Items related to Toxicogenomics
The meteoric rate at which the human genome is being sequenced has presented to the research community a vast array of newly discovered genes, which in tum has catalyzed an even more dramatic effort to decipher this voluminous data set into understanding how genes function both individually and in complex pathways that regulate the biochemistry of life. A compendium of gene expression data, enhanced by complete proteomic analysis, will enable investigators to probe into the complexities of the mechanisms of normal genetic and metabolic pathways and, subsequently, how disease occurs when they malfunction. The new science of toxicogenomics combines genomic, proteomic, and informatics technologies, and biological research can now foresee a time when there will be a full comprehension of the complex dynamic mechanisms of genetics, biochemistry, and physiology. The inherent power of toxicogenomics derives from an amalgamation of multiple scientific disciplines that were originally drawn together to facilitate sequencing the three billion bases that comprise the human genome. Traditionally, the science of toxicology has been founded upon empirical codification of dose-related effects. It has evolved to studies that are directed towards understanding the mechanisms by which individual agents cause their effects in humans. Due to technical limitations, this process has been relatively slow, since it has accomplished one chemical or one effect at a time.
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Toxicogenomics is a new multidisciplinary field concerned with elucidating how the entire genome is involved in biological responses of organisms exposed to environmental toxicants and stressors. Toxicogenomics combines information from studies of genomic-scale mRNA profiling by microarray analysis, cell-wide or tissue-wide protein profiling (proteomics), genetic susceptibility related to single nucleotide polymorphism, and computational models to understand the roles of gene-environment interactions. This book makes a valuable addition to the laboratory bookshelf of all scientists and practitioners studying toxicology, environmental science, drug development, and pharmaceutical safety. As toxicogenomics makes a revolutionary impact on environmental health, drug safety, and risk assessment in 21st-century toxicology, this volume serves as an essential sourcebook.
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- PublisherSpringer
- Publication date2002
- ISBN 10 4431703446
- ISBN 13 9784431703440
- BindingHardcover
- Number of pages251
- EditorInoue Tohru, Pennie William T.
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Book Description Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The meteoric rate at which the human genome is being sequenced has presented to the research community a vast array of newly discovered genes, which in tum has catalyzed an even more dramatic effort to decipher this voluminous data set into understanding how genes function both individually and in complex pathways that regulate the biochemistry of life. A compendium of gene expression data, enhanced by complete proteomic analysis, will enable investigators to probe into the complexities of the mechanisms of normal genetic and metabolic pathways and, subsequently, how disease occurs when they malfunction. The new science of toxicogenomics combines genomic, proteomic, and informatics technologies, and biological research can now foresee a time when there will be a full comprehension of the complex dynamic mechanisms of genetics, biochemistry, and physiology. The inherent power of toxicogenomics derives from an amalgamation of multiple scientific disciplines that were originally drawn together to facilitate sequencing the three billion bases that comprise the human genome. Traditionally, the science of toxicology has been founded upon empirical codification of dose-related effects. It has evolved to studies that are directed towards understanding the mechanisms by which individual agents cause their effects in humans. Due to technical limitations, this process has been relatively slow, since it has accomplished one chemical or one effect at a time. 256 pp. Englisch. Seller Inventory # 9784431703440
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Book Description Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. This book provides the most up-to-date information on toxicogenomics, the field that opens new paradigm of toxicology by comprehensive DNA chip and microarray technologies.The meteoric rate at which the human genome is being sequenced has presented to t. Seller Inventory # 449822276
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Book Description Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - The meteoric rate at which the human genome is being sequenced has presented to the research community a vast array of newly discovered genes, which in tum has catalyzed an even more dramatic effort to decipher this voluminous data set into understanding how genes function both individually and in complex pathways that regulate the biochemistry of life. A compendium of gene expression data, enhanced by complete proteomic analysis, will enable investigators to probe into the complexities of the mechanisms of normal genetic and metabolic pathways and, subsequently, how disease occurs when they malfunction. The new science of toxicogenomics combines genomic, proteomic, and informatics technologies, and biological research can now foresee a time when there will be a full comprehension of the complex dynamic mechanisms of genetics, biochemistry, and physiology. The inherent power of toxicogenomics derives from an amalgamation of multiple scientific disciplines that were originally drawn together to facilitate sequencing the three billion bases that comprise the human genome. Traditionally, the science of toxicology has been founded upon empirical codification of dose-related effects. It has evolved to studies that are directed towards understanding the mechanisms by which individual agents cause their effects in humans. Due to technical limitations, this process has been relatively slow, since it has accomplished one chemical or one effect at a time. Seller Inventory # 9784431703440
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Book Description Condition: New. Toxicogenomics is a multidisciplinary field concerned with elucidating how the entire genome is involved in biological responses of organisms exposed to environmental toxicants and stressors. Editor(s): Inoue, Tohru; Pennie, William D.; Penni, W.D. Num Pages: 228 pages, biography. BIC Classification: MFN; MMGT. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly. Dimension: 235 x 155 x 16. Weight in Grams: 549. . 2002. Hardback. . . . . Seller Inventory # V9784431703440
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