Items related to Teashirt in cell proliferation: Analysis of tsh mutants...
Here we present evidence that the transcription factor Teashirt (Tsh) has a role in cell proliferation in Drosophila follicle stem cells (FSC), neuroblasts and S2 cells. In ovaries, Tsh and Hedgehog (Hh) are co-expressed in the terminal filament and cap cells. The characterisation of a new tsh mutation causing female sterility allowed us to show that Tsh acts via Hh-mediated signalling pathway to control FSC proliferation. In this tsh background, the hsGal4 driven expression of tsh or hh partially rescues the abnormal phenotype allowing oogenesis progression. Furthermore, tsh overexpression mimics the hh overexpression associated phenotype. In neuroblasts, mutant tsh alleles are unable to exit mitosis. The phenotypes of double mutants with rod or bub1 resemble the tsh single mutant phenotype, suggesting failure to escape mitosis. Finally, tsh depletion in S2 cells mimics the tsh mutant phenotype in neuroblasts. We propose that during oogenesis, tsh affects FSC proliferation mediating Hh expression. In neuroblasts, tsh may also acts through Hh signalling, since expression of interference hedgehog, was severely downregulated in our DNA microarray analysis.
"synopsis" may belong to another edition of this title.
About the Author:
Dr. Silvia Pimentel has obtained her PhD degree in 2011, here is shown her PhD results. Dr. Rui Gomes (PhD degree in 1994) Professor at Lisbon University (FCUL) works in the fields of Cell Cycle Regulation and Neurosciences. Dr. Laurent Fasano (PhD degree in 1990) CNRS Researcher at the IBDML works in the field of Developmental Biology.
"About this title" may belong to another edition of this title.
- PublisherLAP LAMBERT Academic Publishing
- Publication date2012
- ISBN 10 3848428504
- ISBN 13 9783848428502
- BindingPaperback
- Number of pages200
Buy New
Learn more about this copy
£ 57.36
Shipping:
£ 3.19
Within U.S.A.
Top Search Results from the AbeBooks Marketplace
Stock Image
Teashirt in cell proliferation: Analysis of tsh mutants in Drosophila melanogaster
Published by
LAP LAMBERT Academic Publishing
(2012)
ISBN 10: 3848428504
ISBN 13: 9783848428502
New
Softcover
Quantity: > 20
Seller:
Rating
Book Description Condition: New. Seller Inventory # ABLIING23Apr0316110143633
Buy New
£ 57.36
Convert currency
Stock Image
Teashirt in Cell Proliferation
Published by
LAP Lambert Academic Publishing
(2012)
ISBN 10: 3848428504
ISBN 13: 9783848428502
New
Softcover
Quantity: > 20
Seller:
Rating
Book Description Condition: New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book. Seller Inventory # ria9783848428502_lsuk
Buy New
£ 61.92
Convert currency
Stock Image
Teashirt in Cell Proliferation
Published by
LAP Lambert Academic Publishing 2012-03
(2012)
ISBN 10: 3848428504
ISBN 13: 9783848428502
New
PF
Quantity: 10
Seller:
Rating
Book Description PF. Condition: New. Seller Inventory # 6666-IUK-9783848428502
Buy New
£ 57.77
Convert currency
Seller Image
Teashirt in cell proliferation
Published by
LAP LAMBERT Academic Publishing Mrz 2012
(2012)
ISBN 10: 3848428504
ISBN 13: 9783848428502
New
Taschenbuch
Quantity: 2
Seller:
Rating
Book Description Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Here we present evidence that the transcription factor Teashirt (Tsh) has a role in cell proliferation in Drosophila follicle stem cells (FSC), neuroblasts and S2 cells. In ovaries, Tsh and Hedgehog (Hh) are co-expressed in the terminal filament and cap cells. The characterisation of a new tsh mutation causing female sterility allowed us to show that Tsh acts via Hh-mediated signalling pathway to control FSC proliferation. In this tsh background, the hsGal4 driven expression of tsh or hh partially rescues the abnormal phenotype allowing oogenesis progression. Furthermore, tsh overexpression mimics the hh overexpression associated phenotype. In neuroblasts, mutant tsh alleles are unable to exit mitosis. The phenotypes of double mutants with rod or bub1 resemble the tsh single mutant phenotype, suggesting failure to escape mitosis. Finally, tsh depletion in S2 cells mimics the tsh mutant phenotype in neuroblasts. We propose that during oogenesis, tsh affects FSC proliferation mediating Hh expression. In neuroblasts, tsh may also acts through Hh signalling, since expression of interference hedgehog, was severely downregulated in our DNA microarray analysis. 200 pp. Englisch. Seller Inventory # 9783848428502
Buy New
£ 59.82
Convert currency
Stock Image
Teashirt in cell proliferation Analysis of tsh mutants in Drosophila melanogaster
Published by
LAP LAMBERT Academic Publishing
(2012)
ISBN 10: 3848428504
ISBN 13: 9783848428502
New
PAP
Quantity: > 20
Seller:
Rating
Book Description PAP. Condition: New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Seller Inventory # L0-9783848428502
Buy New
£ 82.22
Convert currency
Stock Image
Teashirt in cell proliferation Analysis of tsh mutants in Drosophila melanogaster
Published by
LAP LAMBERT Academic Publishing
(2012)
ISBN 10: 3848428504
ISBN 13: 9783848428502
New
PAP
Quantity: > 20
Seller:
Rating
Book Description PAP. Condition: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Seller Inventory # L0-9783848428502
Buy New
£ 62.12
Convert currency
Seller Image
Teashirt in cell proliferation : Analysis of tsh mutants in Drosophila melanogaster
Published by
LAP LAMBERT Academic Publishing
(2012)
ISBN 10: 3848428504
ISBN 13: 9783848428502
New
Taschenbuch
Quantity: 1
Seller:
Rating
Book Description Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Here we present evidence that the transcription factor Teashirt (Tsh) has a role in cell proliferation in Drosophila follicle stem cells (FSC), neuroblasts and S2 cells. In ovaries, Tsh and Hedgehog (Hh) are co-expressed in the terminal filament and cap cells. The characterisation of a new tsh mutation causing female sterility allowed us to show that Tsh acts via Hh-mediated signalling pathway to control FSC proliferation. In this tsh background, the hsGal4 driven expression of tsh or hh partially rescues the abnormal phenotype allowing oogenesis progression. Furthermore, tsh overexpression mimics the hh overexpression associated phenotype. In neuroblasts, mutant tsh alleles are unable to exit mitosis. The phenotypes of double mutants with rod or bub1 resemble the tsh single mutant phenotype, suggesting failure to escape mitosis. Finally, tsh depletion in S2 cells mimics the tsh mutant phenotype in neuroblasts. We propose that during oogenesis, tsh affects FSC proliferation mediating Hh expression. In neuroblasts, tsh may also acts through Hh signalling, since expression of interference hedgehog, was severely downregulated in our DNA microarray analysis. Seller Inventory # 9783848428502
Buy New
£ 59.82
Convert currency
Seller Image
Teashirt in cell proliferation
Published by
LAP LAMBERT Academic Publishing
(2012)
ISBN 10: 3848428504
ISBN 13: 9783848428502
New
Kartoniert / Broschiert
Quantity: > 20
Seller:
Rating
Book Description Kartoniert / Broschiert. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Pimentel SilviaDr. Silvia Pimentel has obtained her PhD degree in 2011, here is shown her PhD results. Dr. Rui Gomes (PhD degree in 1994) Professor at Lisbon University (FCUL) works in the fields of Cell Cycle Regulation and Neurosci. Seller Inventory # 5521500
Buy New
£ 48.57
Convert currency