"The FactsBooks Series" has established itself as the best source of easily-accessible and accurate facts about protein groups. Described as "a growing series of excellent manuals" by "Molecular Medicine Today", and "essential works of reference" by "Trends in Biochemical Sciences", the "FactsBooks" have become the most popular comprehensive data resources available. Using an easy-to-follow format and drawing from meticulous research, the "Factsbooks" will keep you up-to-date with the latest advances in structure, amino acid sequences, physicochemical properties, and biological activity. The "Gene Knockout FactsBook" contains entries, grouped into subject disciplines, covering immunology, neurobiology, development, cancer, and other knockouts. It describes more than 600 gene knockouts described and listed in alphabetical order for easy reference. It includes entries that provide information on: general description of the protein and its function; gene symbol and database accession number; knockout construct; mouse phenotype; and key references.
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Tak W. Mak received his Ph.D. in biochemistry in 1972 from the University of Alberta after completing undergraduate and graduate studies at the University of Wisconsin. In 1997, he was appointed Professor at the University of Toronto. He is also Vice President of Research/Director of the The Campbell Family Institute for Breast Cancer Research. He has co-authored over 350 scientific papers and is a member on numerous advisory boards of scientific journals and medical centers.Mak is best recognized for the discovery of the T-cell receptor in 1984, and is a leader in the development of knockout mice for the analysis of gene function. He has also made significant contributions in the areas of virology, immunology, genetics, molecular signaling, and cancer biology. His laboratory has ongoing efforts to understand the changes in gene function that occur when cells become cancerous, cell signaling pathways, and the role of apoptosis in development and disease.
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