Biothermodynamics Part A: 455 (Methods in Enzymology): Volume 455 - Hardcover

Hardcover

ISBN 10: 0123745969 ISBN 13: 9780123745965

Publisher: Academic Press, 2009

Synopsis

In the past several years, there has been an explosion in the ability of biologists, molecular biologists and biochemists to collect vast amounts of data on their systems. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions. The use of thermodynamics in biological research is used as an “energy book-keeping system.” While the structure and function of a molecule is important, it is equally important to know what drives the energy force. These methods look to answer: What are the sources of energy that drive the function? Which of the pathways are of biological significance? As the base of macromolecular structures continues to expand through powerful techniques of molecular biology, such as X-ray crystal data and spectroscopy methods, the importance of tested and reliable methods for answering these questions will continue to expand as well.

About this title

Review

This volume presents robust and modern thermodynamic methods for determining the “functional energetics” of macromolecular structures with their biological functions.

Synopsis

In the last several years there has been an explosion in the ability of biologists, molecular biologists and biochemists to collect vast amounts of data on their systems. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions.

Edition details

• Publisher: Academic Press
• Publication date: 2009
• Language: English
• ISBN 10: 0123745969
• ISBN 13: 9780123745965
• Binding: Hardcover
• Number of pages: 996
• Editor: Johnson Michael L., Holt Jo M., Ackers Gary K.