The Genetics of Cancer: Genes Associated with Cancer Invasion, Metastasis and Cell Proliferation - Hardcover

Sherbet, Gajanan V.; Lakshmi, M. S.

Hardcover

ISBN 10: 0126398755 ISBN 13: 9780126398755

Publisher: Academic Press, 1997

Synopsis

Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology.

• Clonal evolution of the metastasis phenotype
• Cell Cycle regulation
• Apoptosis in tumour growth and metastasis
• Angiogenesis in cancer
• Cell surface glycoproteins and their receptors
• Proteinases and their inhibitors in cancer invasion
• Oncogenes and cancer metastasis
• Developmental genes
• Tumour suppressor genes
• Metastasis suppressor genes
• Dominant metastasis-associated genes

About this title

About the Authors

Dr. Gajanan V. Sherbet is Doctor of Science of London University and Fellow of the Royal College of Pathologists and the Royal Society of Chemistry. He is member of the editorial boards of many scientific and medical journals, and formerly editor of Experimental Cell Biology and Pathobiology. Dr. Sherbet’s major scientific interest is in cancer metastasis. He has focused on the role of growth factors and their signaling, and the calcium binding protein S100A4 in cell proliferation, cancer invasion and metastasis; also he is currently studying the potential of artificial neural networks for predicting breast cancer progression and prognosis. Dr. Sherbet has numerous scientific papers in international journals and has written and edited several books on cancer, such as Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy (2011) and Therapeutic Strategies in Cancer Biology and Pathology (2013), and e-books on the role of growth factors and their receptors in cancer therapy and therapeutic strategies in cancer biology and molecular pathology.

Dr. M.S. Lakshmi has held academic appointments at Johns Hopkins University in Baltimore, Harvard University, University of Bonn as Alexander von Humboldt Fellow, University of Edinburgh, Chester Beatty Research Institute in London, University of Nottingham in the Cancer Research Campaign Laboratories, and University College Medical School in London. She is presently a senior research scientist in the Cancer Research Unit at the University of Newcastle upon Tyne.

From the Back Cover

An understanding of the genetic basis of cancer and the mechanisms governing cancer invasion and its secondary spread are fundamental to our ability to design appropriate treatments.This book, written by internationally recognised experts in cancer biology, provides insights into the deregulation of the cell cycle in tumour development and integrates the function of tumour suppressor genes, oncogenes and metastasis-associated genes in the pathogenesis and progression of cancer.This volume presents an up to date and comprehensive coverage of current research in the field.@introbul:The contents include:@bul:* Clonal evolution of the metastasis phenotype* Cell Cycle regulation* Apoptosis in tumour growth and metastasis* Angiogenesis in cancer* Cell surface glycoproteins and their receptors* Proteinases and their inhibitors in cancer invasion* Oncogenes and cancer metastasis* Developmental genes* Tumour suppressor genes* Metastasis suppressor genes* Dominant metastasis-associated genes@text:This book will be of interest to all graduates, clinicians and researchers working in the fields of cancer biology, genetics and molecular biology.

Edition details

• Publisher: Academic Press
• Publication date: 1997
• Language: English
• ISBN 10: 0126398755
• ISBN 13: 9780126398755
• Binding: Hardcover
• Number of pages: 338