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Published by Südwestdeutscher Verlag für Hochschulschriften, 2009
ISBN 10: 383810630XISBN 13: 9783838106304
Seller: Lucky's Textbooks, Dallas, TX, U.S.A.
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Condition: New.
Published by Südwestdeutscher Verlag für Hochschulschriften, 2009
ISBN 10: 383810630XISBN 13: 9783838106304
Seller: Ria Christie Collections, Uxbridge, United Kingdom
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Condition: New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book.
Published by Sudwestdeutscher Verlag fur Hochschulschrifte 2009-05, 2009
ISBN 10: 383810630XISBN 13: 9783838106304
Seller: Chiron Media, Wallingford, United Kingdom
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PF. Condition: New.
Published by Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Aug 2015, 2015
ISBN 10: 383810630XISBN 13: 9783838106304
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Recent findings of acrylamide in foods have sparked new interest in assessing human health hazards due to long-term exposure to this vinyl compound. Acrylamide is tumorigenic at high doses in rodents but cancer risk projections in the human population remain uncertain as the molecular pathogenesis of acrylamide at the low dietary uptake is not understood. The present work addresses the question whether transcriptional responses amplify the known genotoxicity of acrylamide. Using DNA microarrays and PCR validations, we assessed genome-wide messenger profiles induced in human cells by acrylamide and glycidamide, its more reactive metabolite. The expression changes are characterized by the up-regulation of cytoprotective factors including the GSH system and multiple antioxidants. Low-dose experiments indicate that EPHX1 represents the most sensitive biomarker for glycidamide exposure. At higher concentrations, glycidamide induces markers of tumor progression, while growth suppressors and cell adhesion molecules are down-regulated. These findings indicate that tumor-promoting transcriptional signatures may be expected only at higher doses that exceed the ordinary dietary exposure. 56 pp. Deutsch.
Published by Südwestdeutscher Verlag für Hochschulschriften, 2009
ISBN 10: 383810630XISBN 13: 9783838106304
Seller: PBShop.store US, Wood Dale, IL, U.S.A.
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PAP. Condition: New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.
Published by Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG, 2009
ISBN 10: 383810630XISBN 13: 9783838106304
Seller: AHA-BUCH GmbH, Einbeck, Germany
Book Print on Demand
Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Recent findings of acrylamide in foods have sparked new interest in assessing human health hazards due to long-term exposure to this vinyl compound. Acrylamide is tumorigenic at high doses in rodents but cancer risk projections in the human population remain uncertain as the molecular pathogenesis of acrylamide at the low dietary uptake is not understood. The present work addresses the question whether transcriptional responses amplify the known genotoxicity of acrylamide. Using DNA microarrays and PCR validations, we assessed genome-wide messenger profiles induced in human cells by acrylamide and glycidamide, its more reactive metabolite. The expression changes are characterized by the up-regulation of cytoprotective factors including the GSH system and multiple antioxidants. Low-dose experiments indicate that EPHX1 represents the most sensitive biomarker for glycidamide exposure. At higher concentrations, glycidamide induces markers of tumor progression, while growth suppressors and cell adhesion molecules are down-regulated. These findings indicate that tumor-promoting transcriptional signatures may be expected only at higher doses that exceed the ordinary dietary exposure.
Published by Südwestdeutscher Verlag für Hochschulschriften, 2009
ISBN 10: 383810630XISBN 13: 9783838106304
Seller: PBShop.store UK, Fairford, GLOS, United Kingdom
Book Print on Demand
PAP. Condition: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.
Published by Südwestdeutscher Verlag für Hochschulschriften, 2015
ISBN 10: 383810630XISBN 13: 9783838106304
Seller: moluna, Greven, Germany
Book Print on Demand
Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Recent findings of acrylamide in foods have sparked new interest in assessing human health hazards due to long-term exposure to this vinyl compound. Acrylamide is tumorigenic at high doses in rodents but cancer risk projections in the human population remai.
Published by Südwestdeutscher Verlag für Hochschulschriften, 2009
ISBN 10: 383810630XISBN 13: 9783838106304
Seller: ALLBOOKS1, Salisbury Plain, SA, Australia
Book
Published by Südwestdeutscher Verlag für Hochschulschriften, 2009
ISBN 10: 383810630XISBN 13: 9783838106304
Seller: Mispah books, Redhill, SURRE, United Kingdom
Book
Paperback. Condition: Like New. Like New. book.