The revised edition of this book provides an up-to-date overview of the role of transcription factors in gene regulation, focusing primarily on the role of individual specific factors in biological processes such as the steroid response, and cell-type determination. Transcription factors play a fundamental role in turning genes on and off in particular cell types, during embryonic development, or in response to specific skills and are of interest to scientists from a variety of disciplines. However, the bewildering array of these proteins and the different ways in which they act can prove daunting to scientists and newcomers to molecular genetics. This book aims to provide the reader with a clear understanding of this field. It should be useful reading for those who seriously wish to understand the impact of molecular biology on medicine, whatever their speciality.
"synopsis" may belong to another edition of this title.
Praise for the First Edition "A standard for the genre...presented with the great clarity...profusely illustrated...admirably up-to-date." -- The Lancet
David S. Latchman graduated with a BA (First Class Honours) in Natural Sciences from Cambridge University and subsequently obtained a PhD in Genetics from Cambridge University. Following a period of post-doctoral research at Imperial College London, he was appointed to a lectureship at University College London in 1984. Subsequent appointments at UCL included Director of the Medical Molecular Biology Unit (1988), Professor of Molecular Pathology and Head of the Department of Molecular Pathology (1991), Director of the Windeyer Institute of Medical Sciences (1996) and in 1999, Dean of the Institute of Child Health and Professor of Human Genetics. At the beginning of 2003, he took up a new appointment as Master of Birkbeck, University of London, leading this multi-faculty College comprising over 1,000 staff and 16,000 students studying at levels from short courses to PhDs. He continues to retain an active research laboratory at the Institute of Child Health, UCL and in recognition of this he is now Professor of Genetics at Birkbeck and UCL. Since he set up his own laboratory in 1984, Professor Latchman's interests have focused particularly on the regulation of gene expression in mammalian cells by specific transcription factors. Initial studies, involved the eukaryotic virus Herpes Simplex Virus (HSV) and were aimed at elucidating why this virus was able to replicate in epithelial cells, whilst establishing silent latent infections in neuronal cells. The identification of a cellular POU family transcription factor, Oct-2, which was expressed in neuronal cells and blocked the virus-lytic cycle, led to an interest in the role of specific POU family transcription factors in regulating cellular as well as viral gene expression in neuronal cells. As well as studies of the role of Oct-2, these investigations resulted in the characterisation of a small sub-family of POU family transcription factors which comprised three members: Brn-3a, Brn-3b and Brn-3c. In particular, the key role of Brn-3a in promoting neuronal differentiation and enhancing the survival of neuronal cells was defined by Professor Latchman's laboratory and has important therapeutic potential for the treatment of human neurodegenerative diseases involving losses of neuronal cells. More recently, Professor Latchman's group has also studied the role of specific transcription factors in the heart and in particular, in its response to damage caused by ischaemia, as in a heart attack. They have demonstrated that a specific transcription factor STAT-1 becomes activated during ischaemia and induces a number of genes which enhance the programmed cell death of cardiac cells, resulting in the loss of these irreplaceable cells. Thus, inhibition of STAT-1 represents a potential therapeutic mechanism for decreasing the damage caused by interruption of blood flow to the heart. On the basis of his scientific research, Professor Latchman was awarded a DSc by London University in 1994 and was appointed a Fellow of the Royal College of Pathologists (FRCPath) in 1999. He serves on a number of Committees, including the Department of Health, Genetics and Insurance Committee, the National Biological Standards Board and its Scientific Policy Advisory Committee, the Health Protection Agency and the Research Strategy Committee of the Higher Education Funding Council for England.
"About this title" may belong to another edition of this title.
£ 3.04 shipping from Germany to United Kingdom
Destination, rates & speedsFREE shipping from U.S.A. to United Kingdom
Destination, rates & speedsSeller: medimops, Berlin, Germany
Condition: good. Befriedigend/Good: Durchschnittlich erhaltenes Buch bzw. Schutzumschlag mit Gebrauchsspuren, aber vollständigen Seiten. / Describes the average WORN book or dust jacket that has all the pages present. Seller Inventory # M00124371736-G
Quantity: 1 available
Seller: Anybook.com, Lincoln, United Kingdom
Condition: Good. This is an ex-library book and may have the usual library/used-book markings inside.This book has soft covers. In good all round condition. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,650grams, ISBN:9780124371736. Seller Inventory # 5764442
Quantity: 1 available
Seller: Ammareal, Morangis, France
Softcover. Condition: Très bon. Ancien livre de bibliothèque. Edition 1995. Ammareal reverse jusqu'à 15% du prix net de cet article à des organisations caritatives. ENGLISH DESCRIPTION Book Condition: Used, Very good. Former library book. Edition 1995. Ammareal gives back up to 15% of this item's net price to charity organizations. Seller Inventory # E-984-409
Quantity: 1 available
Seller: Plurabelle Books Ltd, Cambridge, United Kingdom
Paperback. Condition: Good. 325p large format paperback, as new Language: English. Seller Inventory # 161713
Quantity: 1 available
Seller: Wonder Book, Frederick, MD, U.S.A.
Condition: Very Good. Very Good condition. 2nd edition. A copy that may have a few cosmetic defects. May also contain light spine creasing or a few markings such as an owner's name, short gifter's inscription or light stamp. Seller Inventory # X12A-04457
Quantity: 1 available
Seller: Romtrade Corp., STERLING HEIGHTS, MI, U.S.A.
Condition: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide. Seller Inventory # ABNR-123742
Quantity: 1 available
Seller: Majestic Books, Hounslow, United Kingdom
Condition: Used. pp. 304. Seller Inventory # 7422245
Quantity: 1 available
Seller: Books Puddle, New York, NY, U.S.A.
Condition: Used. pp. 304 2nd Edition. Seller Inventory # 26458490
Quantity: 1 available
Seller: Biblios, Frankfurt am main, HESSE, Germany
Condition: Used. pp. 304. Seller Inventory # 18458480
Quantity: 1 available
Seller: Mispah books, Redhill, SURRE, United Kingdom
Paperback. Condition: Like New. Like New. book. Seller Inventory # ERICA79001243717366
Quantity: 1 available