The Immunoglobulins: Structure and Function - Hardcover

Nezlin, Roald

Hardcover

ISBN 10: 0125179707 ISBN 13: 9780125179706

Publisher: Academic Press, 1998

Synopsis

This book provides comprehensive up-to-date information on the structure and function of immunoglobulins. It describes the basic features of these molecules, which assists the reader in understanding how they function as an integral part of the immune system. The Immunoglobulins describes the localization and structure of different binding sites of immunoglobulin molecules, including the antigen-binding site, on the basis of latest x-ray crystallography studies. It discusses recently developed biotechnological methods that allow scientists to obtain fully active antibody molecules in vitro even without immunization and to construct new variants of immunoglobulins and their fragments by fusing with various other active molecules. A survey of recent knowledge on immunoglobulin-binding molecules other than antigens and on flexibility of immunoglobulin molecules concludes the discussion of functional aspects of the problem.

• Describes recent reviews on the structure and function of immunoglobulin molecules of various species
• Summarizes in detail recent findings on the fine structure of the antigen-combining site
• Presents comparative data on the antigen-recognizing sites of other molecules such as MHC proteins and T-cell receptors
• Summarizes growing data on immunoglobulin binding sites responsible for the reaction of immunoglobulins with molecules other than antigens
• Explores the rapid advance of recent biotechnological methods used for the construction of antibody molecules and their fragments with new properties
• Presents extensive references and is lavishly illustrated

About this title

About the Author

By Roald Nezlin

From the Back Cover

The first comprehensive review of the immunoglobulin literature in over 20 years, this book describes the basic structural features of immunoglobulin molecules, and how detailed knowledge of their structure illuminates their functional role in the immune response. A world-renowned authority on immunoglobulins, the author surveys the localization and structure of all known binding sites on immunoglobulin molecules, studies on flexibility of immunoglobulins, and the properties and significance of immunoglobulin-binding molecules other than antigens. Recently developed techniques for creating fully active antibodies, and new variant immunoglobulins, in vitro, are described in detail.

Other Highlights:

• Structure and function of immunoglobulin molecules of various species
• Fine structure of the antigen-combining site
• Comparative data on the antigen-recognizing sites of other molecules such as MHC proteins and T-cells receptors

Edition details

• Publisher: Academic Press
• Publication date: 1998
• Language: English
• ISBN 10: 0125179707
• ISBN 13: 9780125179706
• Binding: Hardcover
• Number of pages: 269