Chromatin and Disease: 41 (Subcellular Biochemistry, 41) - Hardcover

Hardcover

ISBN 10: 1402054653 ISBN 13: 9781402054655

Publisher: Springer, 2007

Synopsis

This book includes a collection of articles with the broad theme of disease connection to chromatin structure and function. It elaborates on the molecular pharmacology of the drugs targeting chromatin structure and its components. The book contains up-to-date information about the chromatin structure and chromatin related diseases and drug functions. This work is the first endeavor to present different aspects encompassing the above theme.

About this title

Synopsis:

The packaging of genomic DNA together with core histones, linker histones, and other functional proteins into chromatin play key roles in nuclear processes such as transcription, replication, repair and recombination. Research in the last two decades has unveiled the fact that many diseases involve an aberration of these processes at the chromatin level. Similarly, it is becoming clear that different processes such as chromatin assembly, remodeling of chromatin structure coupled to covalent modification of histone and non-histone proteins, chromatin modifying enzymes and last but not the least, important DNA-templated phenomena are the potential drug targets for diseases such as different types of cancer, neurodegenrative diseases, AIDS etc. While, the earliest form of chemotherapy employed chromosomal DNA cleavage and modification, the study of epigenetic functions and therapy has recently emerged as a frontline research activity. At this juncture we felt the necessity to make an overview of the current research activities in the above areas. It is obvious that this collection starts with our current knowledge of chromatin structure.

This work is the first endeavor to present different aspects encompassing the above theme.

About this edition

• Publisher: Springer
• Publication date: 2007
• ISBN 10: 1402054653
• ISBN 13: 9781402054655
• Binding: Hardcover
• Number of pages: 472
• Editor: Kundu Tapas K., Dasgupta Dipak