Extracellular Matrix and The Liver: Approach to Gene Therapy - Hardcover

Hardcover

ISBN 10: 012525251X ISBN 13: 9780125252515

Publisher: Academic Press, 2003

Synopsis

Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discusses
new strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapy
approaches.

The chapters are divided into six sections as follows:

• Basic Science of Extracellular Matrix
• Cells Responsible for Extracellular Matrix Production
• Activation Mechanism of Hepatic Cells and Signal Transduction
• Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors
• Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases
• New Strategies for the treatment of Liver Cirrhosis

• Discusses the possibility of gene therapy for liver cirrhosis
• Includes information on new aspects of hepatic stellate cells
• Written by top experts in basic science and clinical hepatology

About this title

About the Author

Edited by sao Okazaki, Yosifumi Ninomiya, Tanikawa Kyuich and ~Scott I Friedman

From the Back Cover

Extracellular Matrix and the Liver is an overview of recent progress in understanding the cellular and molecular basis of liver fibrosis, with a review of prospective targets for therapy.

Cirrhosis of the liver has been believed to be progressive and incurable. However, interferon therapy for HCV-positive chronic hepatitis and/or liver cirrhosis shows dramatic recovery in some cases. This volume addresses the new strategies for the treatment of all kinds of liver cirrhosis.

The chapters are divided into five sections:
* Basic Science of Extracellular Matrix
* Cells Responsible for Extracellular Matrix Production
* Activation Mechanism of Hepatic Stellate Cells and Signal Transduction
* Basic Science for Extracellular Matrix Metabolism Including Enzymes and Their Inhibitors
* Matrix Metalloproteinases and Tissue Inhibitors for Matrix Metalloproteinases
* New Strategies for the Treatment of Liver Cirrhosis

Edition details

• Publisher: Academic Press
• Publication date: 2003
• Language: English
• ISBN 10: 012525251X
• ISBN 13: 9780125252515
• Binding: Hardcover
• Number of pages: 512
• Editor: Okazaki Isao, Ninomiya Yosifumi, Kyuichi Tanikawa, Friedman Scott I.