Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

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9780128001097: Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

Autism Spectrum Disorders are lifelong neurodevelopmental disorders with early clinical presentation that affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite its high prevalence and insidious nature, there remains to be an extensive resource that provides information about the background and state of current research in the autism field. The first edition of Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. This volume discusses these neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms. *Introduces the genetic and non-genetic causes of autism and associated intellectual disabilities *Describes the genes implicated in ASDs and their function *Considers major individual genetic causes of autism, Rett syndrome, Fragile X syndrome, and other autism spectrum disorders, as well as their classification as synaptopathies *Thorough discussion of the clinical aspects of multiple neurodevelopmental disorders and the experimental models that exist to study their pathophysiology in vitro and in vivo, including animal models and patient-derived stem cell culture

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About the Author:

Dr. Carlo Sala is a Senior Researcher at the Institute of Neuroscience within the National Research Council of Italy at the University of Milan, and is also affiliated with the European Laboratory for Angiogenesis and Translational Research (ELAT). He has previously edited a Synaptic Plasticity volume for Springer, and is author and co-author of over sixty peer-reviewed papers published in international scientific journals in the field of neuroscience. His laboratory is interested in understanding the function of various proteins which regulate neuronal synapse formation and plasticity, and their association with ASDs and intellectual disability. Among other valuable research contributions, his research group was the first to connect synapse function to mutations in SHANK genes, which are one of the most common genetic causes of autism. Dr. Chiara Verpelli is affiliated with the Institute of Neuroscience at the National Research Council of Italy, the European Laboratory for Angiogenesis and Translational Research, and the Neurosurgery section in the Department of Neurological Sciences at the University of Milan. With interests in chemical and pharmacological technology as well, she has co-authored multiple papers in high-impact international scientific journals. Her research focus is to understand the genes involved in synapse development and function, and more recently the use of patient-specific stem cells to study neurodevelopmental diseases including ASD and intellectual disability.

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Published by Elsevier Science Publishing Co Inc, United States (2016)
ISBN 10: 0128001097 ISBN 13: 9780128001097
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Book Description Elsevier Science Publishing Co Inc, United States, 2016. Hardback. Book Condition: New. 276 x 216 mm. Language: English . Brand New Book. Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field. The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms. * Introduces the genetic and non-genetic causes of autism and associated intellectual disabilities* Describes the genes implicated in autistic spectrum disorders and their function* Considers major individual genetic causes of autism, Rett syndrome, Fragile X syndrome, and other autism spectrum disorders, as well as their classification as synaptopathies* Presents a thorough discussion of the clinical aspects of multiple neurodevelopmental disorders and the experimental models that exist to study their pathophysiology in vitro and in vivo, including animal models and patient-derived stem cell culture. Bookseller Inventory # AA59780128001097

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Published by Elsevier Science Publishing Co Inc, United States (2016)
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Book Description Elsevier Science Publishing Co Inc, United States, 2016. Hardback. Book Condition: New. 276 x 216 mm. Language: English . Brand New Book. Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field. The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms. Bookseller Inventory # AA59780128001097

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Book Description Elsevier Science Publishing Co Inc. Hardback. Book Condition: new. BRAND NEW, Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability, Carlo Sala, Chiara Verpelli, Autism Spectrum Disorders are lifelong neurodevelopmental disorders with early clinical presentation that affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite its high prevalence and insidious nature, there remains to be an extensive resource that provides information about the background and state of current research in the autism field. The first edition of Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. This volume discusses these neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms. *Introduces the genetic and non-genetic causes of autism and associated intellectual disabilities *Describes the genes implicated in ASDs and their function *Considers major individual genetic causes of autism, Rett syndrome, Fragile X syndrome, and other autism spectrum disorders, as well as their classification as synaptopathies *Thorough discussion of the clinical aspects of multiple neurodevelopmental disorders and the experimental models that exist to study their pathophysiology in vitro and in vivo, including animal models and patient-derived stem cell culture. Bookseller Inventory # B9780128001097

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Book Description Academic Press Inc, 2016. Hardcover. Book Condition: New. Brand New Book. Shipping: Once your order has been confirmed and payment received, your order will then be processed. The book will be located by our staff, packaged and despatched to you as quickly as possible. From time to time, items get mislaid en route. If your item fails to arrive, please contact us first. We will endeavour to trace the item for you and where necessary, replace or refund the item. Please do not leave negative feedback without contacting us first. All orders will be dispatched within two working days. If you have any quesions please contact us. Bookseller Inventory # V9780128001097

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Book Description Hardback. Book Condition: New. Not Signed; Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and the. book. Bookseller Inventory # ria9780128001097_rkm

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