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Glycidamide-induced expression signature: Transcriptional fingerprint of glycidamide, the reactive metabolite of the widespread food carcinogen acrylamide - Softcover
Recent findings of acrylamide in foods have sparked new interest in assessing human health hazards due to long-term exposure to this vinyl compound. Acrylamide is tumorigenic at high doses in rodents but cancer risk projections in the human population remain uncertain as the molecular pathogenesis of acrylamide at the low dietary uptake is not understood. The present work addresses the question whether transcriptional responses amplify the known genotoxicity of acrylamide. Using DNA microarrays and PCR validations, we assessed genome-wide messenger profiles induced in human cells by acrylamide and glycidamide, its more reactive metabolite. The expression changes are characterized by the up-regulation of cytoprotective factors including the GSH system and multiple antioxidants. Low-dose experiments indicate that EPHX1 represents the most sensitive biomarker for glycidamide exposure. At higher concentrations, glycidamide induces markers of tumor progression, while growth suppressors and cell adhesion molecules are down-regulated. These findings indicate that tumor-promoting transcriptional signatures may be expected only at higher doses that exceed the ordinary dietary exposure.
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About the Author:
Dr. med. vet. Flurina C. Clement, PhD Student;Dr. med. vet. Ramiro Dip, PhD, Principle Investigator;Prof. Dr. med. vet. Hanspeter Naegeli, Head of Toxicology Division;Institute of Veterinary Pharmacology and Toxicology, Universityof Zurich
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- PublisherSüdwestdeutscher Verlag für Hochschulschriften
- Publication date2009
- ISBN 10 383810630X
- ISBN 13 9783838106304
- BindingPaperback
- Number of pages56
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Glycidamide-induced expression signature: Transcriptional fingerprint of glycidamide, the reactive metabolite of the widespread food carcinogen acrylamide (German Edition)
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Book Description Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Recent findings of acrylamide in foods have sparked new interest in assessing human health hazards due to long-term exposure to this vinyl compound. Acrylamide is tumorigenic at high doses in rodents but cancer risk projections in the human population remain uncertain as the molecular pathogenesis of acrylamide at the low dietary uptake is not understood. The present work addresses the question whether transcriptional responses amplify the known genotoxicity of acrylamide. Using DNA microarrays and PCR validations, we assessed genome-wide messenger profiles induced in human cells by acrylamide and glycidamide, its more reactive metabolite. The expression changes are characterized by the up-regulation of cytoprotective factors including the GSH system and multiple antioxidants. Low-dose experiments indicate that EPHX1 represents the most sensitive biomarker for glycidamide exposure. At higher concentrations, glycidamide induces markers of tumor progression, while growth suppressors and cell adhesion molecules are down-regulated. These findings indicate that tumor-promoting transcriptional signatures may be expected only at higher doses that exceed the ordinary dietary exposure. 56 pp. Deutsch. Seller Inventory # 9783838106304
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Glycidamideinduced expression signature Transcriptional fingerprint of glycidamide, the reactive metabolite of the widespread food carcinogen acrylamide
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ISBN 13: 9783838106304
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Glycidamide-induced expression signature : Transcriptional fingerprint of glycidamide, the reactive metabolite of the widespread food carcinogen acrylamide
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Book Description Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Recent findings of acrylamide in foods have sparked new interest in assessing human health hazards due to long-term exposure to this vinyl compound. Acrylamide is tumorigenic at high doses in rodents but cancer risk projections in the human population remain uncertain as the molecular pathogenesis of acrylamide at the low dietary uptake is not understood. The present work addresses the question whether transcriptional responses amplify the known genotoxicity of acrylamide. Using DNA microarrays and PCR validations, we assessed genome-wide messenger profiles induced in human cells by acrylamide and glycidamide, its more reactive metabolite. The expression changes are characterized by the up-regulation of cytoprotective factors including the GSH system and multiple antioxidants. Low-dose experiments indicate that EPHX1 represents the most sensitive biomarker for glycidamide exposure. At higher concentrations, glycidamide induces markers of tumor progression, while growth suppressors and cell adhesion molecules are down-regulated. These findings indicate that tumor-promoting transcriptional signatures may be expected only at higher doses that exceed the ordinary dietary exposure. Seller Inventory # 9783838106304
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Glycidamideinduced expression signature Transcriptional fingerprint of glycidamide, the reactive metabolite of the widespread food carcinogen acrylamide
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(2009)
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ISBN 13: 9783838106304
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Book Description Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Recent findings of acrylamide in foods have sparked new interest in assessing human health hazards due to long-term exposure to this vinyl compound. Acrylamide is tumorigenic at high doses in rodents but cancer risk projections in the human population remai. Seller Inventory # 5405017
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