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Synopsis
Rab GTPases now comprise a family of >63 members. They are emerging as the key hub element controlling the membrane architecture of eukaryotic cells. They are intimately involved in vesicle targeting and fusion in both the endocytic and exocytic pathways and direct the assembly and disassembly of protein complexes that include regulators (GEFs and GAPs), effectors (tethers/motors) and fusion components (SNAREs) that control membrane targeting and fusion. During the last 3 years the field has virtually exploded with the identification and characterization of many new Rab proteins and their effectors.
Our understanding of how Rab GTPases control membrane function remains at its infancy. This volume of Methods in Enzymology, GTPases Regulating Membrane Targeting and Fusion, provides a wealth of new concepts, approaches and tools to study Rab proteins in the test tube and in living cells that will be of strong benefit to both established laboratories and new investigators in the field to elucidate Rab GTPase function in cellular development, differentiation and proliferation.
- Comprehensive overview of Rab GTPase phylogeny and systems biology
- Identification and characterization of Rab GEFs, GAPs and effectors
- General methodologies to study Rab GTPase function in vitro and in vivo using biochemical, molecular and microscopy approaches
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Methods in Enzymology, Vollume 403: GTPases Regulating Membrane Targeting and Fusion
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GTPases Regulating Membrane Targeting and Fusion
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Methods in Enzymology, Vol. 403
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Methods in Enzymology, Vol. 403
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Methods In Enzymology, Vollume 403: Gtpases Regulating Membrane Targeting And Fusion
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METHODS IN ENZYMOLOGY, VOLLUME 403: GTPASES REGULATING MEMBRANE TARGETING AND FUSION
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Methods in Enzymology, Vol. 403
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GTPases Regulating Membrane Targeting and Fusion
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ISBN 13: 9780121828080
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Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Rab GTPases now comprise a family of >63 members. They are emerging as the key hub element controlling the membrane architecture of eukaryotic cells. They are intimately involved in vesicle targeting and fusion in both the endocytic and exocytic pathways and direct the assembly and disassembly of protein complexes that include regulators (GEFs and GAPs), effectors (tethers/motors) and fusion components (SNAREs) that control membrane targeting and fusion. During the last 3 years the field has virtually exploded with the identification and characterization of many new Rab proteins and their effectors. Our understanding of how Rab GTPases control membrane function remains at its infancy. This volume of Methods in Enzymology, GTPases Regulating Membrane Targeting and Fusion, provides a wealth of new concepts, approaches and tools to study Rab proteins in the test tube and in living cells that will be of strong benefit to both established laboratories and new investigators in the field to elucidate Rab GTPase function in cellular development, differentiation and proliferation. Englisch. Seller Inventory # 9780121828080
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GTPases Regulating Membrane Targeting and Fusion
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Elsevier Science & Technology, Academic Press, 2005
ISBN 10: 0121828085
ISBN 13: 9780121828080
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Buch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Rab GTPases now comprise a family of >63 members. They are emerging as the key hub element controlling the membrane architecture of eukaryotic cells. They are intimately involved in vesicle targeting and fusion in both the endocytic and exocytic pathways and direct the assembly and disassembly of protein complexes that include regulators (GEFs and GAPs), effectors (tethers/motors) and fusion components (SNAREs) that control membrane targeting and fusion. During the last 3 years the field has virtually exploded with the identification and characterization of many new Rab proteins and their effectors. Our understanding of how Rab GTPases control membrane function remains at its infancy. This volume of Methods in Enzymology, GTPases Regulating Membrane Targeting and Fusion, provides a wealth of new concepts, approaches and tools to study Rab proteins in the test tube and in living cells that will be of strong benefit to both established laboratories and new investigators in the field to elucidate Rab GTPase function in cellular development, differentiation and proliferation. Seller Inventory # 9780121828080
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METHODS IN ENZYMOLOGY: VOL-403GT PRESS REGULATING MEMBRANE TARGETING AND FUSION
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