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The natural products from plants still remain an important source of pharmaceuticals. In the current study, bark and wood extracts of Ficus elastica aerial roots were screened for anti-cancer activity. Three new compounds, ficusamide, ficusoside and elasticoside, were isolated from the bark of aerial roots, together with nine known compounds. Three new compounds, elasticamide, elastiquinone and ficusoside B, together with four known compounds, were isolated from the wood of aerial roots. The structures of the new compounds were established by means of extensive spectroscopic analyses and by data with those reported for structurally related molecules. The isolated compounds were afterwards evaluated for their anti-proliferative effect on six human cancer cell lines using colorimetric MTT assay. Most notably, elastiquinone showed cytotoxic activity with IC50 = 14 µM against B16F10 melanoma cells, whereas the peracetylated form of ficusoside B displayed the lowest IC50 value (11 µM) against U373n glioma cell lines. The results of this investigation demonstrate that F. elastica might be a potential source for identifying new compounds with potent anti-proliferative activity.
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Lecturer-researcher, Emmanuel MBOSSO holds a Doctorate/Ph.D in Org. Chem. obtained under joint supervision between Univ. of Yaounde I (Cameroon) and the Univ. of Strasbourg (France). After his visit to the Babes-Bolyai Univ. (Romania) and ULB (Belgium) as a postdoc, he is currently Senior Lecturer at Univ. of Douala and Scientific Collaborator ULB.
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- PublisherÉditions universitaires européennes
- Publication date2016
- ISBN 10 384161650X
- ISBN 13 9783841616500
- BindingPaperback
- Number of pages68
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Book Description Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The natural products from plants still remain an important source of pharmaceuticals. In the current study, bark and wood extracts of Ficus elastica aerial roots were screened for anti-cancer activity. Three new compounds, ficusamide, ficusoside and elasticoside, were isolated from the bark of aerial roots, together with nine known compounds. Three new compounds, elasticamide, elastiquinone and ficusoside B, together with four known compounds, were isolated from the wood of aerial roots. The structures of the new compounds were established by means of extensive spectroscopic analyses and by data with those reported for structurally related molecules. The isolated compounds were afterwards evaluated for their anti-proliferative effect on six human cancer cell lines using colorimetric MTT assay. Most notably, elastiquinone showed cytotoxic activity with IC50 = 14 µM against B16F10 melanoma cells, whereas the peracetylated form of ficusoside B displayed the lowest IC50 value (11 µM) against U373n glioma cell lines. The results of this investigation demonstrate that F. elastica might be a potential source for identifying new compounds with potent anti-proliferative activity. 68 pp. Englisch. Seller Inventory # 9783841616500
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Book Description Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The natural products from plants still remain an important source of pharmaceuticals. In the current study, bark and wood extracts of Ficus elastica aerial roots were screened for anti-cancer activity. Three new compounds, ficusamide, ficusoside and elasticoside, were isolated from the bark of aerial roots, together with nine known compounds. Three new compounds, elasticamide, elastiquinone and ficusoside B, together with four known compounds, were isolated from the wood of aerial roots. The structures of the new compounds were established by means of extensive spectroscopic analyses and by data with those reported for structurally related molecules. The isolated compounds were afterwards evaluated for their anti-proliferative effect on six human cancer cell lines using colorimetric MTT assay. Most notably, elastiquinone showed cytotoxic activity with IC50 = 14 µM against B16F10 melanoma cells, whereas the peracetylated form of ficusoside B displayed the lowest IC50 value (11 µM) against U373n glioma cell lines. The results of this investigation demonstrate that F. elastica might be a potential source for identifying new compounds with potent anti-proliferative activity. Seller Inventory # 9783841616500
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Book Description Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Mbosso Teinkela Jean EmmanuelLecturer-researcher, Emmanuel MBOSSO holds a Doctorate/Ph.D in Org. Chem. obtained under joint supervision between Univ. of Yaounde I (Cameroon) and the Univ. of Strasbourg (France). After his visit to th. Seller Inventory # 151613613
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