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Published by Raven Press, 1980
ISBN 10: 0890044589ISBN 13: 9780890044582
Seller: Zubal-Books, Since 1961, Cleveland, OH, U.S.A.
Book
Condition: Good. 414 pp., HARDCOVER, ex library, else text clean and binding tight. - If you are reading this, this item is actually (physically) in our stock and ready for shipment once ordered. We are not bookjackers. Buyer is responsible for any additional duties, taxes, or fees required by recipient's country.
Published by Springer, 2011
ISBN 10: 3642726690ISBN 13: 9783642726699
Seller: WorldofBooks, Goring-By-Sea, WS, United Kingdom
Book
Paperback. Condition: Very Good. The book has been read, but is in excellent condition. Pages are intact and not marred by notes or highlighting. The spine remains undamaged.
Published by Springer, 2013
ISBN 10: 3642252397ISBN 13: 9783642252396
Seller: Anybook.com, Lincoln, United Kingdom
Book
Condition: Good. Volumes 1 and 2. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. Clean from markings. In good all round condition. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,3450grams, ISBN:9783642252396.
Published by Lippincott Williams & Wilkins, 1980
ISBN 10: 0890044589ISBN 13: 9780890044582
Seller: Books Puddle, New York, NY, U.S.A.
Book
Condition: New. pp. 414 1st Edition.
Published by Lippincott Williams & Wilkins, 1980
ISBN 10: 0890044589ISBN 13: 9780890044582
Seller: Majestic Books, Hounslow, United Kingdom
Book
Condition: New. pp. 414.
Published by Springer Berlin Heidelberg, 2012
ISBN 10: 3642627129ISBN 13: 9783642627125
Seller: moluna, Greven, Germany
Book Print on Demand
Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung für Sie gedruckt. Von A bis Z erfolgreiches Software-HandlingOrientierungshilfe fuer den richtigen MethodenmixPraxis-Anleitung fuer mehr Software-Qualitaet und schnellere Entwick.
Published by Springer Berlin Heidelberg, 2011
ISBN 10: 3642726690ISBN 13: 9783642726699
Seller: Buchpark, Trebbin, Germany
Book
Condition: Sehr gut. Zustand: Sehr gut - Gepflegter, sauberer Zustand. | Seiten: 588 | Sprache: Deutsch.
Published by Springer, 2006
Seller: Antiquariat Thomas Haker GmbH & Co. KG, Berlin, Germany
Association Member: GIAQ
Book
Hardcover/Pappeinband. 920 p. Very good. Shrink wrapped. / Sehr guter Zustand. In Folie verschweißt. Sprache: Englisch Gewicht in Gramm: 2204.
Published by Springer, 2011
ISBN 10: 3642726690ISBN 13: 9783642726699
Seller: booksXpress, Bayonne, NJ, U.S.A.
Book
Soft Cover. Condition: new.
Published by Springer, 2011
ISBN 10: 3642726690ISBN 13: 9783642726699
Seller: Ria Christie Collections, Uxbridge, United Kingdom
Book Print on Demand
Condition: New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book.
Published by Springer 2011-12, 2011
ISBN 10: 3642726690ISBN 13: 9783642726699
Seller: Chiron Media, Wallingford, United Kingdom
Book
PF. Condition: New.
Published by Springer, 2011
ISBN 10: 3642726690ISBN 13: 9783642726699
Seller: Lucky's Textbooks, Dallas, TX, U.S.A.
Book
Condition: New.
Published by Springer Berlin Heidelberg Dez 2011, 2011
ISBN 10: 3642726690ISBN 13: 9783642726699
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
Book Print on Demand
Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Der Zusammenhang zwischen Dermatologie und Rheuma spielt in der Klinik eine große Rolle und erstreckt sich auf zahlreiche Fachgebiete. In diesem Buch wird dieses Thema von hervorragenden Fachwissenschaftlern ausführlich abgehandelt. Der thematische Bezug reicht von infekt- und medikamentenallergischen Haut- und Gelenkveränderungen über die psoriatische Skelettbeteiligung bis hin zu den sogenannten Kollagenosen, als deren wichtigster Vertreter die zirkumskripte und progressive systemische Sklerodermie gilt. In allen Beiträgen werden - soweit sie nicht die Grundlagenforschung betreffen - Diagnostik, Klinik und Therapie ausführlich besprochen. 588 pp. Deutsch.
Published by Springer Berlin Heidelberg, 2011
ISBN 10: 3642726690ISBN 13: 9783642726699
Seller: AHA-BUCH GmbH, Einbeck, Germany
Book
Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Der Zusammenhang zwischen Dermatologie und Rheuma spielt in der Klinik eine große Rolle und erstreckt sich auf zahlreiche Fachgebiete. In diesem Buch wird dieses Thema von hervorragenden Fachwissenschaftlern ausführlich abgehandelt. Der thematische Bezug reicht von infekt- und medikamentenallergischen Haut- und Gelenkveränderungen über die psoriatische Skelettbeteiligung bis hin zu den sogenannten Kollagenosen, als deren wichtigster Vertreter die zirkumskripte und progressive systemische Sklerodermie gilt. In allen Beiträgen werden - soweit sie nicht die Grundlagenforschung betreffen - Diagnostik, Klinik und Therapie ausführlich besprochen.
Published by Springer, 2011
ISBN 10: 3642726690ISBN 13: 9783642726699
Seller: Books Puddle, New York, NY, U.S.A.
Book
Condition: New. pp. 588.
Published by Springer Berlin Heidelberg, 2011
ISBN 10: 3642726690ISBN 13: 9783642726699
Seller: moluna, Greven, Germany
Book Print on Demand
Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Der Zusammenhang zwischen Dermatologie und Rheuma spielt in der Klinik eine grosse Rolle und erstreckt sich auf zahlreiche Fachgebiete. In diesem Buch wird dieses Thema von hervorragenden Fachwissenschaftlern ausfuehrlich abgehandelt. Der thematische Bezug re.
Published by Springer, 2010
ISBN 10: 3540898905ISBN 13: 9783540898900
Seller: ThriftBooks-Dallas, Dallas, TX, U.S.A.
Book
Hardcover. Condition: Fair. No Jacket. Readable copy. Pages may have considerable notes/highlighting. ~ ThriftBooks: Read More, Spend Less 2.9.
Published by Springer Berlin Heidelberg, 2010
ISBN 10: 3540898905ISBN 13: 9783540898900
Seller: moluna, Greven, Germany
Book Print on Demand
Gebunden. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. A landmark in the continuously changing world of drugsEasy-to-use, method-orientated overview on all aspects of Clinical PharmacologyEssential reading for pharmacologists, physicians, medicinal chemists and pharmacists at research institute.
Published by Springer Berlin Heidelberg Dez 2010, 2010
ISBN 10: 3540898905ISBN 13: 9783540898900
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
Book Print on Demand
Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series 'Drug Discovery and Evaluation' in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series 'Pharmacological Assays' comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume 'Safety and Pharmacokinetic Assays'. Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: 'Methods in Clinical Pharmacology'. 576 pp. Englisch.
Published by Springer Berlin Heidelberg, 2010
ISBN 10: 3540898905ISBN 13: 9783540898900
Seller: AHA-BUCH GmbH, Einbeck, Germany
Book
Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series 'Drug Discovery and Evaluation' in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series 'Pharmacological Assays' comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume 'Safety and Pharmacokinetic Assays'. Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: 'Methods in Clinical Pharmacology'.
Published by Springer, 2013
ISBN 10: 3642252397ISBN 13: 9783642252396
Seller: Basi6 International, Irving, TX, U.S.A.
Book
Condition: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.
Published by Springer, 2013
ISBN 10: 3642252397ISBN 13: 9783642252396
Seller: Books Puddle, New York, NY, U.S.A.
Book
Condition: New. pp. xxiv + 1404 2nd Edition.
Published by Springer 2010-12-15, 2010
ISBN 10: 3540898905ISBN 13: 9783540898900
Seller: Chiron Media, Wallingford, United Kingdom
Book
Hardcover. Condition: New.
Published by Springer Berlin Heidelberg, 2013
ISBN 10: 3642252397ISBN 13: 9783642252396
Seller: moluna, Greven, Germany
Book Print on Demand
Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. A landmark in the continuously changing world of drugsEssential reading for scientists and managers in the pharmaceutical industry involved in drug finding, drug development and decision making in the development processOf use for governmen.
Published by Springer, 2013
ISBN 10: 3642252397ISBN 13: 9783642252396
Seller: Majestic Books, Hounslow, United Kingdom
Book
Condition: New. pp. xxiv + 1404 243 Illus.
Published by Springer, 2013
ISBN 10: 3642252397ISBN 13: 9783642252396
Seller: GF Books, Inc., Hawthorne, CA, U.S.A.
Book
Condition: Good. Book is in Used-Good condition. Pages and cover are clean and intact. Used items may not include supplementary materials such as CDs or access codes. May show signs of minor shelf wear and contain limited notes and highlighting.
Published by Springer, 2013
ISBN 10: 3642252397ISBN 13: 9783642252396
Seller: GF Books, Inc., Hawthorne, CA, U.S.A.
Book
Condition: Fine. Book is in Used-LikeNew condition. Pages and cover are clean and intact. Used items may not include supplementary materials such as CDs or access codes. May show signs of minor shelf wear.
Published by Springer Berlin Heidelberg Feb 2013, 2013
ISBN 10: 3642252397ISBN 13: 9783642252396
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
Book Print on Demand
Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Safety aspects have become an outstanding issue in the process of drug discovery and development. Until 15 years ago safety aspects were addressed by pharmacological testing of the selected compound in high doses in tests directed at indications other than the intended indication of the new compound. These tests were followed by pharmacokinetic studies, which were mainly aimed at confirming of a suitable half-life time and at oral activity. Safety aspects relied mostly on toxicity studies, which however gave information on changes of organ structure rather than on organ function. Toxicological and pharmacokinetic studies were adapted to the progress of studies in clinical pharmacology and clinical trails. But the success rate in the pharmaceutical industry and the introduction of new chemical entities to the market per year dropped dramatically, whereas the development time for a new compound increased, sometimes exceeding the patent protection. A change of strategy was therefore adopted, involving the following changes: - Parallel instead of sequential involvement of the various disciplines (multidimensional compound optimization).- The term 'Safety Pharmacology' was coined. The International Conference on Harmonization (ICH) founded a Safety Pharmacology Working Group. Easily accessible and the most informative tests now have to be selected.- Exposure of a drug to the body by pharmacokinetic studies on absorption, distribution, metabolism and excretion has to be investigated at an early stage of development and can contribute to the selection of a compound for development. Toxicology experienced major achievements by the introduction of new methods, e.g., in silico methods, toxicogenomics and toxicoproteomics.The book is a landmark in the continuously changing world of drugs. As such it is important reading for many groups: not only for all students of pharmacology and toxicology but also for physicians, especially those involved in clinical trials of drugs, and for pharmacists who have to know the safety requirements of drugs.The book is absolutely essential for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process.In particular, the book will be of use for government institutions and committees working on official guidelines for drug evaluation worldwide. 1452 pp. Englisch.
Published by Springer Berlin Heidelberg, 2013
ISBN 10: 3642252397ISBN 13: 9783642252396
Seller: AHA-BUCH GmbH, Einbeck, Germany
Book
Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Safety aspects have become an outstanding issue in the process of drug discovery and development. Until 15 years ago safety aspects were addressed by pharmacological testing of the selected compound in high doses in tests directed at indications other than the intended indication of the new compound. These tests were followed by pharmacokinetic studies, which were mainly aimed at confirming of a suitable half-life time and at oral activity. Safety aspects relied mostly on toxicity studies, which however gave information on changes of organ structure rather than on organ function. Toxicological and pharmacokinetic studies were adapted to the progress of studies in clinical pharmacology and clinical trails. But the success rate in the pharmaceutical industry and the introduction of new chemical entities to the market per year dropped dramatically, whereas the development time for a new compound increased, sometimes exceeding the patent protection. A change of strategy was therefore adopted, involving the following changes: - Parallel instead of sequential involvement of the various disciplines (multidimensional compound optimization).- The term 'Safety Pharmacology' was coined. The International Conference on Harmonization (ICH) founded a Safety Pharmacology Working Group. Easily accessible and the most informative tests now have to be selected.- Exposure of a drug to the body by pharmacokinetic studies on absorption, distribution, metabolism and excretion has to be investigated at an early stage of development and can contribute to the selection of a compound for development. Toxicology experienced major achievements by the introduction of new methods, e.g., in silico methods, toxicogenomics and toxicoproteomics.The book is a landmark in the continuously changing world of drugs. As such it is important reading for many groups: not only for all students of pharmacology and toxicology but also for physicians, especially those involved in clinical trials of drugs, and for pharmacists who have to know the safety requirements of drugs.The book is absolutely essential for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process.In particular, the book will be of use for government institutions and committees working on official guidelines for drug evaluation worldwide.
Published by Springer, 2013
ISBN 10: 3642252397ISBN 13: 9783642252396
Seller: Mispah books, Redhill, SURRE, United Kingdom
Book
Hardcover. Condition: Like New. Like New. book.