NEPHROTOXICITY: Major side effect of anti-cancer drug: Drug-associated renal dysfunction - Softcover

Joshi, Dhairya Y.; Taranalli, A.D.; P. Rana, Priyanka

Softcover

ISBN 10: 3659384321 ISBN 13: 9783659384325

Publisher: LAP LAMBERT Academic Publishing, 2013

Synopsis

Cisplatin (CDDP) is a major antineoplastic drug for the treatment of solid tumors such as metastatic bladder, testicular, and ovarian carcinomas. The drug can cause much toxicity, but the chief dose-limiting one is nephrotoxicity. Several, often interrelated mechanisms of actions have been hypothesized to induce the nephrotoxicity. These include apoptosis and inflammatory mechanism, production of tumor necrosis factor (TNF)-α by renal parenchymal cells, and generation of reactive oxygen species (ROS) that include superoxide dismutase, hydrogen radical, hydrogen peroxide, singlet oxygen, and nitric oxide. These techniques have proved to be only partially successful as acute renal failure occurs even at such low doses and especially after its repeated administration. The nephrotoxicity of cisplatin has been recognized since its introduction over 25 years ago. Early clinical use of cisplatin saw dose-related cisplatin-induced acute renal failure in 14 to 100% of patients, with the incidence varying with the cumulative dose. Clinical data have shown that approximately one third of patients experience kidney injury in days after cisplatin treatment, with reduced glomerular filtration.

About this title

About the Author:

Dhairya Y. joshi (M.pharm) is a PG student at KLE UNIVERSITY’S COLLEGE OF PHARMACY, BELGAUM, KARNATAKA. Dr. A D Taranalli is a principal at KLE UNIVERSITY’S COLLEGE OF PHARMACY, BELGAUM, KARNATAKA. Priyanka P. Rana (M.pharm) KLE UNIVERSITY’S COLLEGE OF PHARMACY, BELGAUM, KARNATAKA.

About this edition

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2013
• ISBN 10: 3659384321
• ISBN 13: 9783659384325
• Binding: Paperback
• Number of pages: 64