Handbook of Process Chromatography: Development, Manufacturing, Validation and Economics - Hardcover

Lars Hagel

Hardcover

ISBN 10: 0123740231 ISBN 13: 9780123740236

Publisher: Academic Press, 2007

Synopsis

This book will update the original edition published in 1997. Since the publication of the first edition, the biotechnology and biologics industries have gained extensive knowledge and experience in downstream processing using chromatography and other technologies associated with recovery and purification unit operations. This book will tie that experience together for the next generation of readers.
Updates include:
- sources and productivity
- types of products made today
- experiences in clinical and licensed products
- economics
- current status of validation
- illustrations and tables
- automated column packing
- automated systems
New topics include:
- the use of disposables
- multiproduct versus dedicated production
- design principles for chromatography media and filters
- ultrafiltration principles and optimization
- risk assessments
- characterization studies
- design space
- platform technologies
- process analytical technologies (PATs)
- biogenerics
- comparability assessments

Key Features:
- new approaches to process optimiaztion
- use of patform technologies
- applying risk assessment to process design

About this title

About the Author:

Dr. Jagschies is a 30-plus year employee at GE Healthcare Life Sciences and a globally recognized expert in bioprocessing. He has published numerous papers and two books on the development, manufacturing and economics of biotherapeutics, and in 2012 he received the BioProcess International award “Thought Leader of the Decade .

About this edition

• Publisher: Academic Press
• Publication date: 2007
• ISBN 10: 0123740231
• ISBN 13: 9780123740236
• Binding: Hardcover
• Edition number: 2
• Number of pages: 400