A Practical Guide to Rational Drug Design

0 avg rating
( 0 ratings by Goodreads )
 
9780081000984: A Practical Guide to Rational Drug Design

This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors' active compounds or from natural ligands of the targets; how to springboard from competitors' SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches. A Practical Guide to Rational Drug Design focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes. * Discusses various tactics applicable to daily drug design * Readers can download the materials used in the book, including structures, scripts, raw data, protocols, and codes, making this book suitable resource for short courses or workshops* Offers a unique viewpoint on drug discovery research due to the author's cross-discipline education background * Explores the author's rich experiences in both pharmaceutical and academic settings

"synopsis" may belong to another edition of this title.

About the Author:

Dr. Sun received his BSc degree in chemistry and PhD degree in physics from University of Science and Technology of China (USTC). He was awarded his second PhD degree in medicinal and computational chemistry by Clark University and UMass Med School in 1997. Dr. Sun joined the faculty of Washington University Medical School at St. Louis in 1998. One and half years later, he became a computational scientist at Roche, where he spent over ten years to support dozens of rational drug design projects in such therapeutic areas as oncology, diabetes, obesity, virology, cardiovascular disease, etc. He is a well-recognized scholar in the field of drug discovery and ADMET predictions. His QSAR model ranked the first place in the Solubility Challenge. Dr. Sun and his colleagues also delivered the most accurate model in the GPCR homology modeling contest. Dr. Sun has published over 20 first and/or corresponding author peer-reviewed research papers, including 8 invited review articles covering different aspects of drug discovery. Dr. Sun was listed as Honorable Editor of three premium journals in the field of drug discovery and chemoinformatics.

"About this title" may belong to another edition of this title.

Top Search Results from the AbeBooks Marketplace

1.

Sun Hongmao
ISBN 10: 0081000987 ISBN 13: 9780081000984
New Quantity Available: 2
Seller
Rem Distributors
(NORWALK, CT, U.S.A.)
Rating
[?]

Book Description Book Condition: New. Dust Jacket Condition: New. Shipped promptly and delivered within 3 to 5 working days. For PO BOX, APO, FPO and Puerto Rico addresses delivery done in 20 to 25 working days. Serving customers since 2006. Thousand of satisfied customers!. Bookseller Inventory # REG_9780081000984_Woodh1012_112

More Information About This Seller | Ask Bookseller a Question

Buy New
90.10
Convert Currency

Add to Basket

Shipping: 3.09
Within U.S.A.
Destination, Rates & Speeds

2.

Sun Hongmao
Published by - 2015-10-15 (2015)
ISBN 10: 0081000987 ISBN 13: 9780081000984
New Hardcover Quantity Available: 5
Seller
Chiron Media
(Wallingford, United Kingdom)
Rating
[?]

Book Description - 2015-10-15, 2015. Hardcover. Book Condition: New. Bookseller Inventory # NU-ELS-00000815

More Information About This Seller | Ask Bookseller a Question

Buy New
93.75
Convert Currency

Add to Basket

Shipping: 2.99
From United Kingdom to U.S.A.
Destination, Rates & Speeds

3.

Sun Hongmao
Published by ELSEVIER SCIENCE TECHNOLOGY, United Kingdom (2015)
ISBN 10: 0081000987 ISBN 13: 9780081000984
New Hardcover Quantity Available: 1
Seller
The Book Depository
(London, United Kingdom)
Rating
[?]

Book Description ELSEVIER SCIENCE TECHNOLOGY, United Kingdom, 2015. Hardback. Book Condition: New. 229 x 152 mm. Language: English . Brand New Book. This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors active compounds or from natural ligands of the targets; how to springboard from competitors SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches. A Practical Guide to Rational Drug Design focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes. Bookseller Inventory # AAU9780081000984

More Information About This Seller | Ask Bookseller a Question

Buy New
102.29
Convert Currency

Add to Basket

Shipping: FREE
From United Kingdom to U.S.A.
Destination, Rates & Speeds

4.

Sun Hongmao
Published by ELSEVIER SCIENCE TECHNOLOGY, United Kingdom (2015)
ISBN 10: 0081000987 ISBN 13: 9780081000984
New Hardcover Quantity Available: 1
Seller
The Book Depository US
(London, United Kingdom)
Rating
[?]

Book Description ELSEVIER SCIENCE TECHNOLOGY, United Kingdom, 2015. Hardback. Book Condition: New. 229 x 152 mm. Language: English . Brand New Book. This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors active compounds or from natural ligands of the targets; how to springboard from competitors SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches. A Practical Guide to Rational Drug Design focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes. Bookseller Inventory # AAU9780081000984

More Information About This Seller | Ask Bookseller a Question

Buy New
106.84
Convert Currency

Add to Basket

Shipping: FREE
From United Kingdom to U.S.A.
Destination, Rates & Speeds

5.

Sun Hongmao
Published by Elsevier Science & Technology 2015-10-01, Cambridge (2015)
ISBN 10: 0081000987 ISBN 13: 9780081000984
New Hardcover Quantity Available: > 20
Seller
Blackwell's
(Oxford, OX, United Kingdom)
Rating
[?]

Book Description Elsevier Science & Technology 2015-10-01, Cambridge, 2015. hardback. Book Condition: New. Bookseller Inventory # 9780081000984

More Information About This Seller | Ask Bookseller a Question

Buy New
108.51
Convert Currency

Add to Basket

Shipping: 4.50
From United Kingdom to U.S.A.
Destination, Rates & Speeds

6.

Sun Hongmao
Published by Elsevier Science & Technology
ISBN 10: 0081000987 ISBN 13: 9780081000984
New Hardcover Quantity Available: 1
Seller
THE SAINT BOOKSTORE
(Southport, United Kingdom)
Rating
[?]

Book Description Elsevier Science & Technology. Hardback. Book Condition: new. BRAND NEW, A Practical Guide to Rational Drug Design, Sun Hongmao, This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors' active compounds or from natural ligands of the targets; how to springboard from competitors' SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches. A Practical Guide to Rational Drug Design focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes. * Discusses various tactics applicable to daily drug design * Readers can download the materials used in the book, including structures, scripts, raw data, protocols, and codes, making this book suitable resource for short courses or workshops* Offers a unique viewpoint on drug discovery research due to the author's cross-discipline education background * Explores the author's rich experiences in both pharmaceutical and academic settings. Bookseller Inventory # B9780081000984

More Information About This Seller | Ask Bookseller a Question

Buy New
107.29
Convert Currency

Add to Basket

Shipping: 5.94
From United Kingdom to U.S.A.
Destination, Rates & Speeds

7.

Sun Hongmao
Published by Woodhead Publishing Ltd (2015)
ISBN 10: 0081000987 ISBN 13: 9780081000984
New Hardcover Quantity Available: 1
Seller
Ria Christie Collections
(Uxbridge, United Kingdom)
Rating
[?]

Book Description Woodhead Publishing Ltd, 2015. Book Condition: New. book. Bookseller Inventory # ria9780081000984_rkm

More Information About This Seller | Ask Bookseller a Question

Buy New
111.36
Convert Currency

Add to Basket

Shipping: 3.87
From United Kingdom to U.S.A.
Destination, Rates & Speeds

8.

Hongmao, Sun
ISBN 10: 0081000987 ISBN 13: 9780081000984
New Quantity Available: 1
Seller
Bookshub
(Karol Bagh, India)
Rating
[?]

Book Description Book Condition: New. New. US edition. Perfect condition. Ship by express service to USA, Canada, Australia, France, Italy, UK, Germany and Netherland. Customer satisfaction our priority. Bookseller Inventory # ABE-FEB-115293

More Information About This Seller | Ask Bookseller a Question

Buy New
116.70
Convert Currency

Add to Basket

Shipping: FREE
From India to U.S.A.
Destination, Rates & Speeds

9.

Sun Hongmao
ISBN 10: 0081000987 ISBN 13: 9780081000984
New Quantity Available: 1
Seller
Bookshub
(Karol Bagh, India)
Rating
[?]

Book Description Book Condition: New. New. US edition. Perfect condition. Ship by express service to USA, Canada, Australia, France, Italy, UK, Germany and Netherland. Customer satisfaction our priority. Bookseller Inventory # ABE-FEB-14377

More Information About This Seller | Ask Bookseller a Question

Buy New
116.70
Convert Currency

Add to Basket

Shipping: FREE
From India to U.S.A.
Destination, Rates & Speeds

10.

Hongmao, Sun
ISBN 10: 0081000987 ISBN 13: 9780081000984
New Quantity Available: 1
Seller
EBOOKSTORE2010
(New Delhi, ND, India)
Rating
[?]

Book Description Book Condition: Brand New. New. US edition. Customer Satisfaction guaranteed!!. Bookseller Inventory # SHUB115293

More Information About This Seller | Ask Bookseller a Question

Buy New
116.74
Convert Currency

Add to Basket

Shipping: FREE
From India to U.S.A.
Destination, Rates & Speeds

There are more copies of this book

View all search results for this book