor of Computer Methods and Programs in Biomedicine

Edition details

• Publisher: Academic Press
• Publication date: 2019
• ISBN 10: 0128157569
• ISBN 13: 9780128157565
• Binding: Paperback
• Language: English
• Edition number: 2
• Number of pages: 384