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Published by VDM Verlag Dr. Müller, 2010
ISBN 10: 3639258940ISBN 13: 9783639258943
Seller: Lucky's Textbooks, Dallas, TX, U.S.A.
Book
Condition: New.
Published by VDM Verlag, 2010
ISBN 10: 3639258940ISBN 13: 9783639258943
Seller: Ria Christie Collections, Uxbridge, United Kingdom
Book Print on Demand
Condition: New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book.
Published by VDM Verlag 2010-06, 2010
ISBN 10: 3639258940ISBN 13: 9783639258943
Seller: Chiron Media, Wallingford, United Kingdom
Book
PF. Condition: New.
Published by VDM Verlag Dr. Müller, 2010
ISBN 10: 3639258940ISBN 13: 9783639258943
Seller: PBShop.store US, Wood Dale, IL, U.S.A.
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PAP. Condition: New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.
Published by VDM Verlag Dr. Müller, 2010
ISBN 10: 3639258940ISBN 13: 9783639258943
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
Book Print on Demand
Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The role of lipid rafts or glycosylphosphatidylinositol (GPI)- domains has been reported to be very important during T cell activation via clustering important molecular players, such as adhesion molecules, GPI-anchored proteins or signaling kinases. The main focus of my study is to explore the role of GPI-anchored proteins in activation of T cells. We have previously found that the GPI-anchored molecules, CD48 and CD59 behave differentially. Since CD2 has been shown to interact with CD48 in cis and trans configuration, I asked whether this interaction could be responsible for the differential behavior of CD48 and CD59. For this purpose I used the siRNA technology and down regulated CD2 and CD48 expression in Jurkat T cells. The knock- out cells showed altered recruitment of Lck, a Src family kinase (SFK) member, and LAT, a transmembrane adaptor protein (TRAP), to the TCR/CD3, decreased IL-2 promoter activity and decreased calcium flux as compared with the normal cells. Thus, these results show that CD2 and CD48 are not only important for recruitment of Lck and LAT but that they also interplay for association of these molecules and proper signal transduction. 96 pp. Englisch.
Published by VDM Verlag Dr. Müller, 2010
ISBN 10: 3639258940ISBN 13: 9783639258943
Seller: PBShop.store UK, Fairford, GLOS, United Kingdom
Book Print on Demand
PAP. Condition: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.
Published by VDM Verlag Dr. Müller, 2010
ISBN 10: 3639258940ISBN 13: 9783639258943
Seller: AHA-BUCH GmbH, Einbeck, Germany
Book Print on Demand
Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The role of lipid rafts or glycosylphosphatidylinositol (GPI)- domains has been reported to be very important during T cell activation via clustering important molecular players, such as adhesion molecules, GPI-anchored proteins or signaling kinases. The main focus of my study is to explore the role of GPI-anchored proteins in activation of T cells. We have previously found that the GPI-anchored molecules, CD48 and CD59 behave differentially. Since CD2 has been shown to interact with CD48 in cis and trans configuration, I asked whether this interaction could be responsible for the differential behavior of CD48 and CD59. For this purpose I used the siRNA technology and down regulated CD2 and CD48 expression in Jurkat T cells. The knock- out cells showed altered recruitment of Lck, a Src family kinase (SFK) member, and LAT, a transmembrane adaptor protein (TRAP), to the TCR/CD3, decreased IL-2 promoter activity and decreased calcium flux as compared with the normal cells. Thus, these results show that CD2 and CD48 are not only important for recruitment of Lck and LAT but that they also interplay for association of these molecules and proper signal transduction.
Published by VDM Verlag Dr. Müller, 2010
ISBN 10: 3639258940ISBN 13: 9783639258943
Seller: moluna, Greven, Germany
Book Print on Demand
Kartoniert / Broschiert. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Muhammad ArshadAfter earning Ph. D. degree from Medical University of Vienna, Austria in Molecular Immunology, Dr. Muhammad Arshad is working as Associate Professor in NUST Center of Virology and Immunology (NCVI), National Universit.
Published by VDM Verlag Dr. M ller, 2010
ISBN 10: 3639258940ISBN 13: 9783639258943
Seller: dsmbooks, Liverpool, United Kingdom
Book
paperback. Condition: Like New. Like New. book.