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Published by Stuttgart : Enke, 1992
ISBN 10: 3432999518ISBN 13: 9783432999517
Seller: books4less (Versandantiquariat Petra Gros GmbH & Co. KG), Welling, Germany
Book
Broschiert. Condition: Gut. 242 S. ; Der Erhaltungszustand des hier angebotenen Werks ist trotz seiner Bibliotheksnutzung sehr sauber. Es befindet sich neben dem Rückenschild lediglich ein Bibliotheksstempel im Buch; ordnungsgemäß entwidmet. Sprache: Deutsch Gewicht in Gramm: 400.
Published by Enke, F, 1992
ISBN 10: 3432999518ISBN 13: 9783432999517
Seller: Antiquariat Bookfarm, Löbnitz, Germany
Book
Softcover. 244 S. Ehem. Bibliotheksexemplar mit üblichen Merkmalen wie Signatur und Stempel. Moderate Lager- und Gebrauchsspuren. Vereinzelte kleinere Anstreichungen und Marginalien möglich, ansonsten textsauberes Exemplar in gutem Zustand. 9783432999517 Sprache: Deutsch Gewicht in Gramm: 380.
Published by Lucius & Lucius, 1992
ISBN 10: 3432999518ISBN 13: 9783432999517
Seller: NEPO UG, Rüsselsheim am Main, Germany
Book
Broschiert. Condition: Gut. Sofort verfügbar / Versand am folgenden Arbeitstag / mit Rechnung / daily shipping worldwide with invoice / ex library / aus Bibliothek / Sprache: Deutsch Gewicht in Gramm: 550.
Published by Berlin Kirschkern 1 Auflage, 1979
Seller: Antiquariat Maralt, Boitzenburger Land, UM, Germany
gr. 8° - 278 S. OKtn., einige Abb., sehr gutes Exemplar, ohne Einträge. Sprache: Deutsch 400 gr.
Published by Springer, 2013
ISBN 10: 3642252397ISBN 13: 9783642252396
Seller: Anybook.com, Lincoln, United Kingdom
Book
Condition: Good. Volumes 1 and 2. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. Clean from markings. In good all round condition. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,3450grams, ISBN:9783642252396.
Published by Hannover, Comic Club Hannover, 1994
Seller: Versand-Antiquariat Konrad von Agris e.K., Aachen, Germany
Comic
8° Broschiert. Condition: Wie neu. 22 S. Zustand wie neu. Weitere Ausgaben verfügbar. Konvolutpreise können erfragt werden. . Als Versandart wählen wir immer eine schnelle Option (in Deutschland Brief oder DHL-Paket, ins Ausland Warenpost oder DHL-Paket). Preis inkl. MwSt. Sprache: Deutsch Gewicht in Gramm: 48.
Published by Hannover, Comic Club Hannover, 1994
Seller: Versand-Antiquariat Konrad von Agris e.K., Aachen, Germany
Comic
8° Broschiert. Condition: Wie neu. 22 S. Zustand wie neu. Weitere CCH-Sonderhefte verfügbar. Konvolutpreise können erfragt werden. . Als Versandart wählen wir immer eine schnelle Option (in Deutschland Brief oder DHL-Paket, ins Ausland Warenpost oder DHL-Paket). Preis inkl. MwSt. Sprache: Deutsch Gewicht in Gramm: 47.
Published by Springer, 2006
Seller: Antiquariat Thomas Haker GmbH & Co. KG, Berlin, Germany
Association Member: GIAQ
Book
Hardcover/Pappeinband. 920 p. Very good. Shrink wrapped. / Sehr guter Zustand. In Folie verschweißt. Sprache: Englisch Gewicht in Gramm: 2204.
Published by Springer, 2010
ISBN 10: 3540898905ISBN 13: 9783540898900
Seller: ThriftBooks-Dallas, Dallas, TX, U.S.A.
Book
Hardcover. Condition: Fair. No Jacket. Readable copy. Pages may have considerable notes/highlighting. ~ ThriftBooks: Read More, Spend Less 2.9.
Published by Springer Berlin Heidelberg, 2010
ISBN 10: 3540898905ISBN 13: 9783540898900
Seller: Buchpark, Trebbin, Germany
Book
Condition: Sehr gut. Zustand: Sehr gut - Neubindung, Buchschnitt leicht verkürzt, Buchecken leicht angestoßen, Buchumschlag leicht zerkratzt | Seiten: 576 | Sprache: Englisch.
Published by Springer Berlin Heidelberg, 2010
ISBN 10: 3540898905ISBN 13: 9783540898900
Seller: moluna, Greven, Germany
Book Print on Demand
Gebunden. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. A landmark in the continuously changing world of drugsEasy-to-use, method-orientated overview on all aspects of Clinical PharmacologyEssential reading for pharmacologists, physicians, medicinal chemists and pharmacists at research institute.
Published by Springer Berlin Heidelberg Dez 2010, 2010
ISBN 10: 3540898905ISBN 13: 9783540898900
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
Book Print on Demand
Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series 'Drug Discovery and Evaluation' in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series 'Pharmacological Assays' comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume 'Safety and Pharmacokinetic Assays'. Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: 'Methods in Clinical Pharmacology'. 576 pp. Englisch.
Published by Springer Berlin Heidelberg, 2010
ISBN 10: 3540898905ISBN 13: 9783540898900
Seller: AHA-BUCH GmbH, Einbeck, Germany
Book
Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series 'Drug Discovery and Evaluation' in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series 'Pharmacological Assays' comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume 'Safety and Pharmacokinetic Assays'. Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: 'Methods in Clinical Pharmacology'.
Published by Springer, 2013
ISBN 10: 3642252397ISBN 13: 9783642252396
Seller: Basi6 International, Irving, TX, U.S.A.
Book
Condition: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.
Published by Springer Berlin Heidelberg, 2013
ISBN 10: 3642252397ISBN 13: 9783642252396
Seller: Buchpark, Trebbin, Germany
Book
Condition: Sehr gut. Zustand: Sehr gut - Buchschnitt verkürzt- gepflegter, sauberer Zustand - Ausgabejahr 2013 | Seiten: 1452 | Sprache: Englisch.
Published by Springer, 2013
ISBN 10: 3642252397ISBN 13: 9783642252396
Seller: Books Puddle, New York, NY, U.S.A.
Book
Condition: New. pp. xxiv + 1404 2nd Edition.
Published by Springer 2010-12-15, 2010
ISBN 10: 3540898905ISBN 13: 9783540898900
Seller: Chiron Media, Wallingford, United Kingdom
Book
Hardcover. Condition: New.
Published by Springer Berlin Heidelberg, 2013
ISBN 10: 3642252397ISBN 13: 9783642252396
Seller: moluna, Greven, Germany
Book Print on Demand
Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. A landmark in the continuously changing world of drugsEssential reading for scientists and managers in the pharmaceutical industry involved in drug finding, drug development and decision making in the development processOf use for governmen.
Published by Springer, 2013
ISBN 10: 3642252397ISBN 13: 9783642252396
Seller: Majestic Books, Hounslow, United Kingdom
Book
Condition: New. pp. xxiv + 1404 243 Illus.
Published by Springer Berlin Heidelberg Feb 2013, 2013
ISBN 10: 3642252397ISBN 13: 9783642252396
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
Book Print on Demand
Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Safety aspects have become an outstanding issue in the process of drug discovery and development. Until 15 years ago safety aspects were addressed by pharmacological testing of the selected compound in high doses in tests directed at indications other than the intended indication of the new compound. These tests were followed by pharmacokinetic studies, which were mainly aimed at confirming of a suitable half-life time and at oral activity. Safety aspects relied mostly on toxicity studies, which however gave information on changes of organ structure rather than on organ function. Toxicological and pharmacokinetic studies were adapted to the progress of studies in clinical pharmacology and clinical trails. But the success rate in the pharmaceutical industry and the introduction of new chemical entities to the market per year dropped dramatically, whereas the development time for a new compound increased, sometimes exceeding the patent protection. A change of strategy was therefore adopted, involving the following changes: - Parallel instead of sequential involvement of the various disciplines (multidimensional compound optimization).- The term 'Safety Pharmacology' was coined. The International Conference on Harmonization (ICH) founded a Safety Pharmacology Working Group. Easily accessible and the most informative tests now have to be selected.- Exposure of a drug to the body by pharmacokinetic studies on absorption, distribution, metabolism and excretion has to be investigated at an early stage of development and can contribute to the selection of a compound for development. Toxicology experienced major achievements by the introduction of new methods, e.g., in silico methods, toxicogenomics and toxicoproteomics.The book is a landmark in the continuously changing world of drugs. As such it is important reading for many groups: not only for all students of pharmacology and toxicology but also for physicians, especially those involved in clinical trials of drugs, and for pharmacists who have to know the safety requirements of drugs.The book is absolutely essential for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process.In particular, the book will be of use for government institutions and committees working on official guidelines for drug evaluation worldwide. 1452 pp. Englisch.
Published by Springer Berlin Heidelberg, 2013
ISBN 10: 3642252397ISBN 13: 9783642252396
Seller: AHA-BUCH GmbH, Einbeck, Germany
Book
Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Safety aspects have become an outstanding issue in the process of drug discovery and development. Until 15 years ago safety aspects were addressed by pharmacological testing of the selected compound in high doses in tests directed at indications other than the intended indication of the new compound. These tests were followed by pharmacokinetic studies, which were mainly aimed at confirming of a suitable half-life time and at oral activity. Safety aspects relied mostly on toxicity studies, which however gave information on changes of organ structure rather than on organ function. Toxicological and pharmacokinetic studies were adapted to the progress of studies in clinical pharmacology and clinical trails. But the success rate in the pharmaceutical industry and the introduction of new chemical entities to the market per year dropped dramatically, whereas the development time for a new compound increased, sometimes exceeding the patent protection. A change of strategy was therefore adopted, involving the following changes: - Parallel instead of sequential involvement of the various disciplines (multidimensional compound optimization).- The term 'Safety Pharmacology' was coined. The International Conference on Harmonization (ICH) founded a Safety Pharmacology Working Group. Easily accessible and the most informative tests now have to be selected.- Exposure of a drug to the body by pharmacokinetic studies on absorption, distribution, metabolism and excretion has to be investigated at an early stage of development and can contribute to the selection of a compound for development. Toxicology experienced major achievements by the introduction of new methods, e.g., in silico methods, toxicogenomics and toxicoproteomics.The book is a landmark in the continuously changing world of drugs. As such it is important reading for many groups: not only for all students of pharmacology and toxicology but also for physicians, especially those involved in clinical trials of drugs, and for pharmacists who have to know the safety requirements of drugs.The book is absolutely essential for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process.In particular, the book will be of use for government institutions and committees working on official guidelines for drug evaluation worldwide.
Published by Springer, 2013
ISBN 10: 3642252397ISBN 13: 9783642252396
Seller: Mispah books, Redhill, SURRE, United Kingdom
Book
Hardcover. Condition: Like New. Like New. book.