springer new york sep 2010 (42 results)

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Go-To Telescopes Under Suburban Skies is the first book specifically written for amateur astronomers who own, or who are about to purchase, a computer-controlled 'go-to' telescope. The advantage of the 'go-to' capability is enormous - the telescope can be aimed at any object in the sky with great speed and accuracy - which is why these instruments are so popular.Making the realistic assumption that the observer is using a relatively small telescope and is observing from a backyard in a suburban area, this book provides literally hundreds more targets beyond those offered by the built-in 'nightly tours' that feature on the telescope's computer tours. And instead of wasting many pages on maps and coordinates, it leads the computer to locate the targets, and so has room to suggest many more fascinating deep-sky objects and provide detailed observing lists and information about what's being viewed. 284 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In 1609 Galileo first used his telescope to kickstart the science of observational astronomy - an event that proved to be of enormous historic, scientific, and cultural importance. Galileo and 400 Years of Telescopic Astronomy will feature the life and achievements of Galileo, around which has pivoted the story of four centuries of telescopic astronomy. The book will detail how astronomy has progressed through four centuries and contain glimpses of future space research and astronomy goals. Uniquely, interwoven with the text will be a range of practical projects for backyard astronomers in which to participate, projects that serve to illustrate many of Galileo's scientific discoveries. The year 2009 not only marks the 400th anniversary of Galileo's initial telescopic discoveries, but it has also been chosen as the International Year of Astronomy, perfect timing for the reader to see for him or herself the way Galileo worked and thought. 312 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -An elegantly dramatized and illustrated dialog on the square root of two and the whole concept of irrational numbers. 272 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Comets have inspired wonder, excitement and even fear ever since they were first observed. But they are important members of the solar system, that contain material from early in the life of the system, held in deep-freeze. This makes them key in our understanding of the formation and evolution of many Solar System bodies.Recent ground- and space-based observations have changed much in our understanding of comets. Comets, and How to Observe Them gives a summary of our current knowledge and describes how amateur astronomers can contribute to the body of scientific knowledge of comets. This book contains many practical examples of how to construct comet light-curves, measure how fast a comet's coma expands, and determine the rotation period of the nucleus. All these examples are illustrated with drawings and photographs.Because of their unpredictable nature comets are always interesting and sometime spectacular objects to observe and image. The second part of the book therefore takes the reader through the key observing techniques that can be used with commercially available modern observing equipment, from basic observations to more scientific measurements. 268 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Choosing and Using a Refracting Telescope has been written for the many amateur astronomers who already own, or are intending to purchase, a refracting telescope - perhaps to complement their existing arsenal of larger reflecting telescopes - or for the specialist who requires a particular refractor for serious astronomical applications or nature studies.Four hundred year ago, during the winter of 1609, a relatively unknown Italian scientist, Galileo Galilei designed a spyglass with two crude lenses and turned it skyward. Since then, refractors have retained their dominance over all types of reflector in studies of the Moon, planets and double stars because of the precision of their optics and lack of a central obstruction in the optical path, which causes diffraction effects in all commercially-made reflectors.Most mature amateur astronomers got started with a 60mm refractor, or something similar. Thirty years ago, there was little choice available to the hobbyist, but in the last decade long focus crown-flint achromats have moved aside for some exquisitely crafted apochromatic designs offered by leading commercial manufacturers. There has been a huge increase in the popularity of these telescopes in the last few years, led by a significant increase in the number of companies (particularly, William Optics, Orion USA, StellarVue, SkyWatcher and AstroTech) who are now heavily marketing refractors in the amateur astronomical magazines.In Choosing and Using a Refracting Telescope, well-known observer and astronomy writer Neil English celebrates the remarkable history and evolution of the refracting telescope and looks in detail at the instruments, their development and their use. A major feature of this book is the way it compares not only different classes of refractor, but also telescopes of each class that are sold by various commercial manufacturers. The author is perhaps uniquely placed to do this, having used and testedliterally hundreds of different refracting telescopes over three decades.Because it includes many diverse subjects such as imaging with consumer-level digital cameras, imaging with webcams, and imaging with astronomical CCD cameras - that are not covered together in equal depth in any other single volume - Choosing and Using a Refracting Telescope could become the 'refractor bible' for amateur astronomers at all levels, especially those who are interested in imaging astronomical objects of every class. 296 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Statistical Physics bridges the properties of a macroscopic system and the microscopic behavior of its constituting particles, otherwise impossible due to the giant magnitude of Avogadro's number. Numerous systems of today's key technologies - such as semiconductors or lasers - are macroscopic quantum objects; only statistical physics allows for understanding their fundamentals. Therefore, this graduate text also focuses on particular applications such as the properties of electrons in solids with applications, and radiation thermodynamics and the greenhouse effect. 296 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -With a fresh geometric approach that incorporates more than 250 illustrations, this textbook sets itself apart from all others in advanced calculus. Besides the classical capstones--the change of variables formula, implicit and inverse function theorems, the integral theorems of Gauss and Stokes--the text treats other important topics in differential analysis, such as Morse's lemma and the Poincaré lemma. The ideas behind most topics can be understood with just two or three variables. The book incorporates modern computational tools to give visualization real power. Using 2D and 3D graphics, the book offers new insights into fundamental elements of the calculus of differentiable maps. The geometric theme continues with an analysis of the physical meaning of the divergence and the curl at a level of detail not found in other advanced calculus books. This is a textbook for undergraduates and graduate students in mathematics, the physical sciences, and economics. Prerequisites are an introduction to linear algebra and multivariable calculus. There is enough material for a year-long course on advanced calculus and for a variety of semester courses--including topics in geometry.The measured pace of the book, with its extensive examples and illustrations, make it especially suitable for independent study. 526 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is designed to act as an off-the-shelf guide to assist health care providers evaluating patients presenting with common musculoskeletal complaints in the primary care setting. The result of a $750,000 research grant that studied how comfortable primary care providers felt when treating musculoskeletal conditions, this book addresses the common finding that family physcians felt unprepared despite frequently seeing these types of complaints. Since the primary care physician operates in a different environment than an orthopedic surgeon, the approach to the patient presenting in the primary care clinic must also differ from the specialist's approach. This book has been divided into chapters covering major body regions and injuries, and each chapter includes: Red flags, which are conditions requiring immediate treatment and referral; basic anatomy of the body region; Clinical evaluation techniques and tear sheets for use during examination; Common clinical diagnoses; and disposition of the patient illustrated with helpful flow charts. 168 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Thisbookgrewoutof anongoing e orttomodernizeColgate University's three-term,introductory,calculus-level physicscourse. Thebookisforthe rst term of this course and is intended to help rst-year college students make a good transition from high-school physics to university physics. Thebookconcentrates onthephysicsthatexplainswhywebelievethat atoms exist and have the properties we ascribe to them. This story line, which motivates much of our professional research, has helped us limit the material presented to a more humane and more realistic amount than is presented in many beginning university physics courses. The theme of atoms also supports the presentation of more non-Newtonian topics and ideas than is customary in the rst term of calculus-level physics. We think it is important and desirable to introduce students sooner than usual to some of the major ideas that shape contemporary physicists' views of the nature and behavior of matter. Here in the second decade of the twenty- rst century such a goal seems particularly appropriate. The quantum nature of atoms and light and the mysteries associated with quantum behavior clearly interest our students. By adding and - phasizing more modern content, we seek not only to present some of the physics that engages contemporary physicists but also to attract students to take more physics. Only a few of our beginning physics students come to us sharply focused on physics or astronomy. Nearly all of them, h- ever, have taken physics in high school and found it interesting. 680 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The eld of sensory science has grown exponentially since the publication of the p- vious version of this work. Fifteen years ago the journal Food Quality and Preference was fairly new. Now it holds an eminent position as a venue for research on sensory test methods (among many other topics). Hundreds of articles relevant to sensory testing have appeared in that and in other journals such as the Journal of Sensory Studies. Knowledge of the intricate cellular processes in chemoreception, as well as their genetic basis, has undergone nothing less than a revolution, culminating in the award of the Nobel Prize to Buck and Axel in 2004 for their discovery of the olfactory receptor gene super family. Advances in statistical methodology have accelerated as well. Sensometrics meetings are now vigorous and well-attended annual events. Ideas like Thurstonian modeling were not widely embraced 15 years ago, but now seem to be part of the everyday thought process of many sensory scientists. And yet, some things stay the same. Sensory testing will always involve human participants. Humans are tough measuring instruments to work with. They come with varying degrees of acumen, training, experiences, differing genetic equipment, sensory capabilities, and of course, different preferences. Human foibles and their associated error variance will continue to place a limitation on sensory tests and actionable results. Reducing, controlling, partitioning, and explaining error variance are all at the heart of good test methods and practices. 624 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Fundamentals of Plasma Physics is a general introduction designed to present a comprehensive, logical and unified treatment of the fundamentals of plasma physics based on statistical kinetic theory, with applications to a variety of important plasma phenomena. Its clarity and completeness makes the text suitable for self-learning and for self-paced courses. Throughout the text the emphasis is on clarity, rather than formality, the various derivations are explained in detail and, wherever possible, the physical interpretations are emphasized. The mathematical treatment is set out in great detail, carrying out the steps which are usually left to the reader. The problems form an integral part of the text and most of them were designed in such a way as to provide a guideline, stating intermediate steps with answers. 704 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Biomaterials for Clinical Applications is organized according to the World Health Organization's report of the top 11 causes of death worldwide, and lays out opportunities for both biomaterials scientists and physicians to tackle each of these leading contributors to mortality. The introductory chapter discusses the global burden of disease. Each of the subsequent eleven chapters focuses on a specific disease process, beginning with the leading cause of death worldwide, cardiovascular disease. The chapters start with describing diseases where clinical needs are most pressing, and then envisions how biomaterials can be designed to address these needs, instead of the more technologically centered approached favored by most books in the field. This book, then, should appeal to chemical engineers and bioengineers who are designing new biomaterials for drug delivery and vaccine delivery, as well as tissue engineering. 296 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This impressive volume is dedicated to Mel Nathanson, a leading authoritative expert for several decades in the area of combinatorial and additive number theory. For several decades, Mel Nathanson's seminal ideas and results in combinatorial and additive number theory have influenced graduate students and researchers alike. The invited survey articles in this volume reflect the work of distinguished mathematicians in number theory, and represent a wide range of important topics in current research. This impressive volume is dedicated to Mel Nathanson, a leading authoritative expert for several decades in the area of combinatorial and additive number theory. Nathanson's numerous results have been widely published in top notch journals and in a number of excellent graduate textbooks (GTM Springer) and reference works. For several decades, Mel Nathanson's seminal ideas and results in combinatorial and additive number theory have influenced graduate students and researchers alike. The invited survey articles in this volume reflect the work of distinguished mathematicians in number theory, and represent a wide range of important topics in current research. 376 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Advances in Queueing Theory and Network Applications presents several useful mathematical analyses in queueing theory and mathematical models of key technologies in wired and wireless communication networks such as channel access controls, Internet applications, topology construction, energy saving schemes, and transmission scheduling. In sixteen high quality chapters, this work provides novel ideas, new analytical models, and simulation and experimental results by experts in the field of queueing theory and network applications.The text serves as a state-of-the-art reference for a wide range of researchers and engineers engaged in the fields of queueing theory and network applications, and can also serve as supplemental material for advanced courses in operations research, queueing theory, performance analysis, traffic theory, as well as theoretical design and management of communication networks. 332 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Random variables are rarely independent in practice and so many multivariate distributions have been proposed in the literature to give a dependence structure for two or more variables. In this book, we restrict ourselves to the bivariate distributions for two reasons: (i) correlation structure and other properties are easier to understand and the joint density plot can be displayed more easily, and (ii) a bivariate distribution can normally be extended to a multivariate one through a vector or matrix representation. This volume is a revision of Chapters 1-17 of the previous book Continuous Bivariate Distributions, Emphasising Applications authored by Drs. Paul Hutchinson and Chin-Diew Lai.The book updates the subject of copulas which have grown immensely during the past two decades. Similarly, conditionally specified distributions and skewed distributions have become important topics of discussion in this area of research. Thisvolume, which provides an up-to-date review of various developments relating to bivariate distributions in general, should be of interest to academics and graduate students, as well as applied researchers in finance, economics, science, engineering and technology.N. BALAKRISHNAN is Professor in the Department of Mathematics and Statistics at McMaster University, Hamilton, Ontario, Canada. He has published numerous research articles in many areas of probability and statistics and has authored a number of books including the four-volume series on Distributions in Statistics, jointly with Norman L. Johnson and S. Kotz, published by Wiley. He is a Fellow of the American Statistical Association and the Institute of Mathematical Statistics, and the Editor-in-Chief of Communications in Statistics and the Executive Editor of Journal of Statistical Planning and Inference.CHIN-DIEW LAI holds a Personal Chair in Statistics at Massey University, Palmerston North, New Zealand. He has published more than 100 peer-reviewed research articles and co-authored three well-received books. He was a former editor-in-chief and is now an Associate Editor of the Journal of Applied Mathematics and Decision Sciences. 724 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In the library at Trinity College, Cambridge in 1976, George Andrews of Pennsylvania State University discovered a sheaf of pages in the handwriting of Srinivasa Ramanujan. Soon designated as 'Ramanujan's Lost Notebook,' it contains considerable material on mock theta functions and undoubtedly dates from the last year of Ramanujan's life. In this book, the notebook is presented with additional material and expert commentary. 452 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The transition to adulthood involves, for most individuals, moving from school to work, establishment of long-term relationships, possibly parenting, and a number of other psychosocial transformations. Now more than ever, there is a concern within popular and research literature about children growing up too soon or too late or failing to realize changes associated with being adult. With this in mind, the book intends to answer a series of timely questions in regard to transition to adulthood and propose a wholly new approach to counseling that enables youth to engage fully in their lives and achieve their best. Active Transition to Adulthood: A New Approach for Counseling will discuss the authors' work on the transition to adulthood (including early and late adolescence) from an entirely innovative perspective - action theory. Over a period of 10-15 years the authors have collected substantial data on adolescents and youth in transition, and will present an approach to counseling based on these data and cases. The action theory perspective in which the authors have grounded their work addresses the intentional, goal-directed behavior of persons and groups that is expressed through particular actions, longer-term projects, and life-encompassing careers. In this book, both transition to adulthood and counseling will be covered in the language of goal-directed action. In this way both transition and counseling reflect and capture the action, projects, and careers in which families, youth, and clients are engaged and use to construct on-going identity and other narratives. 248 pp. Englisch.

Buch. Condition: Neu. Neuware -Cancer is a complex disease. Only 5-10% of human cancers are hereditary in nature. Many of us think of environmental agents when we think of carcinogens. The environment includes all that surrounds us, and environmental influences include not only chemical, physical and biological toxicants, but also diet and lifestyle. In this broadest sense, the environment contributes substantially in the development of human cancer. This book will describe how environment contributes to malignant transformation leading to profound changes in the genetic and signaling networks that control the functioning of the cell. It will critically discuss the understanding of the effects of environment on the development, progression and metastasis of cancer with current knowledge of the signaling networks that support functioning of transformed human cells. Genes and environmental factors that influence the origins of cancer are not necessarily the same as those that contribute to its progression and metastasis. Susceptibility gene variants for each specific cancer are being identified with emerging evidence of gene-environment interaction. Gene-environment interactions will be discussed through each specific cancer-based approach to address the question of how genetic variations can influence susceptibility to the individual type of cancer. It will also highlight and summarize epigenetic changes that increase the risk for susceptibility to a particular type of cancer, particularly in the presence of specific environmental factors. Thus, this book will contain chapters from the world's experts focused on the current evidences that support the role of environment in the cancer etiology and in the growth of malignant lesions, and discuss who may be susceptible to environmental influences. 536 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Current Ornithology publishes authoritative, up-to-date, scholarly reviews of topics selected from the full range of current research in avian biology. Topics cover the spectrum from the molecular level of organization to population biology and community ecology. The series seeks especially to review (1) fields in which an abundant recent literature will benefit from synthesis and organization, or (2) newly emerging fields that are gaining recognition as the result of recent discoveries or shifts in perspective, or (3) fields in which students of vertebrates may benefit from comparisons of birds with other classes. All chapters are invited, and authors are chosen for their leadership in the subjects under review. 204 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Challenging Cases in Allergic and Immunologic Diseases of the Skin offers clinicians a wide range of challenging cases that are certain to provide hours of thoughtful and instructive review. Using a case study format and including excellent quality color images, Challenging Cases in Allergic and Immunologic Diseases of the Skin consists of five parts and 20 chapters. The chapters cover such areas as allergic rhinitis, allergic diseases of the eye, drug-induced urticaria, cosmetic allergy, drug allergy, latex allergy, atopic dermatitis, vasculitis, and a range of other commonly seen disorders of the skin. Each chapter comprises at least two cases that are followed by a differential diagnosis, discussion, and five multiple choice questions for thoughtful stimulation and excellent value as a teaching tool. Comprehensive, concise, and well-designed in presentation, Challenging Cases in Allergic and Immunologic Diseases of the Skin is a one-of-a-kind resource that will become a standard resource for all clinicians who care for patients with allergic and immunologic diseases of the skin. 364 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -As minimal access approaches to cancer diagnosis, staging, and therapy become more widely used, it is vital for general surgeons, along with laparoscopists, surgical oncologists and medical oncologists, to stay up to date. The editors, a team consisting of a renowned surgical oncologist and a laparoscopic specialist, aim to provide a resource for the practicing general surgeon using basic minimally invasive techniques. The book discusses diagnosis including biopsy with microinstrumentation, staging, and palliative and curative resection. Specific tumor sites are addressed, including esophagus, stomach, spleen, small bowel, pancreato-biliary, hepatic resection, and colo-rectal resection. Minimally invasive approaches to the thoracic and retroperitoneal areas are included. The book provides a thorough overview of basic cancer biology, instrumentation, and ultrasound. Additionally, Greene and Heniford explore controversial issues such as port-site recurrence and the effect of pneumoperitoneum on the spread of cancer cells in the abdomen. Many photographs and line drawings, including 16 in full color, illustrate the principles discussed in the text. A must-have for every practicing general surgeon, laparoscopic fellow, and general surgery resident. 404 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In the spirit of Alladi Ramakrishnan's profound interest and contributions to three fields of science - Mathematics, Statistics, and Physics - this volume contains invited surveys and research articles from prominent members of these communities who also knew Ramakrishnan personally and greatly respected his influence in these areas of science. Historical photos, telegrams, and biographical narratives of Alladi Ramakrishnan's illustrious career of special interest are included as well. 596 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Molecular biology has rapidly advanced since the discovery of the basic flow of information in life, from DNA to RNA to proteins. While there are several important and interesting exceptions to this general flow of information, the importance of these biological macromolecules in dictating the phenotypic nature of living creatures in health and disease is paramount. In the last one and a half decades, and particularly after the completion of the Human Genome Project, there has been an explosion of technologies that allow the broad characterization of these macromolecules in physiology, and the perturbations to these macromolecules that occur in diseases such as cancer. In this volume, we will explore the modern approaches used to characterize these macromolecules in an unbiased, systematic way. Such technologies are rapidly advancing our knowledge of the coordinated and complicated changes that occur during carcinogenesis, and are providing vital information that, when correctly interpreted by biostatistical/bioinformatics analyses, can be exploited for the prevention, diagnosis, and treatment of human cancers.The purpose of this volume is to provide an overview of modern molecular biological approaches to unbiased discovery in cancer research. Advances in molecular biology allowing unbiased analysis of changes in cancer initiation and progression will be overviewed. These include the strategies employed in modern genomics, gene expression analysis, and proteomics. 204 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Angiogenesis (formation of new vessels from pre-existing ones) is a crucial early event in the process of tumor development. New vessels supply the tumor with nutrients that are needed for further local growth and enable distant metastases (Folkman 1995). Judah Folkman (1971) highlighted the potential therapeutic imp- cations of tumor angiogenesis. He hypothesized that if tumor angiogenesis is inhibited, then tumor growth and metastasis will be impaired greatly or even impossible. The subsequent quest for endogenous and exogenous inhibitors of angiogenesis has yielded a variety of promising therapeutic agents that block one or more angiogenic pathways, a few of which have been approved by the FDA (e. g. , bevacizumab, sorafenib, sunitinib) for use as single agents or in combination with chemotherapy in specific populations of cancer patients (Sessa et al. 2008). There has also been a dramatic expansion in the exploration of novel anti-angiogenic agents pre-clinically and in clinical trials (Ferrara 2002). Some of the most promising data comes from the development of agents that inhibit one of the key growth factors involved in tumor angiogenesis - vascular endothelial growth factor (VEGF) (Ferrara et al. 2003). Bevacizumab is a monoclonal antibody against VEGF that was the first an- angiogenic agent that improved significantly the overall survival of patients with colorectal and non-squamous non-small cell lung cancer (Ferrara et al. 2005). Various agents that target tumor angiogenesis are currently under investigation in different cancer types in many clinical trials (Ferrara and Kerbel 2005). 268 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Echinostomes are medically- and veterinary-important parasitic flatworms that invade humans, domestic animals and wildlife and also parasitize in their larval stages numerous invertebrate and cold-blooded vertebrate hosts. The interest in echinostomes in parasitology and general biology comes from several areas: (1) Human infections; (2) Experimental models; (3) Animal infections; (4) Systematics.The application of novel techniques is moving the echinostomes to the frontline of parasitology in fields such as systematics, immunobiology in vertebrate and invertebrate organisms and proteomics among others. The Biology of Echinostomes demonstrates the application of new techniques to a group of trematodes that may serve to obtain information of great value in parasitology and general biology. The book includes basic topics, such as biology and systematics, as well as more novel topics, such as immunobiology, proteomics, and genomics of echinostomes. The authors of each chapter emphasize their content with: (i) the most novel information obtained; (ii) analysis of this information in a more general context (i.e. general parasitology); and (iii) future perspectives in view of the information presented. The subjects are analyzed from a modern point of view, considering aspects such as applications of novel techniques and an analysis of host-parasite interactions. 348 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The book will synthesize and integrate better what are often disparate ideas, themes, and methods across substantive areas of white-collar crime and criminology and criminal justice. The book also puts together critical and emerging topics within criminology and criminal justice that have important implications for the study of white-collar crime and criminology/criminal justice more generally. 244 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Prostate cancer is the most common noncutaneous prostate cancer. Research has revealed several distinct malignancy and the second leading cause of cancer mechanisms of castration-resistant disease that may deaths among men in the United States. It is a critical converge in patients with disease progression on public health problem and remains incurable in the ADT. Many approaches are currently being evaluated metastatic setting with mortality that usually occurs as to improve the treatment of this condition and these a result of castration-resistant disease. fndings have identifed several potential targets for Since Huggins and Hodges' report of the dra- therapeutic intervention. These include drugs that are matic clinical effects of suppressing serum testos- more active or less toxic chemotherapy agents; drugs terone levels in men with advanced prostate cancer that induce androgen deprivation; drugs that target in 1941, hormone therapy (also called androgen the androgen receptor and/or androgen synthesis; deprivation therapy [ADT]) has become widely drugs that target specifc pathways, including ang- accepted as the mainstay of therapy for the treat- genesis and tyrosine kinase inhibitors, endothelin ment of advanced prostate cancer. ADT combined antagonists and matrix metalloproteinase inhibitors; with radiation therapy is a standard of care in the and immunologic approaches. Many of these agents treatment of men with locally advanced prostate seem promising and the rationale and effcacy of cancer on the basis of evidence that shows improved these emerging therapies remain to be validated in survival. The role of ADT in the management of future clinical trials. 448 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Collectively, neurodegenerative diseases are characterized by chronic and progressive loss of neurons in discrete areas of the brain, producing debilitating symptoms such as dementia, loss of memory, loss of sensory or motor capability, decreased overall quality of life eventually leading to premature death. Two types of cell death are known to occur during neurodegeneration: (a) apoptosis and (b) necrosis. The necrosis is characterized by the passive cell swelling, intense mitochondrial damage with rapid loss of ATP, alterations in neural membrane permeability, high calcium influx, and disruption of ion homeostasis. This type of cell death leads to membrane lysis and release of intracellular components that induce inflammatory reactions. Necrotic cell death normally occurs at the core of injury site. In contrast, apoptosis is an active process in which caspases (a group of endoproteases with specificity for aspartate residues in protein) are stimulated. Apoptotic cell death is accompanied by cell shrinkage, dynamic membrane blebbing, chromatin condensation, DNA laddering, loss of phospholipids asymmetry, low ATP levels, and mild calcium overload. This type of cell death normally occurs in penumbral region at the ischemic injury site and in different regions in various neurodegenerative diseases. 428 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Muscle contraction has been the focus of scientific investigation for more than two centuries, and major discoveries have changed the field over the years. Early in the twentieth century, Fenn (1924, 1923) showed that the total energy liberated during a contraction (heat + work) was increased when the muscle was allowed to shorten and perform work. The result implied that chemical reactions during contractions were load-dependent. The observation underlying the 'Fenn effect' was taken to a greater extent when Hill (1938) published a pivotal study showing in details the relation between heat production and the amount of muscle shortening, providing investigators with the force-velocity relation for skeletal muscles. Subsequently, two papers paved the way for the current paradigm in the field of muscle contraction. Huxley and Niedergerke (1954), and Huxley and Hanson (1954) showed that the width of the A-bands did not change during muscle stretch or activation. Contraction, previously believed to be caused by shortening of muscle filaments, was associated with sliding of the thick and thin filaments. These studies were followed by the classic paper by Huxley (1957), in which he conceptualized for the first time the cross-bridge theory; filament sliding was driven by the cyclical interactions of myosin heads (cross-bridges) with actin. The original cross-bridge theory has been revised over the years but the basic features have remained mostly intact. It now influences studies performed with molecular motors responsible for tasks as diverse as muscle contraction, cell division and vesicle transport. 368 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Since the first works introducing the aluminum intercalated clay family in the early 1970s, interest in the synthesis of pillared interlayered clays has increased tremendously, especially research into the properties and applications of new synthesis methods. The need for solids that could be used as cracking catalysts with larger pores than zeolitic materials has spurred the synthesis of new porous materials from clays. Pillared Clays and Related Catalysts reviews the properties and applications of pillared clays and other layered materials used as catalysts, focusing on:the acidity of pillared clays and the effect it has on catalytic performancethe use of pillared clays as supports for catalytically active phases, and the use of the resulting solids in environmentally friendly reactionsthe applications of the selective reduction of NOxthe comparison between the reactions of pillared clays and anionic clays. 540 pp. Englisch.