Items related to Molecular Mimicry: Infection Inducing Autoimmune Disease:...
Molecular Mimicry: Infection Inducing Autoimmune Disease: 296 (Current Topics in Microbiology and Immunology, 296) - Hardcover
The conceptual basis for molecular mimicry was first defined in the early 1980s when monoclonal antibodies against viruses were also shown to react with non-viral host protein; in this case, measles virus phosphoprotein cross-reacted with host cell cytokeratin, herpes simplex virus type 1 with host-cell vimentin and vaccinia virus with host-cell intermediate filaments. Following this discovery, others emerged, again at the clonal level, that T cell clones against proteins from a variety of infectious agents also reacted with host antigenic determinants. The clonal distinction was imperative for the initial definition of mimicry. At least 30 years prior to our initial description of molecular mimicry involving cross-reactions between numerous microbes, on the polyclonal antibody level, streptococcus was believed to react with renal glomeruli, heart and basal ganglia to account for the glomerulonephritis, heart and valvular disease and chorea, respectively. However, subsequent research showed that the nephritis was caused by immune complex deposits and the tissue damage they produced. Later, in 1990, the cross-reactivity of streptococcal antigen with myocardial antigens on a clonal level was uncovered. Hence, for both historical reasons and mechanistic understanding, it is best to provide evidence for cross-reactivity at the clonal level to prove that molecular mimicry exists.
"synopsis" may belong to another edition of this title.
From the Back Cover:
(Text will follow)
"About this title" may belong to another edition of this title.
- PublisherSpringer
- Publication date2005
- ISBN 10 3540255974
- ISBN 13 9783540255970
- BindingHardcover
- Number of pages175
- EditorOldstone Michael B. A.
Buy New
Learn more about this copy
£ 111.27
Shipping:
FREE
Within U.S.A.
Top Search Results from the AbeBooks Marketplace
Stock Image
Molecular Mimicry: Infection Inducing Autoimmune Disease
Seller:
Rating
Book Description Condition: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service. Seller Inventory # ABEOCT23-367404
Buy New
£ 111.27
Convert currency
Stock Image
MOLECULAR MIMICRY: INFECTION IND
Seller:
Rating
Book Description Condition: New. New. In shrink wrap. Looks like an interesting title! 0.8. Seller Inventory # Q-3540255974
Buy New
£ 192.11
Convert currency
Stock Image
Molecular Mimicry: Infection Inducing Autoimmune Disease
Published by
Springer
(2005)
ISBN 10: 3540255974
ISBN 13: 9783540255970
New
Hardcover
Quantity: > 20
Seller:
Rating
Book Description Condition: New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book. Seller Inventory # ria9783540255970_lsuk
Buy New
£ 208.92
Convert currency
Seller Image
Molecular Mimicry: Infection Inducing Autoimmune Disease (Current Topics in Microbiology and Immunology) [Hardcover ]
Seller:
Rating
Book Description Hardcover. Condition: new. Seller Inventory # 9783540255970
Buy New
£ 220.50
Convert currency
Stock Image
Molecular Mimicry
Seller:
Rating
Book Description Condition: New. pp. 166 Index 1st Edition. Seller Inventory # 262178525
Buy New
£ 226.58
Convert currency
Seller Image
Molecular Mimicry: Infection Inducing Autoimmune Disease
Published by
Springer Berlin Heidelberg
(2005)
ISBN 10: 3540255974
ISBN 13: 9783540255970
New
Hardcover
Quantity: > 20
Seller:
Rating
Book Description Gebunden. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Molecular Mimicry, Microbial Infection and Autoimmune Disease: Evolution of the Concept.- A Virus-Induced Molecular Mimicry Model of Multiple Sclerosis.- Suppression of Autoimmunity via Microbial Mimics of Altered Peptide Ligands.- Molecular and Cellular Me. Seller Inventory # 4886556
Buy New
£ 197.69
Convert currency
Stock Image
Molecular Mimicry: Infection Inducing Autoimmune Disease (Current Topics in Microbiology and Immunology, 296)
Published by
Springer
(2005)
ISBN 10: 3540255974
ISBN 13: 9783540255970
New
Hardcover
Quantity: > 20
Seller:
Rating
Book Description Condition: New. Seller Inventory # ABLIING23Mar3113020164233
Buy New
£ 240.88
Convert currency
Seller Image
Molecular Mimicry: Infection Inducing Autoimmune Disease
Published by
Springer Berlin Heidelberg Nov 2005
(2005)
ISBN 10: 3540255974
ISBN 13: 9783540255970
New
Hardcover
Quantity: 2
Seller:
Rating
Book Description Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The purpose of this review is to examine the potential role of molecular mimicry in the pathogenesis of human T-lymphotropic virus type 1 ((HTLV- 1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP)). Comp- hensive reviews on the pathogenic mechanisms of HTLV-1-associated human diseases are available throughout the medical literature (Bangham 2000, 2003; Barmak et al. 2003; Jacobson 2002; Levin and Jacobson 1997; Nagai and Osame 2003; Osame 2002). Approximately 25 years ago the rst human retrovirus, HTLV-1, was isolated (Poeisz et al. 1980). Subsequently, infection with HTLV-1 was shown to cause adult T-cell leukemia (ATL) and HAM/TSP (Gessain et al. 1985; McFarlin and Blattner 1991; Osame et al. 1986; Poeisz et al. 1980; Yoshida et al. 1987). HTLV-1 may infect up to 30% of people in endemic areas and 10 20 million people worldwide (Barmak et al. 2003; Edlich et al. 2000). However, only 1% 5% develop either ATL or HAM/TSP, the remainder being clinically asymptomatic carriers of HTLV-1 (Bangham 2000, 2003; Barmak et al. 2003; Jacobson 2002; Levin and Jacobson 1997; Nagai and Osame 2003; Osame 2002). Why infection with HTLV-1 causes ATL or HAM/TSP in some people while the vast majority of individuals are asymptomatic is largely - known. Some possible factors that may differentiate the asymptomatic from the diseased state include viral strain, human histocompatibility leukocyte antigen (HLA), viral load, and the immune response (Bangham 2000, 2003; Barmak et al. 2003; Jacobson 2002; Levin and Jacobson 1997; Nagai and Osame 2003; Nagai et al. 1998; Niewiesk et al. 1994; Osame 2002). 180 pp. Englisch. Seller Inventory # 9783540255970
Buy New
£ 236.10
Convert currency
Stock Image
Molecular Mimicry
Seller:
Rating
Book Description Condition: New. pp. 166 Illus. Seller Inventory # 5669378
Buy New
£ 255.73
Convert currency
Seller Image
Molecular Mimicry: Infection Inducing Autoimmune Disease
Published by
Springer Berlin Heidelberg
(2005)
ISBN 10: 3540255974
ISBN 13: 9783540255970
New
Hardcover
Quantity: 1
Seller:
Rating
Book Description Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - The purpose of this review is to examine the potential role of molecular mimicry in the pathogenesis of human T-lymphotropic virus type 1 ((HTLV- 1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP)). Comp- hensive reviews on the pathogenic mechanisms of HTLV-1-associated human diseases are available throughout the medical literature (Bangham 2000, 2003; Barmak et al. 2003; Jacobson 2002; Levin and Jacobson 1997; Nagai and Osame 2003; Osame 2002). Approximately 25 years ago the rst human retrovirus, HTLV-1, was isolated (Poeisz et al. 1980). Subsequently, infection with HTLV-1 was shown to cause adult T-cell leukemia (ATL) and HAM/TSP (Gessain et al. 1985; McFarlin and Blattner 1991; Osame et al. 1986; Poeisz et al. 1980; Yoshida et al. 1987). HTLV-1 may infect up to 30% of people in endemic areas and 10 20 million people worldwide (Barmak et al. 2003; Edlich et al. 2000). However, only 1% 5% develop either ATL or HAM/TSP, the remainder being clinically asymptomatic carriers of HTLV-1 (Bangham 2000, 2003; Barmak et al. 2003; Jacobson 2002; Levin and Jacobson 1997; Nagai and Osame 2003; Osame 2002). Why infection with HTLV-1 causes ATL or HAM/TSP in some people while the vast majority of individuals are asymptomatic is largely - known. Some possible factors that may differentiate the asymptomatic from the diseased state include viral strain, human histocompatibility leukocyte antigen (HLA), viral load, and the immune response (Bangham 2000, 2003; Barmak et al. 2003; Jacobson 2002; Levin and Jacobson 1997; Nagai and Osame 2003; Nagai et al. 1998; Niewiesk et al. 1994; Osame 2002). Seller Inventory # 9783540255970
Buy New
£ 238.94
Convert currency