Forensic DNA Typing: Biology, Technology, and Genetics of STR Markers

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9780121479527: Forensic DNA Typing: Biology, Technology, and Genetics of STR Markers

Since the enormously successful first edition of Forensic DNA Typing was published, the Human Genome Project has published a draft sequence of the human genome and completed the "finished reference sequence. The advent of modern DNA technology has resulted in the increased ability to perform human identity testing-desirable in a number of situations including the determination of perpetrators of violent crime such as murder and rape, resolving unestablished paternity, and identifying remains of missing persons or victims of mass disasters. The technology has been utilized in identifying remains from victims of the World Trade Center twin towers collapse following the terrorist attacks of September 11, 2001, the President Clinton-Monica Lewinsky scandal, and the identification of the remains in the Tomb of the Unknown Soldier. Indeed, our perceptions of history have been changed with DNA evidence that revealed Thomas Jefferson fathered a child by one of his slaves. This book examines the science of current forensic DNA typing methods by focusing on the biology, technology, and genetic interpretation of short tandem repeat (STR) markers, which encompass the most common forensic DNA analysis methods used today. Ten new chapters have been added to accommodate the explosion of new information since the turn of the century. *The only book available that specifically covers detailed information on mitochondrial DNA and the Y chromosome *Chapters cover the topic from introductory level right up to "cutting edge" research *High-profile cases are addressed throughout the book, near the sections dealing with the science or issues behind these cases *NEW TO THIS EDITION: D.N.A. Boxes--boxed "Data, Notes & Applications" sections throughout the book offer higher levels of detail on specific questions

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Review:

"When they write the history of forensic science for our times, Forensic DNA Typing will be cited as the classic text on the subject. John Butler's organizational and communication skills have created a book unsurpassed in its abilities to guide a reader through the principles and practices of this complex but critical subject. This book is must reading for forensic educators and their students, and requires a prominent place on the shelf of every forensic and legal practitioner. -Richard Saferstein, Ph.D., Author and Forensic Science Consultant "The much-anticipated second edition of Dr. John Butler's Forensic DNA Typing provides an enormous amount of new and valuable information about DNA typing and the issues associated with this technology. It is a 'must read' for scientists, lawyers, academics, students, police officers or anyone who wants to understand modern DNA testing and the ways in which it has transformed criminal justice systems in the United States and around the world. -Stephen Hogan, Esq., Instructor, Forensic Biology, SUNY-Albany; Faculty Member, DNA Forensics Program, American Prosecutors Research Institute ...it will be clear that the book is an exceptionally comprehensive reference, touching on every relevant aspect of current forensic DNA typing practice. Apart from coverage, the book is well edited, attractively laid out, and makes productive use of its four-color format. Abundant figures and tables help explain and enumerate basic concepts as needed. A feature that is found in several parts of the book that I found particularly appealing is the detailed sourcing of information. This is a very good book, and will serve many practitioners and students of forensic DNA typing as a single source reference. It could also serve as a text for a one semester graduate level course in forensic DNA typing and technology. It is hard to think of a topic in forensic DNA typing that is not treated in the book. Accordingly, it will be a sort of standard reference book in the area. If there are plans to keep the book up to date every few years, it has the potential to become the standard reference, perhaps something akin to Clarke in drugs and toxicology. A final point is that the book is a phenomenal bargain in this day and age at around $80 a copy. There are probably minor things about which one could quibble, but it doesn't seem productive to do so when the overall product is so good. - Journal of Forensic Sciences "Students, lecturers and laboratory workers will all welcome this new edition. At 660 pages it is double the size of the former edition and clearly contains a great deal of new material as well as having been re-arranged. Dr. Butler's book goes far beyond dealing just with high profile cases and mass disasters. He has taken the opportunity in the expanded volume to explain all aspects of DNA typing in greater detail and has produced a volume which is not only informative but high readable. It is as much a book to be enjoyed by the scientist as one to educate and inform. This is a volume which contains something of value to all forensic scientists. It does not talk down to the reader but serves as a balanced guide through the rapidly developing field of DNA studies. It is a book that should be purchased rather than borrowed or just referred to as it is an outstanding guide to the subject. - Journal of Clinical Forensic Medicine

About the Author:

John M. Butler is a NIST Fellow and Group Leader at the U.S. National Institute of Standards and Technology, Gaithersburg, Maryland. Dr. Butler earned his Ph.D. from the University of Virginia while doing DNA research in the FBI Laboratory's Forensic Science Research Unit. He has over 100 publications in this field and is a frequent presenter on the topic of DNA typing.

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