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The Origins of Depression: Current Concepts and Approaches: Report of the Dahlem Workshop on The Origins of Depression: Current Concepts and ... – Nov. 5: 26 (Dahlem Workshop Report, 26) - Softcover

 
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3 and a fraction mayor may not respond to treatment. On the behavioral level, animal research shows that a variety of experimental conditions can induce de­ pression. The same is true in the field of treatment, where pharmacologically highly different drugs can equally alleviate depression in animals and hu­ mans. The question as to whether this is due to a heterogeneity of depressive subjects based on different pathogenetic mechanisms is open to discussion. We can look for common features of all possible causal factors in the hope of finding a single basic mechanism. Many divergent findings may also be ex­ plained as peripheral changes of a highly complicated dynamic system. In the field of psychopharmacology, a circular reasoning has become evident in the sense that originally the clinical antidepressive response was founded on empirical grounds only. In a second step, an attempt was made to characterize some clinically active compounds pharmacologically, and in a third, further compounds were developed based on aspects of the pharmaco­ logical profiles. Moreover, the post hoc development of a pharmacological screening method has the serious disadvantage of delaying breakthroughs into new fields.

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9783540124511: The Origins of Depression: Current Concepts and Approaches: Report of the Dahlem Workshop on The Origins of Depression: Current Concepts and ... Oct.31 – Nov. 5: 26 (Dahlem Workshop Report)

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Carlsson, A.|Carroll, B. J.|Helmchen, H.|Herz, A.|Klerman, G. I.|McKinney, W. T.|Angst, J.|Angst, J.|Checkley, S. A.|Katschnig, H.|Potter, W. Z.|Reite, M. L.|Rush, A. J.
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