DNA Repair: Volume 115 (Advances in Protein Chemistry and Structural Biology, Volume 115) - Hardcover

Hardcover

ISBN 10: 0128155590 ISBN 13: 9780128155592

Publisher: Academic Press, 2019

Synopsis

DNA Repair, Volume 115, the latest release in the Advances in Protein Chemistry and Structural Biology series, provides an overview of current developments in mechanisms underlying DNA repair, their involvement in maintaining chromatin repair, the balance between chromosome breaks repair pathways, tumorigenesis, immune signaling and infection-induced inflammation. Specific chapters cover the Structure and function of the multi-subunit TFIIH with insights into nucleotide excision repair, Chromatin repair: how DNA packaging controls double-strand break repair, Controlling the balance between chromosome breaks repair pathways, The targeting of DNA repair pathways in the era of precision oncology, and much more.

• Describes advances in our understanding on DNA repair mechanisms and the involvement of their dysregulation in promoting diseases
• Presents data that is targeted to a very wide audience of specialists, researchers and students
• Contains timely chapters written by well-renowned authorities in their field
• Provides targeted information that is well supported by a number of high-quality illustrations, figures and tables

About this title

About the Author

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.

Edition details

• Publisher: Academic Press
• Publication date: 2019
• Language: English
• ISBN 10: 0128155590
• ISBN 13: 9780128155592
• Binding: Hardcover
• Number of pages: 384
• Editor: Donev