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Book Description Condition: New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book. Seller Inventory # ria9783838107035_lsuk
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Book Description Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The pharmaceutical and chemical industry is interested to replace in vivo experiments as much as possible with alternative in vitro models which have improved capability to assess and predict the safety profile of their products. This is influenced by the 3R principles of reducing, refining and replacing animal experiments (Russell & Burch, 1959). A major target in the safety testing of new chemical products is the liver. This is not surprising as the liver is the major organ for xenobiotic metabolism. Several different in vitro systems for the culture primary hepatocytes are actually used for acute toxicity-, mechanism of action-, metabolism- or enzyme induction studies. Yet, there is no established and standardized culture method maintaining hepatocyte specific functionality for longer term experiments. The author Jens Hrach elucidates advantages and disadvantages of various culture methods and gives a comprehensive overview over the actual state of the art. He describes the molecular and mechanistic characterization of a stable long term culture for hepatocytes and the subsequent use for a proof of concept toxicogenomics study. 248 pp. Deutsch. Seller Inventory # 9783838107035
Book Description Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The pharmaceutical and chemical industry is interested to replace in vivo experiments as much as possible with alternative in vitro models which have improved capability to assess and predict the safety profile of their products. This is influenced by the 3R principles of reducing, refining and replacing animal experiments (Russell & Burch, 1959). A major target in the safety testing of new chemical products is the liver. This is not surprising as the liver is the major organ for xenobiotic metabolism. Several different in vitro systems for the culture primary hepatocytes are actually used for acute toxicity-, mechanism of action-, metabolism- or enzyme induction studies. Yet, there is no established and standardized culture method maintaining hepatocyte specific functionality for longer term experiments. The author Jens Hrach elucidates advantages and disadvantages of various culture methods and gives a comprehensive overview over the actual state of the art. He describes the molecular and mechanistic characterization of a stable long term culture for hepatocytes and the subsequent use for a proof of concept toxicogenomics study. Seller Inventory # 9783838107035
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Book Description Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. The pharmaceutical and chemical industry is interested to replace in vivo experiments as much as possible with alternative in vitro models which have improved capability to assess and predict the safety profile of their products. This is influenced by the 3. Seller Inventory # 5405090