Items related to High-Resolution Profiling of Protein-RNA Interactions...
The work reported in this book represents an excellent example of how creative experimentation and technology development, complemented by computational data analysis, can yield important insights that further our understanding of biological entities from a systems perspective. The book describes how the study of a single RNA-binding protein and its interaction sites led to the development of the novel 'protein occupancy profiling' technology that for the first time captured the mRNA sequence space contacted by the ensemble of expressed RNA binders. Application of protein occupancy profiling to eukaryotic cells revealed that extensive sequence stretches in 3' UTRs can be contacted by RBPs and that evolutionary conservation as well as negative selection act on protein-RNA contact sites, suggesting functional importance. Comparative analysis of the RBP-bound sequence space has the potential to unravel putative cis-acting RNA elements without a priori knowledge of the bound regulators. Here, Dr. Munschauer provides a comprehensive introduction to the field of post-transcriptional gene regulation, examines state-of-the-art technologies, and combines the conclusions from several journal articles into a coherent and logical story from the frontiers of systems-biology inspired life science. This thesis, submitted to the Department of Biology, Chemistry and Pharmacy at Freie Universitat Berlin, was selected as outstanding work by the Berlin Institute for Medical Systems Biology at the Max-Delbrueck Center for Molecular Medicine, Germany.
"synopsis" may belong to another edition of this title.
- PublisherSpringer
- Publication date2015
- ISBN 10 3319162527
- ISBN 13 9783319162522
- BindingHardcover
- Number of pages144
Top Search Results from the AbeBooks Marketplace
Seller Image
High-Resolution Profiling of Protein-RNA Interactions (Springer Theses) [Hardcover ]
Seller:
Rating
Book Description Hardcover. Condition: new. Seller Inventory # 9783319162522
Buy New
£ 87.61
Convert currency
Stock Image
High-Resolution Profiling of Protein-RNA Interactions (Springer Theses)
Published by
Springer
(2015)
ISBN 10: 3319162527
ISBN 13: 9783319162522
New
Hardcover
Quantity: > 20
Seller:
Rating
Book Description Condition: New. Seller Inventory # ABLIING23Mar3113020089843
Buy New
£ 95.80
Convert currency
Stock Image
High-Resolution Profiling of Protein-RNA Interactions
Published by
Springer
(2015)
ISBN 10: 3319162527
ISBN 13: 9783319162522
New
Hardcover
Quantity: > 20
Seller:
Rating
Book Description Condition: New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book. Seller Inventory # ria9783319162522_lsuk
Buy New
£ 96.28
Convert currency
Seller Image
High-Resolution Profiling of Protein-RNA Interactions
Published by
Springer International Publishing Mrz 2015
(2015)
ISBN 10: 3319162527
ISBN 13: 9783319162522
New
Buch
Quantity: 2
Seller:
Rating
Book Description Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The work reported in this book represents an excellent example of how creative experimentation and technology development, complemented by computational data analysis, can yield important insights that further our understanding of biological entities from a systems perspective. The book describes how the study of a single RNA-binding protein and its interaction sites led to the development of the novel 'protein occupancy profiling' technology that for the first time captured the mRNA sequence space contacted by the ensemble of expressed RNA binders. Application of protein occupancy profiling to eukaryotic cells revealed that extensive sequence stretches in 3' UTRs can be contacted by RBPs and that evolutionary conservation as well as negative selection act on protein-RNA contact sites, suggesting functional importance. Comparative analysis of the RBP-bound sequence space has the potential to unravel putative cis-acting RNA elements without a priori knowledge of the bound regulators. Here, Dr. Munschauer provides a comprehensive introduction to the field of post-transcriptional gene regulation, examines state-of-the-art technologies, and combines the conclusions from several journal articles into a coherent and logical story from the frontiers of systems-biology inspired life science. This thesis, submitted to the Department of Biology, Chemistry and Pharmacy at Freie Universität Berlin, was selected as outstanding work by the Berlin Institute for Medical Systems Biology at the Max-Delbrueck Center for Molecular Medicine, Germany. 148 pp. Englisch. Seller Inventory # 9783319162522
Buy New
£ 94.38
Convert currency
Seller Image
High-Resolution Profiling of Protein-RNA Interactions
Published by
Springer International Publishing
(2015)
ISBN 10: 3319162527
ISBN 13: 9783319162522
New
Hardcover
Quantity: > 20
Seller:
Rating
Book Description Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Nominated as outstanding PhD thesis by Max-Delbrueck Center for Molecular Medicine, GermanyDescribes the development of a novel technology for transcriptome-wide analysis of protein-RNA interactionsPaves the way to future genome-wide studies. Seller Inventory # 21922112
Buy New
£ 81.39
Convert currency
Seller Image
High-Resolution Profiling of Protein-RNA Interactions
Published by
Springer International Publishing
(2015)
ISBN 10: 3319162527
ISBN 13: 9783319162522
New
Hardcover
Quantity: 1
Seller:
Rating
Book Description Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - The work reported in this book represents an excellent example of how creative experimentation and technology development, complemented by computational data analysis, can yield important insights that further our understanding of biological entities from a systems perspective. The book describes how the study of a single RNA-binding protein and its interaction sites led to the development of the novel 'protein occupancy profiling' technology that for the first time captured the mRNA sequence space contacted by the ensemble of expressed RNA binders. Application of protein occupancy profiling to eukaryotic cells revealed that extensive sequence stretches in 3' UTRs can be contacted by RBPs and that evolutionary conservation as well as negative selection act on protein-RNA contact sites, suggesting functional importance. Comparative analysis of the RBP-bound sequence space has the potential to unravel putative cis-acting RNA elements without a priori knowledge of the bound regulators. Here, Dr. Munschauer provides a comprehensive introduction to the field of post-transcriptional gene regulation, examines state-of-the-art technologies, and combines the conclusions from several journal articles into a coherent and logical story from the frontiers of systems-biology inspired life science. This thesis, submitted to the Department of Biology, Chemistry and Pharmacy at Freie Universität Berlin, was selected as outstanding work by the Berlin Institute for Medical Systems Biology at the Max-Delbrueck Center for Molecular Medicine, Germany. Seller Inventory # 9783319162522
Buy New
£ 96.52
Convert currency