Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Volume 5: Role in Human Diseases - Hardcover

M. Hayat

Hardcover

ISBN 10: 0128010339 ISBN 13: 9780128010334

Publisher: Academic Press Inc, 2014

Synopsis

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, these books offer a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections. Considering that autophagy is associated with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases, there is a great need to understanding its role. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological situations (conditions) mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood. * Presents the most advanced information regarding the role of the autophagic system in life and death and whether autophagy acts fundamentally as a cell survivor or cell death pathway or both* Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation* States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities

About this title

About the Author

Dr. Hayat has published extensively in the fields of microscopy, cytology, immunohistochemistry, immunocytochemistry, and antigen retrieval methods. He is Distinguished Professor, Department of Biological Sciences, Kean University, Union, New Jersey, USA.

From the Back Cover

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst inciting researchers to explore their potentially important connections.

Volume 5 comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy’s effects in various cardiovascular, metabolic, and neurodegenerative disorders. In spite of the increasing importance of autophagy in the various pathophysiological conditions mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases remains poorly understood.

This book is an asset to newcomers as a concise overview of the diverse disease implications of autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge.

Key Features
• Brings together a wide swathe of experts (oncologists, neurosurgeons, physicians, research scientists, and pathologists) in the field of autophagy to discuss recent developments in this rapidly-advancing field
• Discusses the role of autophagy in cancer cell proliferation and death, and the potential of manipulation of autophagy in cancer cells as an avenue for treatment
• Covers the importance of autophagy of mitochondria to cellular homeostasis; insulin secretion by pancreatic beta cells; cardiac function; atheroschlerosis; and organ tolerance to ischemic stress
• Organized for readers into easy-to-access sections: general applications; role in cancer; and role in cardiovascular, metabolic, and neurodegenerative diseases

The editor, Dr. M. A. Hayat, is the distinguished professor at Kean University. He has published extensively in the fields of electron microscopy, tumors of the central nervous system, pediatric cancer, stem cells; cancer stem cells; epidemiology, biology, and therapy of brain metastases from primary tumors; and tumor dormancy, quiescence, and senescence.

Edition details

• Publisher: Academic Press Inc
• Publication date: 2014
• Language: English
• ISBN 10: 0128010339
• ISBN 13: 9780128010334
• Binding: Hardcover
• Number of pages: 338
• Editor: M. Hayat