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Epithelial Polarity (Colloquium Series on Building Blocks of the Cell: Cell Structure and Function) - Softcover
Synopsis
Epithelial cells exhibit an apical–basolateral axis of polarity that is generated during embryogenesis, is maintained throughout adult life in the face of constant cell regeneration, and is perturbed in several epithelial-associated diseases. We examine the structural and functional organization of epithelial tissues, as well as the events critical for generating epithelial asymmetry including vectorial trafficking of proteins and lipids, association of signaling and polarity proteins with subdomains of the plasma membrane, and 3D orientation of epithelial cells in response to cell–cell and cell–matrix interactions. As a paradigm to understand how these three processes are coordinated in time and space, we explore apical lumen formation. We also examine the final steps in epithelial morphogenesis, including brush border morphogenesis and ciliogenesis. Finally, we provide examples of disease processes that result from defects in epithelial polarity including diabetes insipidus, microvillar inclusion disease, hereditary deafness, ciliopathies, and cancer. Table of Contents: Introduction / Epithelial Cell Organization and Asymmetry / Generation and Maintenance of Epithelial Polarity / Diseases that Result from Defects in Epithelial Polarity / Acknowledgments / References / Author Biographies
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- PublisherMorgan & Claypool Life Sciences
- Publication date2013
- ISBN 10 1615043985
- ISBN 13 9781615043989
- BindingPaperback
- Number of pages122
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Epithelial Polarity (Colloquium Building Blocks of the Cell: Cell Structure and Function)
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Morgan & Claypool Life Sciences, 2013
ISBN 10: 1615043985
ISBN 13: 9781615043989
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Epithelial Polarity
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Epithelial Polarity
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ISBN 13: 9781615043989
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Epithelial Polarity
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Epithelial cells exhibit an apical-basolateral axis of polarity that is generated during embryogenesis, is maintained throughout adult life in the face of constant cell regeneration, and is perturbed in several epithelial-associated diseases. We examine the structural and functional organization of epithelial tissues, as well as the events critical for generating epithelial asymmetry including vectorial trafficking of proteins and lipids, association of signaling and polarity proteins with subdomains of the plasma membrane, and 3D orientation of epithelial cells in response to cell-cell and cell-matrix interactions. As a paradigm to understand how these three processes are coordinated in time and space, we explore apical lumen formation. We also examine the final steps in epithelial morphogenesis, including brush border morphogenesis and ciliogenesis. Finally, we provide examples of disease processes that result from defects in epithelial polarity including diabetes insipidus, microvillar inclusion disease, hereditary deafness, ciliopathies, and cancer. Seller Inventory # 9781615043989
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Epithelial cells exhibit an apical-basolateral axis of polarity that is generated during embryogenesis, is maintained throughout adult life in the face of constant cell regeneration, and is perturbed in several epithelial-associated diseases. Ths book exami. Seller Inventory # 448166671
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