springer netherlands mrz 2011 (33 results)

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This brief represents a comprehensive review of methods for estimating characteristics of the foreign-born population in the United States, specifically oriented toward characteristics by legal status. A variety of methods have been proffered over the past many decades, in a large variety of venues; this work brings them together, attempts to impart some order on the definition of 'legal status,' and describes strengths and deficiencies both in methods and in data. The authors have a combined 50 years of experience in both demographic and statistical methodology. 56 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This important book breaks new ground in addressing issues of gendered learning in different contexts across the (adult) life span at the start of the 21st century. Adult learning sits within a shifting landscape of educational policy, profoundly influenced by the skills agenda, by complex funding policies, new qualifications and the widening/narrowing participation debate. The book is unique in highlighting the centrality of gendered choices to these developments which shape participation in and experiences of lifelong learning. Gendered Choices critically examines the continued expansion of a skills-based approach in areas of lifelong learning, including career decisions, professional identities and informal networks. It explores key intersections of adult learning from a gender perspective: notably participation, workplace learning and informal pathways.Drawing on research from a range of contexts, Gendered Choices demonstrates that for women the public/private spaces of work and home are often conflated, although the gendering of 'choice' has largely been ignored by policy makers.The themes of the book bring together some of these critical issues, explored through the multiple and fractured identities which constitute gendered lives. The book addresses these in an international context, with contributions from Canada, Spain and Iran that provide a wider international perspective on shared issues. 280 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Within educational research that seeks to understand the quality and effectiveness of teachers and school, the role emotions play in educational change and school improvement has become a subject of increasing importance. In this book, scholars from around the world explore the connections between teaching, teacher education, teacher emotions, educational change and school leadership. (For this text, 'teacher' encompasses pre-service teachers, in-service teachers and headteachers, or principals). New Understandings of Teacher's Work: Emotions and Educational Change is divided into four themes: educational change; teachers and teaching; teacher education; and emotions in leadership. The chapters address the key basic and substantive issues relative to the central emotional themes of the following: teachers' lives and careers in teaching; the role emotions play in teachers' work; lives and leadership roles in the context of educational reform; the working conditions; the context-specific dynamics of reform work; school/teacher cultures; individual biographies that affect teachers' emotional well-being; and the implications for the management and leadership of educational change, and for development, of teacher education. 268 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is part of a bold, new initiative towards global sustainability and development that draws on the disciplines of geotechnical engineering and earthquake geotechnics. It contains contributions from fifteen of the world's leading experts who met in Kyoto in early 2010 to discuss a range of issues related to the ways geotechnics can help us face the challenges ahead, from the technical to the social, from geo-hazards to megacities, from global warming and coastal protection to the conservation of world heritage sites. We hope these contributions will stimulate the debate over the role geotechnics has to play in achieving a more sustainable future for the world. AudienceThis book will be of interest to advanced levels of researchers and practicing engineers in the fields of geotechnics and earthquake geotechnics for global sustainability: the greatest long term challenge of our time. 276 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This unusual book considers physical principles, starting from the most general ones, and simplifies assumptions, helping students answer two key questions: what approximation is the simplest, but still sufficient for the description of a phenomenon in cosmic plasmas, and how to build an adequate model. 676 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Human-kind and ecological systems are currently facing one of the toughest challenges: how to feed more billions of people in the future within the perspective of climate change, energy shortages, economic crises and growing competition for the use of renewable and non renewable resources. This challenge is even more crucial given that we have not yet come close to achieving the Millennium Development Goal of halving the number of people living in extreme poverty and hunger.Scientists and relevant stakeholders are now voicing a clear message: that multiple challenges the world is facing require innovative, multifaceted, science-based, technological, economic and political approaches in theoretical thinking, decision making and action. With this background central to survival and well-being, the purpose of this volume is to formulate and promote relevant theoretical analysis and policy recommendations. The major perspective of this publication is that paradigm and policy shifts at all levels are needed urgently. This is based on the evidence that agriculture in the 21st century will be undergoing significant demands, arising largely from the need to increase the global food enterprise, while adjusting and contributing to climate change adaptation and mitigation. Global Food Insecurity aims at providing structure to effect achievement of this critically needed roadmap. 432 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 188 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The volume includes twenty-five research papers presented as gifts to John L. Bell to celebrate his 60th birthday by colleagues, former students, friends and admirers. Like Bell's own work, the contributions cross boundaries into several inter-related fields. The contributions are new work by highly respected figures, several of whom are among the key figures in their fields. Some examples: in foundations of maths and logic (William Lawvere, Peter Aczel, Graham Priest, Giovanni Sambin); analytical philosophy (Michael Dummett, William Demopoulos), philosophy of science (Michael Redhead, Frank Arntzenius), philosophy of mathematics (Michael Hallett, John Mayberry, Daniel Isaacson) and decision theory and foundations of economics (Ken Bimore). Most articles are contributions to current philosophical debates, but contributions also include some new mathematical results, important historical surveys, and a translation by Wilfrid Hodges of a key work of arabic logic. 508 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is a multi-author treatise on the most outstanding research problems in the field of the aeronomy of the Earth's atmosphere and ionosphere, encompassing the science covered by Division II of the International Association of Geomagnetism and Aeronomy (IAGA). It contains several review articles and detailed papers by leading scientists in the field. The book is organized in five parts: 1) Mesosphere-Lower Thermosphere Dynamics and Chemistry; 2) Vertical Coupling by Upward Propagating Waves; 3) Ionospheric Electrodynamics and Structuring; 4) Thermosphere- Ionosphere Coupling, Dynamics and Trends and 5) Ionosphere-Thermosphere Disturbances and Modeling. The book consolidates the progress achieved in the field in recent years and it serves as a useful reference for graduate students as well as experienced researchers. 504 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Simulation based on mathematical models plays a major role in computer aided design of integrated circuits (ICs). Decreasing structure sizes, increasing packing densities and driving frequencies require the use of refined mathematical models, and to take into account secondary, parasitic effects. This leads to very high dimensional problems which nowadays require simulation times too large for the short time-to-market demands in industry. Modern Model Order Reduction (MOR) techniques present a way out of this dilemma in providing surrogate models which keep the main characteristics of the device while requiring a significantly lower simulation time than the full model.With Model Reduction for Circuit Simulation we survey the state of the art in the challenging research field of MOR for ICs, and also address its future research directions. Special emphasis is taken on aspects stemming from miniturisations to the nano scale. Contributions cover complexity reduction using e.g., balanced truncation, Krylov-techniques or POD approaches. For semiconductor applications a focus is on generalising current techniques to differential-algebraic equations, on including design parameters, on preserving stability, and on including nonlinearity by means of piecewise linearisations along solution trajectories (TPWL) and interpolation techniques for nonlinear parts. Furthermore the influence of interconnects and power grids on the physical properties of the device is considered, and also top-down system design approaches in which detailed block descriptions are combined with behavioral models. Further topics consider MOR and the combination of approaches from optimisation and statistics, and the inclusion of PDE models with emphasis on MOR for the resulting partial differential algebraic systems. The methods which currently are being developed have also relevance in other application areas such as mechanical multibody systems, and systems arising in chemistry and to biology.The current number of books in the area of MOR for ICs is very limited, so that this volume helps to fill a gap in providing the state of the art material, and to stimulate further research in this area of MOR. Model Reduction for Circuit Simulation also reflects and documents the vivid interaction between three active research projects in this area, namely the EU-Marie Curie Action ToK project O-MOORE-NICE (members in Belgium, The Netherlands and Germany), the EU-Marie Curie Action RTN-project COMSON (members in The Netherlands, Italy, Germany, and Romania), and the German federal project System reduction in nano-electronics (SyreNe). 332 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Interweaving the human aspects of river control with analysis of hydro-physical data, including historical data over the last few centuries, this monograph is a comprehensive evaluation of the Damodar's lower reaches. While the Damodar River isn't an exceptional tropical river, nor does it feature classic examples of river control structures, it is unusual and worthy of study due to the fact that nowhere else in the tropical world have riverine sandbars been used as a resource base as well as for permanent settlements. Based on their knowledge of river stages, the inhabitants have fine-tuned their land use to flood events, applying a concept of flood zoning to the riverbed. Every available space has been utilized rationally and judiciously.This rare human-environmental study analyzes the remarkable way in which immigrants unfamiliar with the riverine environment have adapted to the altered hydrologic regime of the river. In doing so they have demonstrated a sophisticated understanding of the flood regime and the vagaries of an unpromising environment in their land use, cropping and settlement patterns. Spurred on by restricted social and economic mobility and sometimes political constraints, these self-settled refugees have learned to adapt to their environment and live with the floods.Bhattacharyya's text is particularly timely, as anthropogenic processes of this kind have not been adequately studied by geographers. 340 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Cell culture based research is important for our understanding of biological processes at the cellular and molecular level. Using this approach, the previous decades have produced a wealth of mechanistic information in all areas of biomedical research. Such in vitro research, however, lacks the complexity of in vivo investigations, where many different cell types interact with each other in a normal, three-dimensional environment, with normal levels of cytokines and growth factors. Furthermore, complex human diseases, such as cancer, diabetes or chronic inflammation, can only be modeled in vivo. Due to its small size, its short reproduction time, and the possibility to introduce specific gene mutations, the mouse has become the favourite mammalian model organism to study in vivo function of genes during development and in disease. This book combines review articles on selected subjects presented at the symposium 'Mouse as a Model Organism - From Animals to Cells', held in Rovaniemi, Finland, 2009. Among other topics, high-throughput phenotyping of mouse mutants, mouse phenotypes dependent on nature and nuture, and a spectrum of in vivo, ex vivo and in vitro methods to study cancer in mice are described. This book will give an excellent introduction to scientists interested in the use of mice as a model to understand complex biological questions in the post-genomic era. It will highlight the possibilities, but also discuss the current problems and shortcomings, to give a realistic view of the current state-of-art in this fascinating field of biomedical research. 180 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book presents results of scientific studies ranging from hydrological modelling to water management and policy issues in the Nile River basin. It examines the physical, hydrometeorological and hydrogeological description of the basin along with analysis in understanding the hydrological processes of the basin under the changing land-use stemming from population pressure and increased natural resources tapping. The book discusses the increased impact of climate change on the river flows, and such issues as water availability and demand, management and policy to offset the imbalance between demand and available resources.This book will be of interest to researchers, practitioners, water resources mangers, policy makers as well as graduate and undergraduate students. It is a useful reference text for ecohydrology, arid zone hydrology, hydrology of transboundary rivers and similar courses. 448 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Although cell fusion is an omnipresent process in life, to date considerably less is still known about the mechanisms and the molecules being involved in this biological phenomenon in higher organisms. In Cell Fusion in Health and Disease Vol 1 & Vol 2 leading experts will present up-to-date overviews about cell fusion in physiological and patho-physiological processes, which further covers the current knowledge about cell fusion-mediating molecules. Volume 1 deals with Cell Fusion in Health and will cover aspects of cell fusion in fertilization, placentation, in C. elegans, in skeletal muscle development and tissue repair, and the use of cell fusion for cellular reprogramming and cancer vaccine development. Volume 2 focuses on Cell Fusion in Disease with a particular emphasis on the role of cell fusion in cancer development and progression. Thus, Cell Fusion in Health and Disease Vol 1 & Vol 2 represents a state-of-the-art work for researchers, physicians or professionals being interested in the biological phenomenon of cell fusion and beyond. 204 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book focuses on a range of geospatial applications for environmental health research, including environmental justice issues, environmental health disparities, air and water contamination, and infectious diseases. Environmental health research is at an exciting point in its use of geotechnologies, and many researchers are working on innovative approaches. This book is a timely scholarly contribution in updating the key concepts and applications of using GIS and other geospatial methods for environmental health research. Each chapter contains original research which utilizes a geotechnical tool (Geographic Information Systems (GIS), remote sensing, GPS, etc.) to address an environmental health problem. The book is divided into three sections organized around the following themes: issues in GIS and environmental health research; using GIS to assess environmental health impacts; and geospatial methods for environmental health. Representing diverse case studies and geospatial methods, the book is likely to be of interest to researchers, practitioners and students across the geographic and environmental health sciences. The authors are leading researchers and practitioners in the field of GIS and environmental health. 512 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Regular Nanofabrics in Emerging Technologies gives a deep insight into both fabrication and design aspects of emerging semiconductor technologies, that represent potential candidates for the post-CMOS era. Its approach is unique, across different fields, and it offers a synergetic view for a public of different communities ranging from technologists, to circuit designers, and computer scientists. The book presents two technologies as potential candidates for future semiconductor devices and systems and it shows how fabrication issues can be addressed at the design level and vice versa. The reader either for academic or research purposes will find novel material that is explained carefully for both experts and non-initiated readers. Regular Nanofabrics in Emerging Technologies is a survey of post-CMOS technologies. It explains processing, circuit and system level design for people with various backgrounds. 212 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Currently, spatial analysis is becoming more important than ever because enormous volumes of spatial data are available from different sources, such as GPS, Remote Sensing, and others.This book deals with spatial analysis and modelling. It provides a comprehensive discussion of spatial analysis, methods, and approaches related to human settlements and associated environment. Key contributions with empirical case studies from Iran, Philippines, Vietnam, Thailand, Nepal, and Japan that apply spatial analysis including autocorrelation, fuzzy, voronoi, cellular automata, analytic hierarchy process, artificial neural network, spatial metrics, spatial statistics, regression, and remote sensing mapping techniques are compiled comprehensively. The core value of this book is a wide variety of results with state of the art discussion including empirical case studies.It provides a milestone reference to students, researchers, planners, and other practitioners dealing the spatial problems on urban and regional issues.We are pleased to announce that this book has been presented with the 2011 publishing award from the GIS Association of Japan.We would like to congratulate the authors! 312 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The book is based on lectures presented on the International Summer School on Biophysics held in Croatia in September 2009. The advantage of the School is that it provides advanced training in very broad scope of areas related to biophysics contrary to other similar schools or workshops that are centered mainly on one topic or technique. In this volume, tenth in the row, the papers in the field of biophysics are presented. The topics are biological phenomena from single protein to macromolecular aggregations structure by using variant physical methods (NMR, EPR, FTIR, Mass Spectrometry, etc.). The interrelationship of supramolecular structures and their functions is enlightened by applications of principals of these physical methods in the biophysical and molecular biology context. 164 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume provides a detailed description of a wide range of numerical, statistical or modeling techniques and novel instrumentation separated into individual chapters written by paleontologists with expertise in the given methodology. Each chapter outlines the strengths and limitations of specific numerical or technological approaches, and ultimately applies the chosen method to a real fossil dataset or sample type. A unifying theme throughout the book is the evaluation of fossils during the prologue and epilogue of one of the most exciting events in Earth History: the Cambrian radiation. 484 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume explores how vagueness matters as a specific problem in the context of theories that are primarily about something else. After an introductory chapter on the Sorites paradox, which exposes the various forms the paradox can take and some of the responses that have been pursued, the book proceeds with a chapter on vagueness and metaphysics, which covers important questions concerning vagueness that arise in connection with the deployment of certain key metaphysical notions. Subsequent chapters address the following: vagueness and logic, which discusses the sort of model theory that is suggested by the main, rival accounts of vagueness; vagueness and meaning, which focuses on contextualist, epistemicist, and indeterminist theories; vagueness and observationality; vagueness within linguistics, which focuses on approaches that take comparison classes into account; and the idea that vagueness in law is typically extravagant and that extravagant vagueness is a necessary feature of legal systems. 216 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -OF 'SOLIDARITY' IN UK SOCIAL WELFARE Here then, perhaps, is a British version of solidarity in social welfare, but early there are strong tensions between the powerfully liberal individualistic strands of the British understanding of the functions of the state and the socialistic or communitarian tendency of a commitment to universal welfare provision. In the search for the roots of this understanding of welfare we shall survey, fitst, the historical background to these tensions in some early British political philosophers, starting with Hobbes and ending with Mill. We then consider the philosophical and social influences on the Beveridge Report itself, and we will trace the emergence of the philosophy of the welfare state in the era following the Second World War. Finally we consider the contemporary debate, as it relates to the 'Third Way' thinking of New Labour. 2. A mSTORICAL SKETCH In the previous section we observed that the philosophy underlying the Beveridge Report could be described as 'liberal collectivism'. What are the historical antecedents of this strange amalgam of individualism and collectivism Within the short scope of this chapter, any account of the philosophical history must be little more than a sketch, but we can perhaps understand most debates in British socio-political thought as a continuing dialogue with the well known claim of Thomas Hobbes in Leviathan that all political institutions are founded on egoistic motives. 532 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book presents operational and practical issues of automotive mechatronics with special emphasis on the heterogeneous automotive vehicle systems approach, and is intended as a graduate text as well as a reference for scientists and engineers involved in the design of automotive mechatronic control systems.As the complexity of automotive vehicles increases, so does the dearth of high competence, multi-disciplined automotive scientists and engineers. This book provides a discussion into the type of mechatronic control systems found in modern vehicles and the skills required by automotive scientists and engineers working in this environment. Divided into two volumes and five parts, Automotive Mechatronics aims at improving automotive mechatronics education and emphasises the training of students' experimental hands-on abilities, stimulating and promoting experience among high education institutes and produce more automotive mechatronics and automation engineers. The main subject that are treated are: VOLUME I: RBW or XBW unibody or chassis-motion mechatronic control hypersystems; DBW AWD propulsion mechatronic control systems; BBW AWB dispulsion mechatronic control systems;VOLUME II: SBW AWS conversion mechatronic control systems; ABW AWA suspension mechatronic control systems.This volume was developed for undergraduate and postgraduate students as well as for professionals involved in all disciplines related to the design or research and development of automotive vehicle dynamics, powertrains, brakes, steering, and shock absorbers (dampers). Basic knowledge of college mathematics, college physics, and knowledge of the functionality of automotive vehicle basic propulsion, dispulsion, conversion and suspension systems is required. 540 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Myelodysplastic syndromes (MDS) are the most common hematological malignancies involving mostly the elderly population. The major morbidity relates to patients' symptomatic cytopenias.MDS was previously named as 'preleukemia ' or ' smoldering leukemia' as the lack of terminal cells in MDS and because about 25% of all cases progresses into acute myeloid leukemia.According to various reports the annual incidence of MDS ranges widely from 2-12 per 100.000, increasing to 30-50 cases per 100.000 among persons aged 70 or older. It is believed that the true incidence of MDS have been underestimated however it seems to be comparable to that for multiple myeloma and chronic lymphocytic leukemia. In the past decade much progress had been made; we know more on the disease pathology, there is more emphasis on the care and more targeted therapy had been invested. Athors provide updated knowledge in this book on all clinically important aspects of the disease. Hot topics of our days are discussed in chapters by outstanding and well known scientists from all over the world. We would offer this product both for medical students and postgraduates as well as for all who are interested in this very exciting and fast progressing field of hematology.With this work authors should call attention on the disease for decision makers in healt care systems as well. 300 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -A very complete survey of different approaches adopted by Eastern and Western countries for the disposal of surplus ammunition. Incineration and other techniques for the disposal of high explosives, gun and rocket propellants are introduced and discussed in relation to environmental and safety requirements. Proposals for and examples of the re-use of military explosives in commercial applications are given. Topics discussed range from the conversion of energetic systems into chemical raw materials to the new development of energetic systems with special features for commercial use (such as producing artificial diamonds by detonation, self-propagating high-temperature synthesis, fire extinguishing, etc.). 296 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Proceedings of the 3rd Joint International Conference on Hyperfine Interactions and International Symposium on Nuclear Quadrupole Interactions, HFI/NQI 2010 held at CERN, Switzerland, September 13-17, 2010 Reprinted from Hyperfine Interactions Volume. This volume focuses on the most recent studies on all aspects of hyperfine interaction detected by nuclear radiation and nuclear quadrupole interactions detected by resonance methods in the areas of materials, biological and medical science, as well as on contributions on new developments in instrumentation and methods, ab initio calculations and simulations. This volume comprises research papers, reviews, and short communications recording original investigations related to: Theory on Hyperfine Interactions (HFI) and Nuclear Moments; Magnetism and Magnetic Materials (Bulk and Thin Layers); HFI probes in Semiconductors, Metals and Insulators; Lattice Dynamics and Ion-Solid Interactions; Surfaces, Interfaces, Thin Films, and Nano-structures; Resonance Methods; Nuclear Moments, Nuclear Polarization and Spin Dynamics; Investigations in Biology, Chemistry, and Medicine; New Directions and Developments in Methodology. The papers present the latest scientific work of various invited speakers and contributor researchers from the five continents that have brought their perspectives to the meeting. 548 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Uniquely focusing on intersections of social problems, multilevel statistical modeling, and causality; the substantively and methodologically integrated chapters of this book clarify basic strategies for developing and testing multilevel linear models (MLMs), and drawing casual inferences from such models. These models are also referred to as hierarchical linear models (HLMs) or mixed models.The statistical modeling of multilevel data structures enables researchers to combine contextual and longitudinal analyses appropriately. But researchers working on social problems seldom apply these methods, even though the topics they are studying and the empirical data call for their use. By applying multilevel modeling to hierarchical data structures, this book illustrates how the use of these methods can facilitate social problems research and the formulation of social policies. It gives the reader access to working data sets, computer code, and analytic techniques, while at the same time carefully discussing issues of causality in such models.This book innovatively:-Develops procedures for studying social, economic, and human development.- Uses typologies to group (i.e., classify or nest) the level of random macro-level factors.- Estimates models with Poisson, binomial, and Gaussian end points using SAS's generalized linear mixed models (GLIMMIX) procedure.- Selects appropriate covariance structures for generalized linear mixed models.- Applies difference-in-differences study designs in the multilevel modeling of intervention studies.-Calculates propensity scores by applying Firth logistic regression to Goldberger-corrected data.- Uses the Kenward-Rogers correction in mixed models of repeated measures.- Explicates differences between associational and causal analysis of multilevel models.- Consolidates research findings via meta-analysis and methodological critique.-Develops criteria for assessing a study's validity and zone of causality.Because of its social problems focus, clarity of exposition, and use of state-of-the-art procedures; policy researchers, methodologists, and applied statisticians in the social sciences (specifically, sociology, social psychology, political science, education, and public health) will find this book of great interest. It can be used as a primary text in courses on multilevel modeling or as a primer for more advanced texts. 576 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential. Once cancer cells enter the liver, several different scenarios may occur. The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases. The chapters in Part I of this book provide insight into the cellular/molecular mechanisms that determine which of these scenarios prevails. Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact the early stages of the metastatic process. The unique microenvironment of the liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted. In addition, the role of inflammation (pre-existing and tumor-induced), host innate and adaptive immune responses, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with an underscoring of the translational implications of the current state of knowledge. Against this background, the chapters in Part II of the book provide critical reviews on major aspects of the clinical management of hepatic metastases. These include imaging strategies, surgical and chemotherapeutic treatment approaches and the use of targeted biological therapeutics such as anti-angiogenic drugs as treatment modalities. By combining information on biological and clinical aspects of liver metastasis, this volume will serve as an excellent resource for scientists, clinicians, clinician/ scientists and trainees in the domains of oncology, surgical oncology, hepatobiliary physiology and radiology. 460 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The most recent developments in diagnostic and therapeutic aspects of Gliomas (Glioblastoma) in the brain are presented. The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers is included. The identification and validation of brain cancer (glioblastoma) genes are discussed. Role of cancer stem cells in the initiation, progression, and persistence of malignant gliomas is explained. The use of surgical resection, chemotherapy (e.g., temozolomide), immunotherapy, and radiotherapy for malignant glioblastoma are pointed out. Standard (established) as well as newer imaging modalities (proton magnetic resonance spectroscopy) are discussed. 456 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Gamma-ray astronomy has undergone an enormous progress in the last 15 years. The success of satellite experiments like NASA's Comp ton Gamma-Ray Observatory and ESA's INTEGRAL mission, as well as of ground-based instruments have open new views into the high-energy Universe. Different classes of cosmic gamma-ray sources have been now detected at different energies, in addition to young radio pulsars and gamma-ray bursts, the classical ones. The new sources include radio quiet pulsars, microquasars, supernova remnants, starburst galaxies, ra dio galaxies, flat-spectrum radio quasars, and BL Lacertae objects. A large number of unidentified sources strongly suggests that this brief enumeration is far from complete. Gamma-ray bursts are now estab lished as extragalactic sources with tremendous energy output. There is accumulating evidence supporting the idea that massive stars and star forming regions can accelerate charged particles up to relativistic ener gies making them gamma-ray sources. Gamma-ray astronomy has also proved to be a powerful tool for cosmology imposing constraints to the background photon fields that can absorb the gamma-ray flux from dis tant sources. All this has profound implications for our current ideas about how particles are accelerated and transported in both the local and distant U niverse. The evolution of our knowledge on the gamma-ray sky has been so fast that is not easy for the non-specialist scientist and the graduate student to be aware of the full potential of this field or to grasp the fundamentals of a given topic in order to attempt some original contribution. 424 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book deals with linear functional differential equations and operator theory methods for their investigation. The main topics are: the equivalence of the input-output stability of the equation Lx = &mathsf; and the invertibility of the operator L in the class of casual operators; the equivalence of input-output and exponential stability; the equivalence of the dichotomy of solutions for the homogeneous equation Lx = 0 and the invertibility of the operator L; the properties of Green's function; the independence of the stability of an equation from the norm on the space of solutions; shift invariant functional differential equations in Banach space; the possibility of the reduction of an equation of neutral type to an equation of retarded type; special full subalgebras of integral and difference operators, and operators with unbounded memory; and the analogue of Fredholm's alternative for operators with almost periodic coefficients where one-sided invertibility implies two-sided invertibility. Audience: This monograph will be of interest to students and researchers working in functional differential equations and operator theory and is recommended for graduate level courses. 456 pp. Englisch.